Human Gut Microbiota Associated with Obesity in Chinese Children and Adolescents

Hou, Yaping; He, Qingqing; Ouyang, Hongwei; Peng, Haishan; Wang, Qun; Li, Jie; Lv, Xiao‐Fei; Zheng, Yinan; Li, Shao-Chuan; Liu, Hailiang; Yin, Aihua

doi:10.1155/2017/7585989

Cited by 124 publications

(126 citation statements)

References 43 publications

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“…Interestingly, all three bacteria have been linked with host metabolism. Coprobacillus was reported to be enriched in healthy individuals compared to obese individuals and was proposed as a novel probiotic due to its association with a healthy gut microbiome (34, 35). Dorea was found to be more abundant in lean than obese individuals (36)and Dorea longicatena was included as a component of the RePOOPulate stool substitute being developed as a treatment for Clostridium difficile (37).…”

Section: Resultsmentioning

confidence: 99%

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

Torres

Ho²,

Arroyo³

et al. 2018

Preprint

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48Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 49 10% of reproductive-aged women worldwide. Diagnosis requires two of the following: 50 hyperandrogenism, oligo/anovulation and polycystic ovaries. In addition to reproductive 51 dysfunction, many women with PCOS display metabolic abnormalities associated with 52hyperandrogenism. Recent studies have reported that the gut microbiome is altered in women 53with PCOS and rodent models of the disorder. However, it is unknown whether the gut 54 microbiome plays a causal role in the development and pathology of PCOS. Given its potential 55role, we hypothesized that exposure to a healthy gut microbiome would protect against 56 development of PCOS. A co-housing study was performed using a letrozole-induced PCOS 57 mouse model that recapitulates many reproductive and metabolic characteristics of PCOS. Since 58 mice are coprophagic, co-housing results in repeated, non-invasive inoculation of gut microbes 59 in co-housed mice via the fecal-oral route. In contrast to letrozole-treated mice housed together, 60letrozole-treated mice co-housed with placebo mice showed significant improvement in both 61reproductive and metabolic PCOS phenotypes. Using 16S rRNA gene sequencing, we observed 62 that the gut microbial composition of letrozole-treated mice co-housed with placebo mice 63 differed from letrozole mice housed together. In addition, our analyses identified several 64 bacterial taxa including Coprobacillus, Dorea and Adlercreutzia associated with the improved 65PCOS phenotype in letrozole-treated mice co-housed with placebo mice. These results indicate 66 that disruption of the gut microbiome may play a causal role in PCOS and that manipulation of 67 the gut microbiome may be a potential treatment option for PCOS. 68 69Significance: 70 71PCOS is a common cause of female infertility and ~80% of women with PCOS have metabolic 72 dysregulation that predisposes them to type 2 diabetes and cardiovascular disease. Since 73 treatment options for the metabolic symptoms of PCOS are limited, there is a need to develop 74 novel therapeutic options. The gut microbiome has emerged as an important player in human 75health and has been shown to play a causal role in obesity. In this study, we found that exposure 76to a healthy gut microbiome through co-housing protected against the development of 77reproductive and metabolic dysregulation in a PCOS mouse model. These results suggest that 78 manipulation of the gut microbiome may be a potential treatment option for women with PCOS. 79 80Introduction: 81 82Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 83 10% of women worldwide (1). Diagnosis of PCOS, using the Rotterdam Consensus criteria 84 (2003), requires two of the following: hyperandrogenism, oligo-or amenorrhea and polycystic 85ovaries. PCOS is the leading cause of anovulatory infertility in women, and women with PCOS 86also have an increased likelihood of miscarriage and pregnancy complications. Though ...

