Human gastric lipase: ontogeny and variations in children

Sarles, J.; Moreau, Hervé; Verger, Robert

doi:10.1111/j.1651-2227.1992.tb12284.x

Cited by 48 publications

(12 citation statements)

References 11 publications

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“…reported that in seven children with gastritis, the activity of HGL was normal, while in the two remaining children, only a trace HGL activity was found. They concluded that the activity of HGL is only rarely reduced in patients with gastritis [13]. In our study, the age of the patients was in a similar range (adolescents), and all of them had gastritis.…”

Section: Discussionsupporting

confidence: 61%

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Gastric Lipase Secretion in Children with Gastritis

et al. 2013

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Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10), the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14) and the control group including healthy adolescents (n = 14). Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005) and the control group (p < 0.005). Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003) and the HPG group (p < 0.01). We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.

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Section: Discussionsupporting

confidence: 61%

“…in 1992 [13]. The authors studied a group of 55 children aged from zero to 17 years, including only nine patients with gastritis.…”

Section: Discussionmentioning

confidence: 99%

Gastric Lipase Secretion in Children with Gastritis

et al. 2013

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“…The low pH is known to favor the release of Ca 2ϩ (16)(17)(18), and casein is precipitated. The acid lipase hydrolyses triglycerides, and fatty acids are released (25,26). By chance, we happened to purify the apoptosisinducing form of ␣-lactalbumin from human milk after precipitation of casein at low pH, thus mimicking the conditions in the stomach of the breast-fed child (7,27).…”

Section: Discussionmentioning

confidence: 99%

Conversion of α-lactalbumin to a protein inducing apoptosis

Svensson

Håkansson

Mossberg

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

335

437

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In this study ␣-lactalbumin was converted from the regular, native state to a folding variant with altered biological function. The folding variant was shown to induce apoptosis in tumor cells and immature cells, but healthy cells were resistant to this effect. Conversion to HAMLET (human ␣-lactalbumin made lethal to tumor cells) required partial unfolding of the protein and a specific fatty acid, C18:1, as a necessary cofactor. Conversion was achieved with ␣-lactalbumin derived from human milk whey and with recombinant protein expressed in Escherichia coli. We thus have identified the folding change and the fatty acid as two key elements that define HAMLET, the apoptosis-inducing functional state of ␣-lactalbumin. Although the environment in the mammary gland favors the native conformation of ␣-lactalbumin that serves as a specifier in the lactose synthase complex, the conditions under which HAMLET was formed resemble those in the stomach of the nursing child. Low pH is known to release Ca 2؉ from the highaffinity Ca 2؉ -binding site and to activate lipases that hydrolyze free fatty acids from milk triglycerides. We propose that this single amino acid polypeptide chain may perform vastly different biological functions depending on its folding state and the in vivo environment. It may be speculated that molecules like HAMLET can aid in lowering the incidence of cancer in breast-fed children by purging of tumor cells from the gut of the neonate.

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“…HGL is not only the first lipase found along the gastro-intestinal tract, it is also produced at high levels in the early life while the production of pancreatic enzymes and bile is still limited [12][13][14]. In the neonatal context, lipid digestion is crucial for cerebral and global development and growth, and HGL appears as a central enzyme in this process [12,14].…”

Section: Introductionmentioning

confidence: 99%

“…In the neonatal context, lipid digestion is crucial for cerebral and global development and growth, and HGL appears as a central enzyme in this process [12,14]. HGL is able to initiate the lipolysis of milk fat globules, what is not readily done by pancreatic lipase [15].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of gastric lipase onto multicomponent model lipid monolayers with phase separation

Bourlieu-Lacanal

Pabœuf

Chever

et al. 2016

Colloids and Surfaces B: Biointerfaces

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (ellipsometry, tensiometry and atomic force microscopy), it was evidenced that rDGL partitions toward liquid expanded phase and at phase boundaries. rDGL gets adsorbed at several levels of insertion suggesting molecular cooperation that may favor insertion and strongly impacts on the lipid phase lateral organization. The addition of phosphatidylserine, negatively charged, reinforced adsorption; hence besides hydrophobic interactions and as further investigated through surface potential modeling, rDGL adsorption is favored by electrostatic interactions.

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Human gastric lipase: ontogeny and variations in children

Cited by 48 publications

References 11 publications

Gastric Lipase Secretion in Children with Gastritis

Gastric Lipase Secretion in Children with Gastritis

Conversion of α-lactalbumin to a protein inducing apoptosis

Adsorption of gastric lipase onto multicomponent model lipid monolayers with phase separation

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