Human epidermal growth factor: renal production and absence from plasma

Mattila, Anna-Liisa; Viinikka, Lasse; Saario, I.; Perheentupa, Jaakko

doi:10.1016/0167-0115(88)90424-7

Cited by 44 publications

(23 citation statements)

References 15 publications

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“…In mice EGF is a circulating compound (3) although blood EGF in humans is associated in platelets (14,15). Our present results may explain some previous conflict¬ ing findings on sex difference.…”

Section: Discussioncontrasting

confidence: 66%

Epidermal growth factor in mice: changes during circadian and female reproductive cycles

Tuomela

Viinikka²,

Perheentupa³

1990

Acta Endocrinologica

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To clarify the variation of mouse epidermal growth factor production during the 24-h and female reproductive cycles, we measured its concentrations in the plasma, submandibular salivary gland, urine, kidneys and liver of adult male and female mice during consecutive 12-h dark and 12-h light periods, different stages of pregnancy, and lactation. The concentration of epidermal growth factor in the submandibular gland showed no circadian changes. In plasma and in the liver it increased during the dark period, whereas in urine and in the kidneys it peaked in the daytime. In the submandibular gland the concentration decreased during early pregnancy, but it returned to the non-pregnant levels by midpregnancy. In plasma it decreased progressively during pregnancy and recovered during lactation. In urine and the kidneys the concentration of epidermal growth factor increased after early pregnancy; with a further great increase in the kidneys during lactation. In the liver the concentration was clearly below the non-pregnant levels during late pregnancy and lactation.

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Section: Discussioncontrasting

confidence: 66%

Epidermal growth factor in mice: changes during circadian and female reproductive cycles

Tuomela

Viinikka²,

Perheentupa³

1990

Acta Endocrinologica

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“…Both THP and EGF are synthesized in the distal part of the nephron [1, 22, 23, 24], and this synthesis accounts for the urinary excretion of the two peptides [1, 4, 6]. The urinary excretions of THP and EGF have been shown to correlate with the creatinine clearance in patients with renal diseases [8, 9, 10, 11, 13, 15, 16] and it has, therefore, been suggested that the excretions of THP and EGF correlate with the GFR.…”

Section: Discussionmentioning

confidence: 99%

“…The glomerular filtration of these peptides from plasma is negligible, so almost all THP and EGF in the urine is of renal origin [1, 3, 4, 6]. The possible physiological roles of THP and EGF in the kidney and urinary tract have not been established yet.…”

Section: Introductionmentioning

confidence: 99%

Urinary Excretion of Tamm-Horsfall Protein and Epidermal Growth Factor in Chronic Nephropathy

Torffvit

Jørgensen

Kamper

et al. 1998

Nephron

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Tamm-Horsfall protein (THP) and epidermal growth factor (EGF) are both synthesized by tubular cells in the distal part of the nephron and excreted with the urine. The present study examines the urinary excretion rates of the two peptides in relation to functional tubular markers in patients with chronic nephropathy. Four groups of patients with moderate to severely reduced renal function were studied: glomerulonephritis (n = 10), diabetic nephropathy (n = 11), tubulointerstitial nephropathy (n = 13), and polycystic kidney disease (n = 8). The renal function was evaluated by glomerular filtration rate (GFR) as an indicator for the general renal function, lithium clearance (C_Li) as an indicator for proximal tubular function, and absolute distal reabsorption of sodium (ADR_Na) as an indicator for distal tubular function. The excretion rate of EGF was rather closely correlated with GFR, C_Li and ADR_Na (Spearman coefficients of variation 0.88, 0.69, and 0.74, respectively). The correlations between the excretion rate of THP and GFR, C_Li and ADR_Na were weaker (Spearman coefficients of variation 0.68, 0.42, and 0.44). When the effect of GFR had been accounted for by multiple variance analyses, the excretion rates of the two peptides were still associated with ADR_Na but not with C_Li. In conclusion, the urinary excretion rates of especially EGF but also those of THP were correlated with renal function and distal tubular reabsorption of sodium in patients with chronic nephropathy.

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“…It is thus reasonable to consider kidney tissue mass as another, or even the most, important factor in urinary EGF excretion besides renal function [9]. The fact that the urinary EGF concentration falls by approximate- ly 50% after unilateral nephrectomy or kidney transplantation provides further support in this aspect [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Urinary Epidermal Growth Factor Excretion in Children with Chronic Renal Failure

Tsau¹,

Chen²

1999

Am J Nephrol

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To investigate the excretion of urinary epidermal growth factor (EGF) in children with chronic renal failure (CRF), we have measured the urinary EGF/creatinine ratio (EGF/Cr) and the 24-hour urine EGF concentration in 19 children with CRF, 11 children with kidney disease and normal creatinine clearance, and 12 healthy children. Children with CRF had a significantly lower daily urine EGF concentration as well as urinary EGF/Cr. In contrast, children with kidney disease and normal renal function had normal daily urine EGF levels and urinary EGF/Cr. Accompanied by no difference in serum EGF between these two groups of patients, these data provide indirect evidence of the kidney as a source of human urinary EGF. There was a positive correlation of urinary EGF/Cr with creatinine clearance in all renal patients (r = 0.608, n = 30, p < 0.001). A much better correlation was found between daily urine EGF and creatinine clearance (r = 0.855, n = 30, p < 0.001). Our results implicate that there is a functional relationship between glomerular filtration and urinary EGF excretion, and that the urinary EGF/Cr may be a reliable indicator of urinary EGF excretion in children with CRF.

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Human epidermal growth factor: renal production and absence from plasma

Cited by 44 publications

References 15 publications

Epidermal growth factor in mice: changes during circadian and female reproductive cycles

Epidermal growth factor in mice: changes during circadian and female reproductive cycles

Urinary Excretion of Tamm-Horsfall Protein and Epidermal Growth Factor in Chronic Nephropathy

Urinary Epidermal Growth Factor Excretion in Children with Chronic Renal Failure

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