Human GH pulsatility: An ensemble property regulated by age and gender

Veldhuis, Johannes D.; Bowers, Cyril Y.

doi:10.1007/bf03345229

Cited by 75 publications

(34 citation statements)

References 107 publications

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“…Age, sex, fasting, sleep, sex steroid availability and hypothalamo-pituitary feedback by IGF-1 are all factors responsible for variation in GH pulse amplitude and/or regularity. 41 Because IGF-1 depletion typically unleashes GH secretion, the elevation in IGF-1 levels following the first infliximab infusion could account for the reduced variability in GH values at T1, while the drop in IGF-1 concentrations could be responsible for the rebounding high variability at T3 and T4. However, in this context, it is not possible to explain the greatest variability in GH values observed at T2.…”

Section: Discussionmentioning

confidence: 99%

Infliximab reverses growth hormone resistance associated with inflammatory bowel disease

Gentilucci¹,

Caviglia

Picardi³

et al. 2005

Aliment Pharmacol Ther

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SUMMARYBackground: Increasing evidence shows that inflammation plays a major role in the aetiology of catabolism and wasting observed in inflammatory bowel disease via growth hormone resistance. Aim: To evaluate the effect of infliximab treatment on the growth hormone/insulin-like growth factor-1 axis. Methods: Fourteen adults with active Crohn's disease or ulcerative colitis underwent three infliximab infusions at a dose of 5 mg/kg for induction of remission, plus two maintenance infusions 8 weeks apart. Blood samples were collected for the analysis of serum growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding protein-3 and acid labile subunit. Results: Serum insulin-like growth factor-1 and insulinlike growth factor-binding protein-3 concentrations, which were significantly lower in inflammatory bowel disease patients before treatment compared with con-

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Section: Discussionmentioning

confidence: 99%

Infliximab reverses growth hormone resistance associated with inflammatory bowel disease

Gentilucci¹,

Caviglia

Picardi³

et al. 2005

Aliment Pharmacol Ther

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“…In the present study, nonhypophysectomized mice were studied. In normal rodents, as it occurs in several species, GH secretion is sexually dimorphic (Jansson et al 1985, MacLeod et al 1991, Veldhuis & Bowers 2003. A key difference between male and female GH profiles is the sustained interpulse interval with little or no detectable circulating GH characteristic of adult males (Jansson et al 1985, MacLeod et al 1991, Jaffe et al 1998.…”

Section: Effects Of Different Gh Administration Protocols On the Exprmentioning

confidence: 99%

GH administration patterns differently regulate epidermal growth factor signaling

Díaz

Miquet

Rossi

et al. 2014

Journal of Endocrinology

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Current GH administration protocols imply frequent s.c. injections, resulting in suboptimal compliance. Therefore, there is interest in developing delivery systems for sustained release of the hormone. However, GH has different actions depending on its continuous or pulsatile plasma concentration pattern. GH levels and circulating concentration patterns could be involved in the regulation of epidermal growth factor receptor (EGFR) expression in liver. Aberrant expression of this receptor and/or its hyperactivation has been associated with the pathogenesis of different types of carcinoma. Considering that one of the adverse effects associated with GH overexpression and chronic use of GH is the increased incidence of malignancies, the aim of this study was to analyze the effects of GH plasma concentration patterns on EGFR expression and signaling in livers of mice. For this purpose, GH was administered by s.c. daily injections to produce an intermittent plasma pattern or by osmotic pumps to provoke a continuously elevated GH concentration. Intermittent injections of GH induced upregulation of liver EGFR content, augmented the response to EGF, and the induction of proteins involved in promotion of cell proliferation in female mice. In contrast, continuous GH delivery in male mice was associated with diminished EGFR in liver and decreased EGF-induced signaling and expression of early genes. The results indicate that sustained delivery systems that allow continuous GH plasma patterns would be beneficial in terms of treatment safety with regard to the actions of GH on EGFR signaling and its promitogenic activity.

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“…Few years ago, two papers were published showing comparable results with other series with the bridge strategy. 2,3 In the latter publication, in Alimentary Pharmacology and Therapeutics, the long-term clinical outcome of a larger series of patients with steroid-refractory UC and initial response to i.v. CsA, subsequently treated with azathioprine and no oral CsA was evaluated.…”

Section: Is Oral Ciclosporin Necessary To Switch From IV To Thiopurmentioning

confidence: 99%

Associations between the IGF system and inflammatory markers in inflammatory bowel disease: authors’ reply

Gentilucci

Picardi

Caviglia³

et al. 2006

Aliment Pharmacol Ther

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SIRS, We are most grateful to Grønbaek and Eivindson for the interest in our article, and we are pleased to reply to their comments.First of all, based on the criticism raised, we have now performed correlation analyses between the GH/insulin-like growth factor (IGF)-1 axis components and markers of inflammation at each individual time point, but no significant results were obtained. We had not, in fact, previously performed these analyses for one simple reason: as documented by the studies cited, 1, 2 it is not reasonable to expect significant correlations between the GH/IGF-1 axis components and markers of inflammation in inflammatory bowel disease (IBD) patients when the sample is limited in size, as too many factors other than inflammation are known to influence the endocrine axis, i.e. age, gender, nutritional status, other hypothalamic peptides, sex steroid availability, etc. 3As clearly emerges in Figure 1(a/b) and, as has been correctly pointed out, correlation analyses have been carried out pooling data from different time points. We agree with Eivindson and Grønbaek that, statistically, this is not the most appropriate method when seeking correlations, because not all the observations are independent, and results can be affected by time trends. However, we would explain why we were persuaded to conduct this kind of analysis. Also in previous studies by Eivindson et al.,4 and by Street et al., 5 with a con-

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Human GH pulsatility: An ensemble property regulated by age and gender

Cited by 75 publications

References 107 publications

Infliximab reverses growth hormone resistance associated with inflammatory bowel disease

Infliximab reverses growth hormone resistance associated with inflammatory bowel disease

GH administration patterns differently regulate epidermal growth factor signaling

Associations between the IGF system and inflammatory markers in inflammatory bowel disease: authors’ reply

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