Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

Hirai, Takeru; Ikeda-Imafuku, Mayumi; Tasaka, Nanami; Chuang, Victor Tuan Giam; Xian, Ming; Ishida, Tatsuhiro; Akaike, Takaaki; Ishima, Yu

doi:10.1016/j.arres.2023.100091

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…The stratum corneum of hair is established through the progressive keratinization of keratinocytes. To investigate the process through which POFs repair UV-induced hair damage, keratinocytes were utilized as experimental models for further investigation [ 26 ]. To evaluate the potential cytotoxic effects of POFs on keratinocytes, MTT assays were performed at varying concentrations over a 24-h period to ascertain the optimal dosage of POFs for subsequent experimentation.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair

Xu,

Dai,

et al. 2024

Molecules

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Background: Androgenetic alopecia (AGA) causes thinning hair, but poor hair quality in balding areas and damage from UV radiation have been overlooked. Plant extracts like Platycladus orientalis flavonoids (POFs) may improve hair quality in AGA. This study examines POFs’ effectiveness in treating AGA-affected hair and repairing UV-induced damage. Methods: Hair samples were analyzed using scanning electron microscopy (SEM) to examine surface characteristics, electron paramagnetic resonance (EPR) spectroscopy to measure free radicals in the hair, and spectrophotometry to assess changes in hair properties. Results: POFs effectively removed hydroxyl radicals from keratinocytes and had antioxidant properties. They also reduced UV-induced damage to AGA hair by mitigating the production of melanin free radicals. Following POF treatment, the reduction in peroxidized lipid loss in AGA hair was notable at 59.72%, thereby effectively delaying the progression of hair color change. Moreover, protein loss decreased by 191.1 μ/g and tryptophan loss by 15.03%, ultimately enhancing hair’s tensile strength. Conclusion: compared to healthy hair, hair damaged by AGA shows more pronounced signs of damage when exposed to UV radiation. POFs help protect balding hair by reducing oxidative damage and slowing down melanin degradation.

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Section: Resultsmentioning

confidence: 99%

Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair

Xu,

Dai,

et al. 2024

Molecules

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“…The hair shaft is composed of mainly keratins, the intermediate filament proteins with high cysteine content responsible for the mechanical strength and the antioxidant capacity of hair fibre [2,3]. Extract of the keratins obtained from curly hair after UV irradiation demonstrated a visibly decreased peak at 210-220 nm in the spectral absorbance analysis compared to straight hair.…”

Section: Discussionmentioning

confidence: 99%

“…The main components of hair are keratins, members of the intermediate filament family of proteins that are distinguished by a relatively high cysteine content. The cysteine residues form intra-and inter-molecular disulfide bonds as well as polysulfide bonds that collectively contribute to the mechanical strength and antioxidant capacity of hair fibre [2,3]. There are seventeen subtypes of keratins identified, which can be distinguished based on the isoelectric points, molecular weight and specific localization within the compartments of the hair shaft.…”

Section: Introductionmentioning

confidence: 99%

“…There are seventeen subtypes of keratins identified, which can be distinguished based on the isoelectric points, molecular weight and specific localization within the compartments of the hair shaft. In addition to the disulfide bonds, a significant number of hydrogen bonds contribute to the cross-linking of the keratins and the structure of hair fibres [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Use of Natural Ingredients for Textured Hair UV Protection

Markiewicz,

Idowu

2024

Preprint

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Human hair is characterized by significant diversity, which is dictated by the individual genetic makeup. It is estimated that up to 70% of the world’s population has textured hair, with a signif-icant proportion also living in areas with high exposure to ultraviolet radiation (UVR). This highlights the unique requirements for textured hair care products that can protect hair shafts from the harmful effects of the environment whilst enhancing the natural features of the fibre. In this study, we investigated the UV-protective effects of hair conditioner formulated from active ingredients, mangiferin, ferulic acid and naringin. The analysis of UV-irradiated straight and textured hair was performed by measurements of hair thickness and darkness, the uptake of the fluorescent dye, spectral absorbance of keratin extracts, ATR-FTIR and SEM. We found that tex-tured hair was more sensitive to UVR-induced changes than straight hair, with the primary mo-lecular targets represented by chemical groups in keratins. Pre-treatment of the hair with condi-tioner had protective effects against structural damage and oxidative stress caused by UVR. These data indicate the importance of the personalized approach to hair research and the formu-lation of hair care products tailored to the individual demands of textured hair types.

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Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles

Zhang,

Guo,

Zhang

et al. 2024

Animals

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This study aimed to investigate the effects of dietary supplementation with methylsulfonylmethane (MSM) and myo-inositol (MI) on hair quality, fecal microbiota, and metabolome in poodles. Thirty-two adult poodles categorized based on initial body weight and sex were randomly assigned to four groups. These groups (designated the CON, MSM, MI, and MSM + MI groups) received a basal diet, the same diet supplemented with 0.2% MSM + 0% MI, the same diet supplemented with 0% MSM + 0.2% MI, or the same diet supplemented with 0.2% MSM + 0.2% MI, respectively. The study lasted for 65 days. During the entire study period, body weight, average daily weight gain, feed intake, energy intake, and fecal output were normal in all the animals and did not differ significantly among the treatment groups. Hair scale thickness was lower in the MI and MSM + MI groups than in the CON group on Day 65 (p < 0.05). An amino acid analysis of the hair revealed higher sulfur content in the MI and MSM + MI groups on Day 65 than on Day 0 (p < 0.05). Moreover, the poodles in the MSM, MI, and MSM + MI groups presented significantly lower levels of Proteobacteria_unclassified and Candidatus Phytoplasma than did those in the CON group. The relative abundance of Gammaproteobacteria_unclassified was greater in the MSM and MI groups than in the CON group (p < 0.05). The MSM group presented a greater abundance of Glucerabacter than the CON group (p < 0.05). Compared with those in the CON and MSM + MI groups, the abundances of Paramuribaculum and Hafnia in the MSM group were greater (p < 0.05). The abundances of Enterobacter and Kineothrix were greater (p < 0.05) in the MI group than in the CON and MSM + MI groups. The poodles in the MI group presented significantly greater abundances of Bacteroidales_unclassified, Halanaerobium, Mycobacterium, and Erysipelotrichaceae_unclassified than did poodles in the CON, MSM, and MSM + MI groups. Fecal metabolomics analysis revealed that MSM, MI, and MSM + MI treatment markedly affected carbohydrate metabolism. MSM + MI treatment also influenced lipid metabolism. These findings suggest that dietary supplementation with MSM and MI can improve the hair quality of poodles.

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Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

Cited by 4 publications

References 30 publications

Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair

Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair

Exploring the Use of Natural Ingredients for Textured Hair UV Protection

Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles

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