The transition to a low-carbon future in the O&G industry seeks a comprehensive understanding of the Human Factors Ecosystem, particularly in relation to human performance and process safety. This paper explores the critical role that human factors play in fostering an energy transition, highlighting how optimized human performance and enhanced process safety can significantly contribute to the industry's sustainability goals. The study delves into the interplay between human behavior, organizational culture, and technological advancements, emphasizing the need for a systemic approach to manage the inherent complexities and risks of high-stakes environments. By examining case studies and applying methodologies such as the Functional Resonance Analysis Method (FRAM), the paper illustrates how a systemic and integrative Human Factors approach can lead to more resilient and adaptable operations. The findings underscore the importance of integrating different disciplines into the strategic planning and operational frameworks of O&G companies to drive efficiency, safety, and environmental stewardship. This research provides valuable insights for industry leaders, policymakers, and safety professionals aiming to align human performance with the overarching goals of the energy transition, adopting practical cases studies of accident analysis, human reliability and risk analysis with FRAM.