Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population

Abstract

These findings suggest that the GSTA1 and GSTT1 polymorphisms are associated with prostate cancer susceptibility, especially among smokers.

GSTA1 (glutathione S-transferase alpha 1)

“…Note Genetic variants of GSTA1 and GSTT1 may modify prostate cancer risk, especially among smokers (Komiya et al, 2005).…”

Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

“…Of these studies, 9 reported on Caucasians, and 9 reported on East Asians. Studies were carried out in Japan (Murata et al, 2001;Nakazato et al, 2003;Komiya et al, 2005), China (Guan et al, 2005;Lai et al, 2005;Wang et al, 2005;Yang et al, 2006;Li et al, 2008), India ( Vijayalakshmi et al, 2005;Srivastava et al, 2005;Mittal et al, 2006;Thakur et al, 2011;Kumar et al, 2011), South Korea (Kwon et al, 2011), Iran (Ashtiani et al, 2011;Safarinejad et al, 2011) and Turkey (Aktas et al, 2004;Silig et al, 2006). A list of details abstracted from the studies included in the meta-analysis is provided through Table 1.…”

The GSTT1 Null Genotype Contributes to Increased Risk of Prostate Cancer in Asians: a Meta-analysis

“…The most common variant of GSTT1 gene is homozygous deletion (null genotype), which has been suggested to be associated with the loss of enzyme activity, increased vulnerability to cytogenetic damage and oxidative DNA damage and resulted in the susceptibility to prostate cancer (Hayes and Strange, 2000). Many studies have investigated the association between GSTT1 null genotype and risk of prostate cancer, but the impact of GSTT1 null genotype on prostate cancer in Asians was still unclear owing to the obvious inconsistence among those studies (Murata et al, 2001;Nakazato et al, 2003;Mittal et al, 2004;Komiya et al, 2005;Srivastava et al, 2005;Kwon et al, 2011). This study aimed to quantify the strength of association between GSTT1 null genotype and risk of prostate cancer.…”

“…With our search criterion, 67 individual records were found, and 11 studies with a total of 3,118 subjects were finally included into this meta-analysis (Murata et al, 2001;Nakazato et al, 2003;Mittal et al, 2004;Komiya et al, 2005;Srivastava et al, 2005;Mittal et al, 2006;Yang et al, 2006;Ashtiani et al, 2011;Kumar et al, 2011;Kwon et al, 2011;Thakur et al, 2011). All included studies were English language literature.…”