Human Growth Hormone Secretion after Exercise and Oral Glucose Administration in Patients with Short Stature

Selective impairment of growth hormone response to physiological stimuli.

“…1. who were not HGH deficient, in agreement with data of Okada et al (1972), the ease of performance is such that discomfort of hospitalization and multiple venepunctures can be avoided in a significant rsproportion of short subjects. An abnormal exercise ,' / response can be followed logically by assessment of a single sleeping HGH level using relatively accessible equipment, and more complex and uncomfortable /' / procedures can consequently be reserved for 0/3rd confirmation in the comparatively small group of .," centile nonresponders to physiological stimuli.…”

Hormonal Responses to Exercise and Training: A Short Review

“…Some have reported potentiation of the GH peak at exhaustion after training (Hartley et al, 1972b). Since exercise is a simple and safe stimulus to GH release a number of workers have studied its use as a clinical screening test for G H deficiency (Okada et al, 1972;Lacey et al, 1973;Lin & Tucci, 1974;Sutton & Lazarus, 1976;Eisenstein et al, 1978;Johnsonbaugh et al, 1978;Liberman et al, 1979). Intensive, well controlled exercise may exclude GH deficiency (by a response of > 20 mu/]) in 68% of children with short stature (Lacey et al, 1973), but less well controlled exercise is unreliable (Lin & Tucci, 1974); close supervision is therefore necessary, rather negating the advantage of simplicity.…”

Re-evaluation of exercise as a screening test for ruling out human growth hormone deficiency.

“…Raiti et al, 1967;Maclaren et al, 1974 (Frantz et al, 1965) and age (Sukker et al, 1968) and often shows false negative results (Keenan et al, 1972;Lacey et al, 1973;Buckler 1973;Hansen 1973;Lin et al, 1974;Okada et al, 1972), but it has been used as a screening test to assure normal HGH secretion (Buckler 1972;Keenan et al, 1972;Lacey et al, 1973;Hansen 1973;Lin et al, 1974 patient developed in height by more than 15 cm 3 years, it was decided that HGH deficiency could be ruled out. HGH level during the exercise test increased to more than 5ng/ml in 20 of the 27 children, but not in the remaining 7.…”