Human Embryonic Stem Cells in Treatment of Spinal Cord Injury: A Prospective Study

Shroff, Geeta; Agarwal, Puneet; Mishra, Avinash; Sonowal, Nayan

doi:10.14740/jnr339w

Cited by 3 publications

(4 citation statements)

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“…The treatment modalities of these diseases [3]. Embryonal stem cells (ESCs) are the best source of omnipotent stem cells as they have an unlimited potential to produce any specialised cell type of an organism [3,16].…”

Section: Resultsmentioning

confidence: 99%

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Acquisition and Expansion of Adult Rat Bone Marrow Multipotent Mesenchymal Stromal Cells

2017

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Section: Resultsmentioning

confidence: 99%

“…Experimental results suggest the almost unrestricted capacity for their utilisation in replacement therapy and regenerative medicine [16,17]. On the other hand, the fact that a blastocyst developing from a fertilized egg has to be is recommended [7].…”

Section: Resultsmentioning

confidence: 99%

Acquisition and Expansion of Adult Rat Bone Marrow Multipotent Mesenchymal Stromal Cells

2017

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“…33 In our previous study, we have observed remarkable clinical improvements in 11 SCI patients with hESC therapy. 34…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging tractography as a diagnostic tool in patients with spinal cord injury treated with human embryonic stem cells

Shroff¹

2017

Neuroradiol J

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Introduction Spinal cord injury is a cause of severe disability and mortality. The pharmacological and non-pharmacological methods used, are unable to improve the quality of life in spinal cord injury. Spinal disorders have been treated with human embryonic stem cells. Magnetic resonance imaging and tractography were used as imaging modality to document the changes in the damaged cord, but the magnetic resonance imaging tractography was seen to be more sensitive in detecting the changes in the spinal cord. The present study was conducted to evaluate the diagnostic modality of magnetic resonance imaging tractography to determine the efficacy of human embryonic stem cells in chronic spinal cord injury. Materials and methods The study included the patients with spinal cord injury for whom magnetic resonance imaging tractography was performed before and after the therapy. Omniscan (gadodiamide) magnetic resonance imaging tractography was analyzed to assess the spinal defects and the improvement by human embryonic stem cell treatment. The patients were also scored by American Spinal Injury Association scale. Results Overall, 15 patients aged 15-44 years with clinical manifestations of spinal cord injury had magnetic resonance imaging tractography performed. The average treatment period was nine months. The majority of subjects ( n = 13) had American Spinal Injury Association score A, and two patients were at score C at the beginning of therapy. At the end of therapy, 10 patients were at score A, two patients were at score B and three patients were at score C. Improvements in patients were clearly understood through magnetic resonance imaging tractography as well as in clinical signs and symptoms. Conclusion Magnetic resonance imaging tractography can be a crucial diagnostic modality to assess the improvement in spinal cord injury patients.

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“…[17][18][19][20][21] We recently reported a remarkable clinical improvement in 11 patients with SCI treated with hESC therapy in a prospective study. 22 We have also reported the safety and efficacy of hESC therapy in patients with cerebral palsy, cortico-visual impairment, Friedrich ataxia, Lyme disease, spinocerebellar ataxia, and Duchenne muscular dystrophy. [23][24][25][26][27][28] In this paper, we present the retrospective evaluation of our patients with SCI treated with hESC therapy.…”

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Human Embryonic Stem Cell Therapy in Chronic Spinal Cord Injury: A Retrospective Study

Shroff¹

2016

Clinical Translational Sci

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Human embryonic stem cells (hESCs) have a role in treating neurological disorders. The efficacy and safety of hESC in treating spinal cord injury (SCI) was reported in our previous study. In the present study, we have evaluated the efficacy and safety of hESC therapy in 226 patients with SCI. In the first treatment phase (T1), 0.25 mL hESCs were administered intramuscularly twice daily, 1 mL every 10 days i.v., and 1–5 mL every 7 days. Of 153 patients in the American Spinal Injury Association (ASIA) scale A at the beginning of T1, a significant number of patients (n = 80; 52.3%) moved to lower scales at the end of T1 (p = 0.01). At the end of T2, of 32 patients in ASIA scale A, 12 patients (37.5%) moved to scale B (p = 0.01). Of 19 patients, 3 patients (37.5%) moved to scale B at the end of T3 (p = 0.02). No serious adverse events (AEs) were observed. hESC transplantation is safe and effective.

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Human Embryonic Stem Cells in Treatment of Spinal Cord Injury: A Prospective Study

Cited by 3 publications

References 25 publications

Acquisition and Expansion of Adult Rat Bone Marrow Multipotent Mesenchymal Stromal Cells

Acquisition and Expansion of Adult Rat Bone Marrow Multipotent Mesenchymal Stromal Cells

Magnetic resonance imaging tractography as a diagnostic tool in patients with spinal cord injury treated with human embryonic stem cells

Human Embryonic Stem Cell Therapy in Chronic Spinal Cord Injury: A Retrospective Study

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