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Section: Resultsmentioning

confidence: 99%

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

Torres

Ho²,

Arroyo³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Another association between obesity and FGID is the gut microbiota. Increased risk of small intestinal bacterial overgrowth (28) and different gut microbiota composition (29) in obesity has been reported which might contribute to gastrointestinal dysmotility, excessive fermentation, altered visceral perception and gut permeability with their metabolites leading to pain-predominant FGID (30,31). Finally, obesity and FGID share common psychological comorbidities, such as stress, depression, and anxiety, which can contribute to each other's development and aggravate each other (32,33,34).…”

Section: Discussionmentioning

confidence: 99%

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Galai

Moran‐Lev

Cohen³

et al. 2020

Preprint

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Background Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders. Methods We conducted a retrospective study of children (2-18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016-10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85th percentile were designated as being overweight/obese. A population control group was obtained from the 2015-2016 Israel national health survey. Results Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventy-one children (41%) were classified as having functional abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese. Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Children with FAP and overweight were older [12.4 (range 9.8-15.3) vs. 10.8 (7.4-14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to Children with FAP and normal weight. Conclusions Adolescents with FAP had higher prevalence of overweight/obesity compared to controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.

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“…Up to the present moment, the specific intestinal microbiota profile of obese individuals has not been identified [3,4]. The diversity of the human intestinal microbiota in adults and newborns (aged 0 to 2 years) has been examined in detail in another study [37]; however, little is known about the gut microbiota composition in adolescents, [38] a problem that our study sought to address.…”

mentioning

confidence: 97%

Abundance of Gut Microbiota, Concentration of Short-Chain Fatty Acids, and Inflammatory Markers Associated with Elevated Body Fat, Overweight, and Obesity in Female Adolescents

Miranda

Amorim

Bastos

et al. 2019

Mediators of Inflammation

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Background and Aims. Overweight is ever more prevalent in the pediatric population, and this cardiometabolic factor can be associated with inflammatory markers, gut microbiota composition, and short-chain fatty acid (SCFA) concentrations. The aim of this study is to evaluate to what extent the abundance of gut microbiota phyla, SCFA concentrations, and inflammatory markers are associated with elevated body fat percentage (BF%), overweight, and obesity in female adolescents. Methods. An experimental and comparative study was conducted with 96 girls 14 to 19 years old. They were divided into 3 groups: G1—eutrophic (EUT) and adequate BF%; G2—EUT and high BF%; and G3—overweight (OW) or obese (OB) and high BF%. Waist circumference (WC), waist to height ratio (WtHR), and neck circumference (NC) were analyzed as indicators of central visceral adiposity. The BF% was evaluated by DEXA equipment. A food frequency questionnaire was used to evaluate the main types of food consumed in a week. The abundance of the Firmicutes, Bacteroidetes, and Proteobacteria phyla was measured by real-time polymerase chain reaction (RT-qPCR), and the SFCA concentrations (acetic, butyric, and propionic) were determined by high-performance liquid chromatography (HPLC). The inflammatory markers leptin, tumor necrosis factor-alpha, interleukin-6, and high-sensitivity C-reactive protein (hs-CRP) were assessed. Results. Female adolescents in groups G2 and G3 had greater central visceral adiposity and leptin concentration than those in group G1. No association was found between gut microbiota phyla abundance and SFCA concentrations in any of the groups. WC and frequency of consumption of oily and fatty foods were associated with Firmicutes abundance and SFCA concentrations. Girls with high WC also had the greatest leptin (p<0.001) and hs-CRP (p=0.035) concentrations. Conclusions. Inflammatory markers showed association with increased BMI and high BF% in female adolescents. The abundance of Firmicutes was associated with WC and NC, but not with BMI classification or BF%. Specifically, WC and the consumption of oils and fats showed correlation with SCFA concentrations. Different anthropometric indicators, such as NC and WC, should be incorporated into the clinical evaluation of the nutritional status of individuals in the adolescent population.

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Human Gut Microbiota Associated with Obesity in Chinese Children and Adolescents

Cited by 124 publications

References 43 publications

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Abundance of Gut Microbiota, Concentration of Short-Chain Fatty Acids, and Inflammatory Markers Associated with Elevated Body Fat, Overweight, and Obesity in Female Adolescents

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