2014
DOI: 10.1002/bies.201300166
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Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges

Abstract: Epithelial hair follicle stem cells (eHFSCs) are required to generate, maintain and renew the continuously cycling hair follicle (HF), supply cells that produce the keratinized hair shaft and aid in the reepithelialization of injured skin. Therefore, their study is biologically and clinically important, from alopecia to carcinogenesis and regenerative medicine. However, human eHFSCs remain ill defined compared to their murine counterparts, and it is unclear which murine eHFSC markers really apply to the human … Show more

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Cited by 124 publications
(175 citation statements)
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“…As outlined above, dogs and humans share some properties regarding their HC, the SC-associated biomarker expression pattern and hormonal responses. Purba et al (2014) have already summarized the major disadvantages of the murine model when studying human HF SCs. Our results may, in the future, also contribute to the understanding of human alopecia and skin cancer development, and our ongoing further investigations may help to find new therapeutic approaches for disorders associated with an impaired SC compartment.…”
Section: Discussionmentioning
confidence: 99%
“…As outlined above, dogs and humans share some properties regarding their HC, the SC-associated biomarker expression pattern and hormonal responses. Purba et al (2014) have already summarized the major disadvantages of the murine model when studying human HF SCs. Our results may, in the future, also contribute to the understanding of human alopecia and skin cancer development, and our ongoing further investigations may help to find new therapeutic approaches for disorders associated with an impaired SC compartment.…”
Section: Discussionmentioning
confidence: 99%
“…The HF's upper, distal part can be separated into four compartments. The bulge region of the outer root sheath (ORS), the seat of HF epithelial stem cells (Purba et al 2014), the isthmus and the junctional zone (the regions below or around the insertion of the sebaceous gland duct, respectively), and the infundibulum, which extends from the entrance of the sebaceous duct to the HF ostium, the opening of the HF onto the skin surface (Fig. 1).…”
mentioning
confidence: 99%
“…The reasons for the observed intriguing differences between the impact of the metabolically stable N 1 -MeSpd versus Spd on K15 and K19 expression are still unclear. Indeed, the functional significance of both markers for HF stem cell biology remains obscure, and these markers might demarcate different subsets of cells, with different functions in the HF epithelium [14]. It is hypothesized that K19?…”
Section: Discussionmentioning
confidence: 99%