As with most machines, the integral safety mechanism on firearms is vital to injury or fatality free operation. Presently, there is little or no standardisation in the design of these mechanisms. In this investigation, five existing designs found on both military and commercial rifles were evaluated ergonomically to determine the most effective characteristics for incorporation into future designs. The designs were evaluated experimentally on ease of use, visual effectiveness and operational impact. Three groups, representing a total of 30 subjects with widely varying experience, were selected. Results strongly suggest that safeties whose actuators are mounted within easy reach of the trigger finger are preferred and have the least operational impact. Subjects also preferred and were more adept at recognising safety status when the indicator was located on the receiver/barrel along the normal line of sight. Subjects more often correctly identified safety status when the indicator utilised colouring, was clearly marked and/or was in the normal line of sight. The results of this research prove that ergonomics can contribute to the understanding of firearm safety dynamics. The two essential components of safety mechanism design identified in this investigation, unambiguous status visibility and impact-free operation, are also likely to have implications in non-firearm safety mechanism design. This is particularly true for devices whose inadvertent operation can cause injury, as well as systems in which operational effectiveness can be jeopardised when attentiveness or operational control are lost in the process of actuating a poorly designed safety mechanism.