Human exposure to endocrine disrupting chemicals and fertility: A case–control study in male subfertility patients

Hond, Elly Den; Tournaye, Herman; Sutter, Petra De; Ombelet, Willem; Baeyens, Willy; Cox, Bianca; Nawrot, Tim S.; Larebeke, N. Van; D’Hooghe, Thomas

doi:10.1016/j.envint.2015.07.017

Cited by 147 publications

(106 citation statements)

References 48 publications

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“…SHBG is produced and secreted by the liver into the blood where it binds sex steroids and regulates their bioavailability43. Hence, those with higher levels of SHBG may have less bioavailable and albumin-bound testosterone, which is associated with subfertility in men44 and atherosclerosis in postmenopausal women45. More importantly, SHBG is now regarded as a biomarker of the degree of inflammation in metabolic diseases43.…”

Section: Discussionmentioning

confidence: 99%

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

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We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin(SHBG) levels were measured. The results showed that median values (interquartile range) of BLLs were 44.00 μg/L (29.00–62.30) for men and 41.00 μg/L (27.00–59.81) for postmenopausal women. In linear regression, after adjusting for age, current smoking status, body mass index, systolic blood pressure, diabetes and blood cadmium level, TT (P for trend = 0.001) and SHBG (P for trend < 0.001) levels were still positively associated with BLLs in men. Meanwhile, significant positive associations were found for BLLs with SHBG (P for trend = 0.002), FSH (P for trend = 0.001) and LH (P for trend = 0.026) levels in postmenopausal women. Additionally, the association between BLL and SHBG was modified by dysglycaemia (P for interaction = 0.03) in postmenopausal women. In conclusion, BLLs were associated with reproductive hormone levels in the general population of Chinese men and postmenopausal women, which may have important implications for human health. Concerted efforts to reduce adult lead exposure are warranted.

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Section: Discussionmentioning

confidence: 99%

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

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“…Some of them can be oxidized or conjugated with glucuronic acid before being excreted in urine [11,12]. Several epidemiological studies have focused on the male health effects of phthalate exposure [13,14] and documented an association between phthalates metabolites levels, particularly mono n-butylphthalate (MnBP) and mono-(2-ethylhexyl) phthalate (MEHP) [15][16][17] and lowered sperm concentration, lower density and decreased motility, even if some controversies exist [18].In particular, for MEHP levels a negative association with sperm motility was observed. Other authors found as well an inverse association of monobenzylphthalate (MBzP) levels with sperm motility [19].Moreover, an interesting study [20] found a reduced semen quality, even at phthalate levels below the US EPA reference doses.…”

mentioning

confidence: 99%

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

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Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n-butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono-n-octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liquid chromatography/tandem mass spectrometry HPLC/MS/MS. The regression analysis showed that the semen volume was positively associated with MnBP, MnOP and BPA levels while was negatively associated with MiNP levels. The sperm concentration had a significant inverse relationship with MEP levels. A negative association was found between the use of plastic containers for food storage (p = 0.037) and semen volume (3.06 vs. 2.30 mL as average values, never vs daily). A significant positive correlation emerged (p < 0.005) between the consumption of canned food and the levels of BPA (2.81 vs. 0.14 µg/g creat as average values, daily vs. never) and between the use of perfumes and levels of MEP (389.86 vs. 48.68 µg/g creat, as average values, daily vs. never). No further statistically significant associations were found, even considering the working activity. Some evidence emerged about the possible link between exposure and seminal fluid quality: further case/control or prospective studies will allow us to confirm this causality hypothesis.

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“…In the results, the Leydig cells staining and AR-positive germ cell staining were significantly reduced at HD compared to the control, which may indicate male infertility. Two previously reported studies have attributed the decline in male fertility to EDC exposure, especially for the chlorinated compounds that are accused of inducing low sperm quality in men [33,34]. EDCs are extracellular agents that interfere with the synthesis, secretion, transport, metabolism, binding and elimination of natural blood hormones present in the body and are responsible for the homeostasis, reproduction, and developmental processes [35].…”

Section: Discussionmentioning

confidence: 99%

Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats

Mandal

Parvin

Joo

et al. 2020

IJERPH

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Triclosan (TCS) is a widely used chemical in personal care and household products as an antimicrobial agent but some studies have reported it as being estrogenic. We investigated the influence of TCS on the male reproductive system of postnatal pups. Lactating mother rats (Rattus norvegicus) were given daily doses of 0 mg, 3 mg, and 5 mg/kg/day from the day of delivery until 28 days, equivalent to their natural breastfeeding duration. At 28 days, the male pups of all three groups were sacrificed and their biochemical parameters evaluated. TCS-treated pups had decreased mRNA levels for 3β hydro-hydroxysteroid dehydrogenases (3βHSD), OCT3/4, and androgen receptor (AR) (p < 0.05). The higher dose (5 mg/kg/day) male pups exhibited more significantly affected germ cell maturation and decreased body weight. In summary, TCS-treated lactating mothers passed the deleterious effects to their untreated male pups as exhibited by reduced androgens synthesis and subsequently decreased sperm count.

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Human exposure to endocrine disrupting chemicals and fertility: A case–control study in male subfertility patients

Cited by 147 publications

References 48 publications

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats

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