Human fluorescent profile of urine as a simple tool of mining in data from autofluorescence spectroscopy

Strong Dependence between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma

“…From every sample, we measured 12 synchronous spectra with Δλ 30 nm in the range 250–550, step 0.5 nm, excitation/emission slits 5/5 nm, and a scan speed of 1200 nm/min. The measurements were performed, and urine fluorescence profiles were constructed as previously published [ 2 ].…”

“…The optical properties of the biological system obtained by fluorescence analysis reflect some of the physicochemical properties of the metabolites. Urine is a multicomponent mixture of different fluorophores and nonfluorescent metabolites [ 1 , 2 , 3 , 4 ].…”

“…In recent years, progress has been made in the use of fluorescence spectroscopic techniques for the diagnosis of selected oncological diseases, such as ovarian cancer [ 2 , 6 , 7 ], pancreatic cancer [ 8 ], breast cancer [ 9 , 10 ], bladder cancer [ 11 ].…”

“…The use of urinary fluorescence analysis offers the possibility to detect urinary metabolites potentially associated with the neoplastic process, which could provide a new direction in the current search for predictive and prognostic markers [ 2 , 11 , 19 , 20 ]. In our previous studies, we have confirmed the role of fluorescence spectroscopy as a useful diagnostic tool with high-efficiency in ovarian cancer [ 7 ] as well as the feasibility of synovial fluid fluorescence fingerprinting to identify disease-specific profiles of synovial fluid metabolites [ 21 ].…”

A dual-caged resorufin probe for rapid screening of infections resistant to lactam antibiotics

“…[31][32][33][34][35][36][37] Nevertheless, the autofluorescence in patient specimens ranging from violet to green and yellow remains a major roadblock for direct sample analysis with these probes. [38][39][40] Attempts have been made to circumvent the issue by using redshift fluorophores. The β-LEAF assay, for instance, employed a unique quenching-dequenching mechanism with benzo[a]phenothiazines and could generate red fluorescence (Excitation 640/Emission 700) upon β-lactamase activation.…”