Human Epstein-Barr Virus and Cancer

Õsato, Toyoro; Mizuno, Fumio; Fujiwara, Shigeyoshi; Koizumi, Shigeki

doi:10.1007/978-1-4612-5002-9_6

Cited by 4 publications

(1 citation statement)

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“…These minimum peptide Tables 4 and 5 and text). § ND, Not determined. (Zuckerman & Howard, 1979;Mahy, 1985;Osato et al, 1986), indicates the likelihood ofT cell involvement in the control of HPV infection. In particular, the Th cell regulatory compartment is critical for any effective immune response.…”

Section: Proliferation In Response To Truncated Peptides and Identifimentioning

confidence: 99%

Definition of murine T helper cell determinants in the major capsid protein of human papillomavirus type 16

Davies

Hill²,

Rothbard³

et al. 1990

Journal of General Virology

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Three murine major histocompatibility complex (MHC) class II-restricted T cell determinants were identified in the major capsid protein L1 of human papillomavirus (HPV) type 16. Peptides derived from HPV-16 L1, which contain putative T cell epitopes located by a predictive algorithm, were synthesized and tested for lymphoproliferative activity by direct immunization, followed by in vitro assay of responses to peptides or recombinant HPV-16 L1. The MHC restriction of the stimulatory peptides was determined using blocking monoclonal antibodies against class II molecules. The responses, which were specific for the priming peptides alone, cross-reacted with recombinant L1 but not with analogous peptides derived from other HPV types.

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Section: Proliferation In Response To Truncated Peptides and Identifimentioning

confidence: 99%