Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants

Charlier, Corinne; Desaive, C; Plomteux, Guy

doi:10.1038/sj.ijo.0802144

Cited by 33 publications

(22 citation statements)

References 22 publications

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“…If adipose tissue levels did decrease in our subjects, the associations found would underestimate the true relationship. In contrast, studies of organochlorine levels after sudden weight loss in obese individuals have reported an increase in serum and adipose levels of PCBs and other organochlorines (Charlier et al 2002;Chevrier et al 2000). This effect was not noted for chlordane-related compounds in a longitudinal study of Swedish women, where body mass index (BMI) and a recent change in weight were not associated with a difference in serum trans-nonachlor and oxychlordane levels, although these factors were associated with a difference in most serum PCB congener levels (Glynn et al 2003).…”

Section: Discussionmentioning

confidence: 94%

Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma.

Quintana

Delfino

Korrick

et al. 2004

Environ Health Perspect

103

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In this nested case-control study we examined the relationship between non-Hodgkin's lymphoma (NHL) and organochlorine pesticide exposure. We used a data set originally collected between 1969 and 1983 in the U.S. Environmental Protection Agency National Human Adipose Tissue Survey. Adipose samples were randomly collected from cadavers and surgical patients, and levels of organochlorine pesticide residues were determined. From the original study population, 175 NHL cases were identified and matched to 481 controls; 173 controls were selected from accident victims, and 308 from cases with a diagnosis of myocardial infarction. Cases and controls were mainly from cadavers (> 96%) and were matched on sex, age, region of residence within the United States, and race/ethnicity. Conditional logistic regression showed the organochlorine pesticide residue heptachlor epoxide to be significantly associated with NHL [compared with the lowest quartile: third quartile odds ratio (OR) = 1.82, 95% confidence interval (CI), 1.01-3.28; fourth quartile OR = 3.41, 95% CI, 1.89-6.16]. The highest quartile level of dieldrin was also associated with elevated NHL risk (OR = 2.70; 95% CI, 1.58-4.61), as were higher levels of oxychlordane, p,p´-DDE [p,p-1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene], and β-benzene hexachloride (ORs = 1.79, 1.99, and 2.47, respectively). The p-values for trends for these associations were significant. In models containing pairs of pesticides, only heptachlor epoxide and dieldrin remained significantly associated with risk of NHL. Limitations of this study include collection of samples after diagnosis and a lack of information on variables affecting organochlorine levels such as diet, occupation, and body mass index. Given the persistence of pesticides in the environment, these findings are still relevant today.

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Section: Discussionmentioning

confidence: 94%

Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma.

Quintana

Delfino

Korrick

et al. 2004

Environ Health Perspect

103

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“…Both chemotherapy (37;38) and changes in body weight (41;46) are reported to influence blood organochlorine levels. Results from sub-analyses which excluded men treated with chemotherapy or who experienced notable weight change were similar to those from the main analysis, but we cannot rule out other unmeasured effects of either treatment or disease that could result in either differential or non-differential exposure misclassification.…”

Section: Discussionmentioning

confidence: 99%

Serum Organochlorine Pesticide Residues and Risk of Testicular Germ Cell Carcinoma: A Population-Based Case-Control Study

