Human gastric myoelectric activity and gastric emptying following gastric surgery and with pacing

Hocking, Michael P.; Vogel, Stephen B.; Sninsky, Charles A.

doi:10.1016/0016-5085(92)91439-b

Cited by 137 publications

(116 citation statements)

References 20 publications

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“…Gastric electrical activity consists of two components: slow waves and spike potentials (14). Slow waves are omnipresent and occur at regular intervals whether or not the stomach contracts.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

Zhu¹,

Sallam²,

Chen³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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The aim of this study was to determine the effects and mechanism of synchronized gastric electrical stimulation (SGES) on gastric contractions and gastric emptying. The first experiment was designed to study the effects of SGES on antral contractions in four randomized sessions. Sessions 1 (control) and 2 (atropine) were performed in the fasting state, composed of three 30-min periods (baseline, stimulation, and recovery). Sessions 3 (control) and 4 (SGES performed during 2nd 20-min period) were performed in the fed state, consisting of two 20-min periods; glucagon was injected after the first 20-min recording. The second experiment was designed to study the effect of SGES on gastric emptying and consisted of two sessions (control and SGES). SGES was delivered with train duration of 0.5–0.8s, pulse frequency of 40 Hz, width of 2 ms, and amplitude of 4 mA. We found that 1) SGES induced gastric antral contractions in the fasting state. The motility index was 1.3 ± 0.5 at baseline and 6.1 ± 0.7 ( P = 0.001) during SGES. This excitatory effect was completely blocked by atropine. 2) SGES enhanced postprandial antral contractions impaired by glucagon. 3) SGES significantly accelerated glucagon-induced delayed gastric emptying. Gastric emptying was 25.5 ± 11.3% without SGES and 38.3 ± 10.7% with SGES ( P = 0.006 vs. control). This novel method of SGES induces gastric antral contractions in the fasting state, enhances glucagon-induced antral hypomotility in the fed state, and accelerates glucagon-induced delayed gastric emptying. The effect of SGES on antral contractions is mediated via the cholinergic pathway.

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Section: Discussionmentioning

confidence: 99%

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

Zhu¹,

Sallam²,

Chen³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…[33][34][35][36] Normalization of dysrhythmia was also reported in patients with gastroparesis and postsurgical patients using the same method of GES. 37,38 While the exact mechanisms involved in the normalization of gastric dysrhythmia with long pulse/low frequency GES are unclear, it is known that it does not involve the vagal or cholinergic pathway. 32,36 A recent study reported the entrainment of slow waves in the absence of interstitial cells of Cajal (ICC) in mice, suggesting that pacing can be achieved without ICC.…”

Section: Alterations Of Gastric Slow Wavesmentioning

confidence: 99%

Systematic review: applications and future of gastric electrical stimulation

Zhang

Chen

2006

Aliment Pharmacol Ther

106

114

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“…GES has been investigated as a therapeutic option in the management of refractory gastroparesis (1,12,15,18,20) and morbid obesity (6 -8). A number of reports is available in the literature on GES with long pulses, demonstrating beneficial effects of this approach on gastric motor and sensory functions (3,9,16,18,20,22,28). However, little is known on the effects of GES on other organs of the gut.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of stimulation pulse width, GES can be classified into three categories: long pulses (on the order of milliseconds), short pulses (in the order of microseconds), and pulse trains. Although some of the results are still controversial, the majority of these studies seems to indicate that GES with long pulses at a low frequency (close to or slightly higher than intrinsic gastric slow-wave frequency) is able to normalize gastric dysrhythmias, entrain gastric slow waves, and accelerate gastric emptying (3,10,16,18,20,22). GES with short pulses at a high frequency (4 times or much higher than intrinsic gastric slow waves) is able to significantly reduce symptoms of nausea and vomiting but is minimally effective on gastric motility (1,5,9,11,12).…”

mentioning

confidence: 99%

Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs

Liu¹,

Wang²,

Chen³

2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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. Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs. Am J Physiol Gastrointest Liver Physiol 288: G1195-G1198, 2005. First published February 3, 2005 doi:10.1152/ajpgi.00554.2004.-Gastric electrical stimulation (GES) has been shown to alter motor and sensory functions of the stomach. However, its effects on other organs of the gut have rarely been investigated. The study was performed in 12 dogs implanted with two pairs of electrodes, one on the serosa of the stomach and the other on the colon. The study was composed of two experiments. Experiment 1 was designed to study the effects of GES on rectal tone and compliance in nine dogs compared with colonic electrical stimulation (CES). Rectal tone and compliance were assessed before and after GES or CES. Experiment 2 was performed to study the involvement of sympathetic pathway in 8 of the 12 dogs. The rectal tone was recorded for 30 -40 min at baseline and 20 min after intravenous guanethidine. GES or CES was given for 20 min 20 min after the initiation of the infusion. It was found that both GES and CES reduced rectal tone with comparable potency. Rectal compliance was altered neither with GES, nor with CES. The inhibitory effect of GES but not CES on rectal tone was abolished by an adrenergic blockade, guanethidine. GES inhibited rectal tone with a comparable potency with CES but did not alter rectal compliance. The inhibitory effect of GES on rectal tone is mediated by the sympathetic pathway. It should be noted that electrical stimulation of one organ of the gut may have a beneficial or adverse effect on another organ of the gut. gastric electrical stimulation; colonic electrical stimulation; rectal motility; sympathetic nerve THE EFFECTS OF GASTRIC ELECTRICAL stimulation (GES) on symptoms and gastric functions have received increasing scrutiny. A number of studies has been performed to investigate the effects of GES on gastric motility, gastric emptying, and gastrointestinal symptoms in both dogs and humans (1, 3, 5, 9 -12, 15, 16, 18, 20 -22). On the basis of stimulation pulse width, GES can be classified into three categories: long pulses (on the order of milliseconds), short pulses (in the order of microseconds), and pulse trains. Although some of the results are still controversial, the majority of these studies seems to indicate that GES with long pulses at a low frequency (close to or slightly higher than intrinsic gastric slow-wave frequency) is able to normalize gastric dysrhythmias, entrain gastric slow waves, and accelerate gastric emptying (3,10,16,18,20,22). GES with short pulses at a high frequency (4 times or much higher than intrinsic gastric slow waves) is able to significantly reduce symptoms of nausea and vomiting but is minimally effective on gastric motility (1,5,9,11,12). GES with pulse trains was noted to accelerate the movement of gastric solid contents in anesthetized dogs (21) and have a therapeutic role for the treatment of obesity (6 ...

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Human gastric myoelectric activity and gastric emptying following gastric surgery and with pacing

Cited by 137 publications

References 20 publications

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

Systematic review: applications and future of gastric electrical stimulation

Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs

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