Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1

Matsuoka, Rumiko; Sawamura, Tatsuya; Yamada, Kaori; Yoshida, Michihiro; Furutani, Yasuji; Ikura, Tsuyoshi; Shiraki, Takuma; Hoshikawa, Hiroaki; Shimada, Kota; Tanzawa, Kazuhiko; Masaki, Τοmoh

doi:10.1159/000134214

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…According to a recent review, current research has determined that endothelin plays a major role in the growth and progression of malignant tumors and its receptors are considered pivotal in the progression of breast cancer and the invasion of breast cancer tumor cells . The two genes are located in the same area in the 1p36 locus . In our study there was no association between the Rh factor and breast cancer risk.…”

Section: Discussioncontrasting

confidence: 43%

Influence of ABO blood group and Rhesus factor on breast cancer risk: A meta‐analysis of 9665 breast cancer patients and 244 768 controls

Miao

Zhou

Chen

et al. 2013

Asia-Pac J Clncl Oncology

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Aim: Blood group is an important risk factor for some malignancies, including pancreatic and stomach cancer. However, it is unclear whether the risk of breast cancer is higher in any specific ABO blood type. Methods: We searched the electronic database of PubMed, EMBASE, China National Knowledge Infrastructure and the VIP Chinese Journal of Science and Technology for case-control studies about blood type and breast cancer incidence, and a meta-analysis was conducted. Results: Fourteen studies were eligible for assessment on the association of breast cancer with different blood types, including 9665 breast cancer patients and 244 768 controls. Relative to blood type O, women with blood type A (odds ratio (OR) = 1.115, 95% confidence interval (CI) 0.992-1.254), B (OR = 0.983, 95% CI 0.915-1.056) and AB (OR = 1.042, 95% CI 0.881-1.231) had the same breast cancer risk. The risk for women with Rhesus-positive (Rh+) was the same as those with Rh-negative (Rh-) (OR = 0.948, 95% CI 0.667-1.348). Among Caucasians, the OR of blood type A was 1.066 (95% CI, 1.001-1.134, P = 0.522 for heterogeneity). Conclusion:This meta-analysis suggests Caucasians with blood type A may have a higher risk of breast cancer than other Caucasians. No association was found in any other blood type or any other population. Similarly, the Rh factor had no association with the risk of breast cancer.

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Section: Discussioncontrasting

confidence: 43%

Influence of ABO blood group and Rhesus factor on breast cancer risk: A meta‐analysis of 9665 breast cancer patients and 244 768 controls

Miao

Zhou

Chen

et al. 2013

Asia-Pac J Clncl Oncology

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“…Subsequently, a study of the structure of the human ECE-1 gene (34) indicated that ECE-la and ECE-113 (referred to as ECE-ib and -la in that paper, respectively) are encoded by the same gene. The gene is composed of 19 exons that span more than 68 kb and has been mapped to the lp36 band of the human genome (35,36). The precursor m-RNAs of ECE-la and -1f are transcribed from two distinct start sites, upstream of exon 1 and exon 3, respectively.…”

Section: Gene Structure Of Ece-1 and Possible Transcriptional Regulationmentioning

confidence: 99%

Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX

Turner

Tanzawa²

1997

FASEB j.

388

233

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Mammalian cell-surface peptidases participate in the postsecretory processing and metabolism of neuropeptides and peptide hormones. Neutral endopeptidase-24.11 (NEP) is the prototype of a family of zinc metallopeptidases that also includes the endothelin-converting enzymes (ECE) and which are structurally related to the bacterial enzymes thermolysin and lactococcal endopeptidase. Two other mammalian gene products exhibit strong homology with NEP: the erythrocyte cell-surface antigen, KELL; and the putative product of the PEX gene, which has been associated with X-linked hypophosphatemic rickets. No enzymic activity has yet been attributed to KELL and PEX proteins, and they remain peptidases in search of a substrate. A wide range of biologically active peptide substrates has been described for NEP, of which the enkephalins and the atrial natriuretic peptide family have assumed greatest significance. Endothelin-converting enzyme catalyses the final step in the biosynthesis of the vasoconstrictor peptide, endothelin (ET). Like NEP, it is a type II integral membrane protein, but is expressed predominantly in endothelial cells. Isoforms of ECE (ECE-1alpha, ECE-1beta, and ECE-2) exist that differ in a number of characteristics. In particular, ECE-1, through the paracrine effects of ET-1, may contribute to the proliferation of smooth muscle after angioplasty and to the development of human atherosclerosis. Inhibitors of ECE and NEP may have important therapeutic applications in cardiovascular and renal medicine.

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