Biggs¹,

Davis

Eaton³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Testicular germ cell carcinoma (TGCC) is the most common malignancy among men ages 20 to 34 years. Although the pathogenesis of TGCC is poorly understood, suboptimal androgen levels or impaired androgen signaling may play a role. Some persistent organochlorine pesticides commonly found in human tissue possess antiandrogenic properties. We examined whether the risk of TGCC is associated with serum levels of 11 organochlorine pesticides, including p,p ¶-DDE, and whether the p,p ¶-DDE-TGCC association is modified by CAG or GGN repeat polymorphisms in the androgen receptor gene. We conducted a population-based case-control study among 18-to 44-year-old male residents of three Washington State counties. Cases (n = 246) were diagnosed during 1999 to 2003 with a first, primary TGCC. Controls (n = 630) were men of similar age with no history of TGCC from the same population identified through random-digit telephone dialing. Questionnaires elicited information on demographic, medical, and lifestyle factors. A blood specimen provided serum for gas chromatographyhigh-resolution mass spectrometry analysis of organochlorine pesticide residues and DNA for genotyping. We observed no clear patterns between TGCC risk and concentrations of any of the organochlorines measured, nor did we observe that the risk associated with p,p ¶-DDE was modified by androgen receptor CAG (<23 versus z23 repeats) or GGN (<17 versus z17 repeats) genotype. This study does not provide support for the hypothesis that adult exposure to organochlorine pesticides is associated with risk of TGCC. Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy. (Cancer Epidemiol Biomarkers Prev 2008;17(8):2012 -8)

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“…1 In response to body weight loss, OC concentration increases in plasma 2,3 and they are more susceptible to exert their adverse effects on metabolism. In this regard, the increase in OC concentration induced by weight loss has been shown to be an independent predictor of the decrease in plasma tri-iodothyronine (T 3 ), 4 resting metabolic rate, 4 and skeletal muscle oxidative enzyme activity 5 resulting from weight loss.…”

Section: Introductionmentioning

confidence: 99%

Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution

et al. 2004

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The main objective of this study was to investigate the potential impact of body organochlorine (OC) pollution on the adaptive change in thermogenesis induced by body weight loss. Fat mass (FM), fat-free mass (FFM), and sleeping metabolic rate (SMR) were measured in obese individuals before and after a weight-reducing program. The measured values of SMR were then compared to those predicted from a reference equation established from FM and FFM in control subjects. Plasma OC, leptin, total tri-iodothyronine, and free thyroxine concentrations were also measured in obese subjects before and after weight loss. After weight loss, the measured decrease in SMR was greater than that predicted by changes in FM and FFM. Increased plasma OC concentration was the factor explaining the greatest proportion of the difference between predicted and measured SMR changes induced by body weight loss. OC pollution seems to be a new factor affecting the control of thermogenesis in some obese individuals experiencing body weight loss. IntroductionThe total body burden of organochlorines (OCs) is greater in obese than in lean individuals because of their increased body fat stores and plasma and adipose tissue OC concentration. 1 In response to body weight loss, OC concentration increases in plasma 2,3 and they are more susceptible to exert their adverse effects on metabolism. In this regard, the increase in OC concentration induced by weight loss has been shown to be an independent predictor of the decrease in plasma tri-iodothyronine (T 3 ), 4 resting metabolic rate, 4 and skeletal muscle oxidative enzyme activity 5 resulting from weight loss. Considering that OCs are also known to alter the functionality of mitochondria, 6 it is realistic to hypothesize that the increase in plasma OCs is a factor implicated in the adaptive decrease in thermogenesis occurring with weight loss. 7,8 To investigate this issue, we measured the sleeping metabolic rate (SMR) and its deviations from predicted values before and after weight loss in obese individuals. This allowed an estimation of adaptive thermogenesis, defined as the difference between the expected decrease in SMR due to the decreases of fat mass (FM) and fat-free mass (FFM) and the decrease in SMR really measured. This difference was then used as the dependent variable in a stepwise multiple regression analysis to compare the contribution of OCs to variations in thermogenesis to that of other factors known to affect thermogenesis in the context of a weight-reducing program. MethodsIn all, 58 men and 28 women with a wide range of body weight (47.5-146.1 kg) were used as control subjects to establish a reference equation predicting the SMR from gender, age, FM, and FFM. Eight men and seven women who gave their written consent to participate in a weight-loss program approved by the Laval University Ethics Committee and for whom all the variables of interest were available before and after weight loss were analyzed in the present study. The weight-loss program, which was conducted between 1995...

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Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants

Cited by 33 publications

References 22 publications

Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma.

Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma.

Serum Organochlorine Pesticide Residues and Risk of Testicular Germ Cell Carcinoma: A Population-Based Case-Control Study

Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution

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