Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

Revishchin, A. V.; Александрова, М. А.; Podgornyi, O. V.; Marei, M. V.; Полтавцева, Р. А.; Korochkin, L. I.; Степанов, Г. А.; Сухих, Г. Т.

doi:10.1007/s10517-005-0251-0

Cited by 2 publications

(1 citation statement)

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“…[10][11][12] Experimental studies in rat models have demonstrated the potential efficacy of fetal stem cells in treating liver diseases, kidney diseases, and diseases of the central nervous system. [13][14][15][16][17] The therapeutic effects of fetal stem cell may be related directly to embryo-specific growth factors, cytokines, and other signaling molecules that are able to activate recovery and survival in the recipient's own cells. 11 It is believed that introducing suspensions of fetal cells into the patient using network signaling can activate specialized and progenitor cells.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Tuganbekovа

Gaipov²,

Turebekov³

et al. 2015

Exp Clin Transplant

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Objectives: Proteinuria is a major cause of glomerulosclerosis progression in glomerular diseases, and the development of end-stage renal disease is more rapid in nephrotic patients than in nonnephrotic ones. The renal parenchyma is less regenerable because it is a tissue consisting of renal cells. Thus, stem cells obtained from fetal kidney tissue might be effective for reducing proteinuria and delaying glomerulosclerosis in these patients. Materials and Methods: This report presents preliminary data from a prospective cohort study that included 17 patients with chronic glomerulonephritis in stage 2 to 4 chronic kidney disease who completed 3 visits during 1 year of follow-up. Fetal renal stem cells (multiple cells in suspension) were injected into the patient every 6 months. Patients were divided into 2 groups according to their nephrotic status, and 24-hour maximal proteinuria was recorded for at least 6 months (first group with proteinuria < 3.5 g/24 h, and second group with proteinuria > 3.5 g/24 h). Results: During follow-up, group 1 was observed to have stable hemoglobin and total protein levels but significantly decreased albumin levels and glomerular filtration rates. In group 2, total protein with serum albumin significantly increased, and proteinuria and glomerular filtration rates significantly decreased. There was no significant difference in glomerular filtration rate decline between groups. Conclusions: Treatment with fetal renal stem cells significantly decreased proteinuria in nephrotic patients. However, this outcome also might have resulted from a reduction in glomerular filtration rate. Further studies with a larger number of patients and a control group would help to achieve better results that measure the efficacy of this treatment.

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