Human Glucose Transporters in Renal Glucose Homeostasis

Sędzikowska, Aleksandra; Szablewski, Leszek

doi:10.3390/ijms222413522

Cited by 21 publications

(9 citation statements)

References 126 publications

(202 reference statements)

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“…Following its uptake into beta-cells, STZ triggers oxidative stress, eventually causing the pancreatic β-cells to undergo necrotic cell death, resulting in hypoinsulinemia and hyperglycemia ( Choudhari et al, 2017 ). Additionally, GLUT2 transporters are not only expressed in pancreatic β-cells, but also in the epithelial cells of the kidneys and hepatocytes ( Sędzikowska and Szablewski, 2021 ; Yang et al, 2022 ). Thus, administration of STZ may result in nephro- and hepatotoxicity along with its potential to damage pancreatic β-cells ( Wszola et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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Hypertension and diabetes mellitus are among the most prevalent diseases affecting people from all walks of life. Medicinal herbs have garnered interest as potential agents for the prevention and treatment of diabetes mellitus and hypertension due to their multiple beneficial effects. Piper sarmentosum Roxb. (PS) is an edible medicinal plant that has been traditionally used in Asia for treating hypertension and diabetes mellitus. This review is aimed to provide comprehensive information from the literature on the effects of PS on hypertension and diabetes mellitus. A computerized database search was performed on Scopus, PubMed and Web of Science databases with the following set of keywords: Piper sarmentosum AND diabetes mellitus OR diabetic OR diabetes OR hyperglyc*emia OR blood glucose OR HbA1c OR glycated h*emoglobin OR h*emoglobin A1c OR hyperten* OR blood pressure. A total of 47 articles were screened and 14 articles published between the years 1998 until 2021 were included for data extraction, comprising of six articles on antihypertensive and eight articles on antidiabetic effects of PS. These studies consist of two in vitro studies and eleven in vivo animal studies. Meta-analysis of three studies on hypertension showed that PS versus no treatment significantly lowered the systolic blood pressure with mean difference (MD) −39.84 mmHg (95% confidence interval (CI) −45.05, −34.62; p < 0.01), diastolic blood pressure with MD −26.68 mmHg (95% CI −31.48, −21.88; p < 0.01), and mean arterial pressure with MD −30.56 mmHg (95% CI −34.49, −26.63; p < 0.01). Most of the studies revealed positive effects of PS against hypertension and diabetes mellitus, suggesting the potential of PS as a natural source of antidiabetic and antihypertensive agents.

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Section: Discussionmentioning

confidence: 99%

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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“…GLUT1 and GLUT3 have the highest affinities for glucose, GLUT2 has the lowest affinity, and the glucose affinities of the rest are between those of GLUT1, 2, and 3. GLUT1 plays an important role in kidney and tumor cell metabolism and is closely related to glycolysis activity ( 65 ). In laryngeal carcinoma cells, the expression of GLUT1 is positively correlated with that of E-cadherin and negatively correlated with that of vimentin, indicating that GLUT1 is involved in EMT ( 66 ).…”

Section: The Regulatory Mechanism Of Hif-1α In Renal Fibrosismentioning

confidence: 99%

Molecular mechanisms underlying the role of hypoxia-inducible factor-1 α in metabolic reprogramming in renal fibrosis

et al. 2022

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Renal fibrosis is the result of renal tissue damage and repair response disorders. If fibrosis is not effectively blocked, it causes loss of renal function, leading to chronic renal failure. Metabolic reprogramming, which promotes cell proliferation by regulating cellular energy metabolism, is considered a unique tumor cell marker. The transition from oxidative phosphorylation to aerobic glycolysis is a major feature of renal fibrosis. Hypoxia-inducible factor-1 α (HIF-1α), a vital transcription factor, senses oxygen status, induces adaptive changes in cell metabolism, and plays an important role in renal fibrosis and glucose metabolism. This review focuses on the regulation of proteins related to aerobic glycolysis by HIF-1α and attempts to elucidate the possible regulatory mechanism underlying the effects of HIF-1α on glucose metabolism during renal fibrosis, aiming to provide new ideas for targeted metabolic pathway intervention in renal fibrosis.

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“…Four types of glucose transporters are involved in glucose reabsorption in the human kidneys: sodium–glucose cotransporters (SGLT) 1 and 2 and glucose transporters (GLUT) 1 and 2 [ 4 , 5 ]. SGLT2 is predominantly expressed in the anterior half of the proximal tubule (the S1 and S2 segments) and has a low affinity and high transport capacity for glucose.…”

Section: Introductionmentioning

confidence: 99%

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption

Unno

Taguchi

Takagi³

et al. 2023

IJMS

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The sodium–glucose cotransporter 2 (SGLT2) mainly carries out glucose reabsorption in the kidney. Familial renal glycosuria, which is a mutation of SGLT2, is known to excrete glucose in the urine, but blood glucose levels are almost normal. Therefore, SGLT2 inhibitors are attracting attention as a new therapeutic drug for diabetes, which is increasing worldwide. In fact, SGLT2 inhibitors not only suppress hyperglycemia but also reduce renal, heart, and cardiovascular diseases. However, whether long-term SGLT2 inhibition is completely harmless requires further investigation. In this context, mice with mutations in SGLT2 have been generated and detailed studies are being conducted, e.g., the SGLT2−/− mouse, Sweet Pee mouse, Jimbee mouse, and SAMP10-ΔSglt2 mouse. Biological changes associated with SGLT2 mutations have been reported in these model mice, suggesting that SGLT2 is not only responsible for sugar reabsorption but is also related to other functions, such as bone metabolism, longevity, and cognitive functions. In this review, we present the characteristics of these mutant mice. Moreover, because the relationship between diabetes and Alzheimer’s disease has been discussed, we examined the relationship between changes in glucose homeostasis and the amyloid precursor protein in SGLT2 mutant mice.

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Human Glucose Transporters in Renal Glucose Homeostasis

Cited by 21 publications

References 126 publications

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

Molecular mechanisms underlying the role of hypoxia-inducible factor-1 α in metabolic reprogramming in renal fibrosis

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption

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