Human gynecologic cancers heterotransplanted into athymic nude rats

Sawada, Masumi; Matsui, Yoshitaka; Hayakawa, Kenichi; Nishiura, H; Okudaira, Y; Taki, Ichiro

doi:10.1016/0090-8258(82)90030-0

Cited by 12 publications

(8 citation statements)

References 5 publications

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“…Their usefulness as models for screening of anti-tumor drugs has been appreciated. Several reports, including some by us, have described the establishment of human ovarian tumors in athymic nude mice (Kullander et al, 1978;Sawada et al, 1981Sawada et al, , 19821983Hamilton et al, 1984;Friedlander et al, 1985;Ward, et , 1987). Positive responses of human xenografted ovarian tumors to steroid hormones have not been reported.…”

mentioning

confidence: 99%

“…We therefore looked for an in vivo experimental system in order to examine hormone responsiveness of ovarian cancer. Since 1977, we have been using a human tumor transplantation system using nude mice to help determine the nature of the tumor and to screen anti-tumor drugs (Sawada et a[., 1981(Sawada et a[., , 1982(Sawada et a[., , 1983(Sawada et a[., , 1985(Sawada et a[., , 1986(Sawada et a[., , 1987. This present paper describes sex steroid-responsive growth of a newly-established line of ovarian tumors heterotransplanted into nude mice and designated OVA-5.…”

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confidence: 99%

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Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Sawada

Terada

Wada

et al. 1990

Intl Journal of Cancer

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A new line of human serous cystadenocarcinoma of the ovary, designated OVA-5, has been established in athymic nude mice. A strong correlation was noted between tumor volume and plasma CA125 levels in mice bearing OVA-5 tumor. Growth of the OVA-5 tumor in castrated male nude mice was accelerated by s.c. administration of estradiol-17 beta and 5 alpha-dihydrotestosterone but not by progesterone. Estradiol-17 beta and 5 alpha-dihydrotestosterone also accelerated the growth of the OVA-5 tumor heterotransplanted into sialoadenectomized castrated male nude mice. No remarkable change was observed in the histological appearances of the tumors between control groups and hormone-treated groups. Receptor assays revealed that the OVA-5 tumor had both estrogen and androgen receptors. Growth of the OVA-5-tumor is thus responsive to estrogen and androgen.

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confidence: 99%

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confidence: 99%

Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Sawada

Terada

Wada

et al. 1990

Intl Journal of Cancer

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“…In addition to the established in vitro cell lines shown in Table I, 2 xenograft yolk sac carcinoma lines, YSTl and YST2 (Sawada et al, 1982), were also studied by immunohistochemistry.…”

Section: Cell Linesmentioning

confidence: 99%

“…In addition, 2 xenografted yolk sac carcinoma lines YSTl and YST2 (Sawada et al, 1982) were examined using immunohistochemistry by Sawada and Hata. Neither expressed SSEA-3 or -4.…”

Section: Staining Patterns Of the Antibodies In Turnour Biopsiesmentioning

confidence: 99%

Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours

et al. 1996

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“…Con A LCH Ftg. 5. Serum SFP subfractions in a 26-year-old patient with yolk sac tumor of the ovary, specific differences of carbohydrate moiety were not discussed in the present study.…”

Section: Qv-s-25mentioning

confidence: 61%

Alpha‐Fetoprotein Subtractions in Germ Cell Tumors Identified by Con A or LCH Crossed‐Line Affinity Immunoelectrophoresis

Ishiguro

Sawada

Sakaguchi

et al. 1984

American Journal of Reproductive Immunology

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Using concanavalin A (Con A) crossed-line affinity immunoelectrophoresis and lentil lectin (LCH) crossed-line affinity immunoelectrophoresis, alpha-fetoprotein (AFP) subfractions were studied in sera including three sera from nude mice heterotransplanted with human yolk sac tumor of the ovary and three sera from patients with yolk sac tumor, mature solid teratoma, or immature solid teratoma of the ovary. In sera of nude mice bearing yolk sac tumor or from a patient with yolk sac tumor, subfractions from yolk sac and those from fetal liver were identified. Since AFP subfractions from yolk sac and fetal liver can be differentiated according to the carbohydrate moieties, our findings indicate that AFP produced by yolk sac tumor and fetal yolk sac are to some extent differently glycosylated. We also found that AFP produced by yolk sac tumor and fetal yolk sac are to some extent differently glycosylated. We also found that AFP in both mature and immature solid teratoma was composed of two subfractions ontogenetically originating from yolk sac or fetal liver. All these findings indicate that more than two different factors are responsible for the AFP synthesis in germ cell tumor of the ovary.

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Human gynecologic cancers heterotransplanted into athymic nude rats

Cited by 12 publications

References 5 publications

Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours

Alpha‐Fetoprotein Subtractions in Germ Cell Tumors Identified by Con A or LCH Crossed‐Line Affinity Immunoelectrophoresis

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