Human factors testing of the Quanta SC+ hemodialysis system: An innovative system for home and clinic use

Harasemiw, Oksana; Day, Clara; Milad, John; Grainger, James K.; Ferguson, Thomas; Komenda, Paul

doi:10.1111/hdi.12757

Cited by 9 publications

(13 citation statements)

References 26 publications

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“…Easy to use HHD machine (i.e., loading the bloodline, loading dialysis lines, connecting the patient, priming, ending treatment, disposing of consumables, manual washback, comprehension, and responding to the high venous pressure alarm) 82 …”

Section: Resultsmentioning

confidence: 99%

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Exploring stakeholders and their requirements in the process of home hemodialysis: A literature review

Khan

Pintelon

Martin

et al. 2021

Seminars in Dialysis

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Providing home hemodialysis (HHD) therapy is a complex process that not only requires the use of a complex technology but also involves a diverse group of stakeholders, and each stakeholder has their requirements and may not share a common interest. Bringing them together will require the alignment of their interests. A process management perspective can help to accomplish the alignment of their interests. To align their interests, it is crucial to identify interest groups and understand their interests. The main objective of this paper is to identify the stakeholders and represents their interests as a list of requirements in the HHD process. An extensive literature review has been carried out and PubMed was used for literature extraction. In total, 1848 articles were retrieved of which 80 have fulfilled the inclusion criteria. A large array of actors is identified and their interests/requirements at different stages of the HHD process are represented in the form of a list. They have both common and conflicting requirements in the HHD process. If these requirements are aligned and balanced, a stakeholder's driven treatment process will be developed and a real improvement will be achieved in the treatment process.

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Section: Resultsmentioning

confidence: 99%

“…Easy to use HHD machine (i.e., loading dialysis lines, loading the bloodline, priming, connecting the patient, ending treatment, responding to the air in the blood alarm, disposing of consumables, comprehension, and responding to the high venous pressure alarm) 82 …”

Section: Resultsmentioning

confidence: 99%

Exploring stakeholders and their requirements in the process of home hemodialysis: A literature review

Khan

Pintelon

Martin

et al. 2021

Seminars in Dialysis

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“…Previously published human factors testing work validates the design principles of the SC+ system in terms of patient usability with minimal training. 8 For this reason, the SC+ system is a well-suited hemodialysis device for patient use across a wide range of dialysis prescriptions in the home and in facilities. The device requires reverse-osmosis quality water and can be simply installed into the ring main of a dialysis clinic or with a single-station reverse-osmosis unit.…”

Section: Discussionmentioning

confidence: 99%

“…Quanta Dialysis Technologies (Alcester, UK) has developed SC+, a compact personal hemodialysis system designed and validated as easy to use by patients with a low user error rate after minimal training. 8 A key purported differentiator of the Quanta SC+ hemodialysis system is its ability to be used across a continuum of hemodialysis prescriptions – from conventional three times per week, as typically experienced by most patients globally, to the clinically-preferred frequent and long prescriptions. The primary objective of this study was to demonstrate the safety and efficacy of the SC+ system in a clinical setting using conventional thrice-weekly hemodialysis prescriptions.…”

Section: Introductionmentioning

confidence: 99%

Hemodialysis With the Quanta SC+: Efficacy and Safety of a Self-care Hemodialysis Machine

Komenda

Harper²,

Wilson

et al. 2020

Kidney Medicine

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Rationale & Objective Most kidney failure patients receive hemodialysis three times-per-week in a facility. More frequent and longer-duration dialysis prescriptions improve a number of key outcome measures. These prescriptions are best suited to self-care and home regimens. The Quanta SC+ hemodialysis system is a novel device with demonstrated ease of use for patients and healthcare practitioners through Human Factors Testing. The primary objective of this study is to report the efficacy and safety of the SC+ system using conventional hemodialysis prescriptions. Study Design Non-randomized, observational study Setting & Participants: Prevalent hemodialysis patients in 4 sites in the United Kingdom were recruited to switch from their current device to the SC+ system with no other changes to their prescription. Interventions SC+ hemodialysis system Outcomes Efficacy data were collected in terms of dialysis adequacy, urea reduction ratios, and net fluid removal accuracy. Results 60 patients were enrolled in the study resulting in 1,333 evaluable treatments. The threshold spKt/V of 1.2 was exceeded in 96.6 percent of treatments in patients receiving three-times weekly regimens, while the threshold stdKt/V of 2.1 was exceeded in 94% of treatments and 97.6% of treatments in patients without significant residual kidney function. Ultrafiltration accuracy was determined by measuring net fluid removal and validated to be within acceptable limits. The adverse event profile during treatment was typical of hemodialysis. There were no serious adverse events. Limitations Few patients on high-frequency treatment regimens were enrolled. Conclusions The SC+ system delivers safe and effective hemodialysis across a range of patients and dialysis prescriptions. It is one of the smallest systems available and has validated usability for patients to perform self-care safely with minimal training. This device may encourage patients to feel empowered to take on home hemodialysis, unlocking beneficial clinical and patient-reported outcome associated with these modalities.

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“…Although some have been adapted for home use, more recently manufacturers have begun focusing on machines specifically developed for home therapy use and patient operation [11,12]. Such an approach has necessitated an improved understanding of industrial design, human factors and ergonomics to ensure that the burden of undertaking treatment in the home is reduced for the patient and their care partner [13,14].…”

Section: Plos Onementioning

confidence: 99%

Enhancement of solute clearance using pulsatile push-pull dialysate flow for the Quanta SC+: A novel clinic-to-home haemodialysis system

Buckberry¹,

Hoenich

Krieter

et al. 2020

PLoS ONE

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Background and objective The SC+ haemodialysis system developed by Quanta Dialysis Technologies is a small, easy-to-use dialysis system designed to improve patient access to self-care and home haemodialysis. A prototype variant of the standard SC+ device with a modified fluidic management system generating a pulsatile push-pull dialysate flow through the dialyser during use has been developed for evaluation. It was hypothesized that, as a consequence of the pulsatile push-pull flow through the dialyser, the boundary layers at the membrane surface would be disrupted, thereby enhancing solute transport across the membrane, modifying protein fouling and maintaining the surface area available for mass and fluid transport throughout the whole treatment, leading to solute transport (clearance) enhancement compared to normal haemodialysis (HD) operation. Methods The pumping action of the SC+ system was modified by altering the sequence and timings of the valves and pumps associated with the flow balancing chambers that push and pull dialysis fluid to and from the dialyser. Using this unique prototype device, solute clearance performance was assessed across a range of molecular weights in two related series of laboratory bench studies. The first measured dialysis fluid moving across the dialyser membrane using ultrasonic flowmeters to establish the validity of the approach; solute clearance was subsequently measured using fluorescently tagged dextran molecules as surrogates for uraemic toxins. The second study used human blood doped with uraemic toxins collected from the spent dialysate of dialysis patients to quantify solute transport. In both, the performance of the SC+ prototype was assessed alongside reference devices operating in HD and pre-dilution haemodiafiltration (HDF) modes.

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Human factors testing of the Quanta SC+ hemodialysis system: An innovative system for home and clinic use

Cited by 9 publications

References 26 publications

Exploring stakeholders and their requirements in the process of home hemodialysis: A literature review

Exploring stakeholders and their requirements in the process of home hemodialysis: A literature review

Hemodialysis With the Quanta SC+: Efficacy and Safety of a Self-care Hemodialysis Machine

Enhancement of solute clearance using pulsatile push-pull dialysate flow for the Quanta SC+: A novel clinic-to-home haemodialysis system

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