Human exposure to metals. Pathways of exposure, biomarkers of effect, and host factors

Calderón, Jaqueline; Ortiz-Pérez, Deogracias; Yáñez, Leticia; Dı́az-Barriga, Fernando

doi:10.1016/s0147-6513(03)00053-8

Cited by 105 publications

(62 citation statements)

References 99 publications

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“…Mercury is a well-known, highly deleterious environmental pollutant with recognized mutagenic and teratogenic effects (Calderón et al, 2003;Tchounwou et al, 2003). It is accumulated by many aquatic organisms, transferred and magnified along the trophic chain (Watras and Bloom, 1992;Laporte et al, 1997;Lawson and Mason, 1998), eventually finding its way to economically important species and ultimately to Humans.…”

Section: Introductionmentioning

confidence: 99%

Pattern and pathways for mercury lifespan bioaccumulation in Carcinus maenas

Coelho

Reis

Ventura

et al. 2008

Marine Pollution Bulletin

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a b s t r a c tCarcinus maenas is an important and exploited natural resource in temperate estuaries, being consumed by local populations and also used as fish bait. Through bioaccumulation and bioamplification processes occurring in polluted estuarine ecosystems, this species may directly or indirectly represent a major pathway for Human contamination. No information is available on the overall lifespan bioaccumulation pattern of mercury for this species, which would be an invaluable tool for assessing the risks associated with C. maenas harvest in contaminated areas. Taking that in mind, the main objectives of this work were to clarify the lifespan bioaccumulation pattern of mercury for this species. A consistent lifespan accumulation pattern was found for this species, both for total and organic mercury, and coherent differences were found between genders, suggesting different physiological responses to contamination. From our results two scenarios emerge: (a) for low mercury contamination areas where the diet is the major pathway for metal uptake, with higher levels in muscle and hepatopancreas (twice as high as in gills) and higher organic mercury fractions (as high as 80-90% in muscle), crabs bioaccumulate with age and (b) on high contaminated areas, environmental exposure is predominant, with higher levels found in gills (reaching 0.8 mg kg À1 ), lower organic fractions and no mercury increment with age. Detoxification strategies, dietary differences and species mobility may account for these two accumulation patterns.

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Section: Introductionmentioning

confidence: 99%

Pattern and pathways for mercury lifespan bioaccumulation in Carcinus maenas

Coelho

Reis

Ventura

et al. 2008

Marine Pollution Bulletin

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“…Mercury is a highly deleterious environmental pollutant with recognized mutagenic and teratogenic effects, although data on the mechanisms of such effects are very sparse and controversial in the available literature (Ariza et al, 1994;Caldero´n et al, 2003;Tchounwou et al, 2003). Problems derived from mercury contamination are enhanced when mercury enters the food chain, the predominant pathway of human exposure to methylmercury, which is the most toxic form of mercury (Tchounwou et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Macroalgae response to a mercury contamination gradient in a temperate coastal lagoon (Ria de Aveiro, Portugal)

Coelho

Pereira

Duarte

et al. 2005

Estuarine, Coastal and Shelf Science

114

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Primary producers represent an important pathway for mercury incorporation in aquatic food webs. With eutrophication processes occurring worldwide, macroalgae may represent a substantial pool of mercury, as a result of its high growth rate and capacity to bind trace metals. The main aim of this work was to evaluate the response of the macroalgae to a human-induced environmental mercury gradient in a temperate coastal lagoon, by assessing the total and organic mercury contamination levels of the dominant species (Enteromorpha, Fucus and Gracilaria). Total mercury in the plant tissues ranged from 0.02 to 2.1 mg g ÿ1 dwt. Fucus was the most contaminated algae, followed by Gracilaria and Enteromorpha. As a whole, organic mercury never exceeded 15% of total mercury content, but tended to increase with distance to metal source on all macroalgae indicating complex physiological responses from these primary producers in areas of high and low mercury concentrations. Sessile macroalgae may be important mercury immobilisation agents, while free-floating algae (Enteromorpha) play an important role in mercury transport from contaminated areas (G10 g ha ÿ1 ) to other areas of the lagoon and even to coastal waters. Based on the present results the use of macroalgal biomass from contaminated areas for direct or indirect human use (e.g. agricultural, industrial and food purposes) may result in health risks, due to the high bioaccumulation capacity (as high as 10 4 the dissolved mercury concentrations).

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“…In this regard, DNA damage, which is induced by a variety of metals, could be used as a biomarker at polluted sites (Calderón et al, 2003). The lung is a target organ for cadmium toxicity (Lag et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Damaging effects of water-borne cadmium chloride on DNA of lung cells of immature mice

Yang

Ge²,

Zhang³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. We investigated the effects of cadmium on lung cell DNA in immature mice. The mice were randomly divided into four groups: control group, low-dose group (1/100 LD 50 ), middle-dose group (1/50 LD 50 ), and high-dose group (1/25 LD 50 ); they were supplied with cadmium chloride or control water for 40 days. Lung cells collected from sacrificed mice were used to evaluate the extent of DNA damage by comet assay. The ratio of tailing cells, DNA tail length, DNA comet length, DNA tail moment, DNA olive tail moment, and percentage of DNA in the comet tail were measured. The rate of tailing lung cells exposed to cadmium increased significantly; the low-concentration group had significantly (P < 0.05) higher rates, and the middle-and high-concentration groups had higher (P < 0.01) rates compared to the control. DNA tail length, DNA comet length, DNA tail moment, and DNA olive tail moment all increased with the increase in cadmium doses, but compared with those of the control group, no significant differences in low-dose group were found (P > 0.05), and the differences in middleand high-dose groups were all highly significant (P < 0.01). The degree of DNA damage also increased with the increase of the cadmium concentrations. We conclude that cadmium significantly increases DNA ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (4): 4323-4329 (2012) X.F. Yang et al. 4324 damage in lung cells of immature mice in a dose-dependent manner.

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Human exposure to metals. Pathways of exposure, biomarkers of effect, and host factors

Cited by 105 publications

References 99 publications

Pattern and pathways for mercury lifespan bioaccumulation in Carcinus maenas

Pattern and pathways for mercury lifespan bioaccumulation in Carcinus maenas

Macroalgae response to a mercury contamination gradient in a temperate coastal lagoon (Ria de Aveiro, Portugal)

Damaging effects of water-borne cadmium chloride on DNA of lung cells of immature mice

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