Human health risk assessment of heavy metals in major carp (Labeo rohita) of Mahananda river in Northern India

Kumar, Arbind; Kumar, Anil; Jha, Sasinath

doi:10.31783/elsr.2020.613449

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…The results showed that THQ values for individual metals as well as HI for combined metals were lower than 1 as a result of consuming the assumed portion of sea trout ( Table 4 ). The above observations were identical to those made by other authors [ 36 , 41 , 43 , 47 ]. The average THQ value for Hg was significantly higher than that for Pb and Cd, with a maximum of up to 0.582.…”

Section: Resultssupporting

confidence: 92%

“…The estimated tolerable daily intake (ETDI) of Pb and Cd studied by others [ 41 ] was also lower than the PTDI (provisional tolerable daily intake). The uptake of Pb and Cd from fish against the background of the total dietary exposure of Polish students accounted for 6.9–30% and 18–67% of PTWI (provisional tolerable weekly intake), respectively [ 42 ].…”

Section: Resultsmentioning

confidence: 90%

“…Other authors reported significantly higher Pb levels in rainbow trout muscles, which also resulted in a greater coverage of BMDL 10 (9.73%) and BMDL 01 (24.5%) [40]. The estimated tolerable daily intake (ETDI) of Pb and Cd studied by others [41] was also lower than the PTDI (provisional tolerable daily intake). The uptake of Pb and Cd from fish against the background of the total dietary exposure of Polish students accounted for 6.9-30% and 18-67% of PTWI (provisional tolerable weekly intake), respectively [42].…”

Section: Health Risk Assessment For Fish Consumptionmentioning

confidence: 95%

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Heavy Metals and the Occurrence of Ulcerative Dermal Necrosis (UDN) in Sea Trout from the RIVER REGA, Poland—Consumer Health Assessment

Rajkowska-Myśliwiec

Protasowicki

Tański

et al. 2022

IJERPH

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Various factors, including heavy metals, can make fish more susceptible to disease. This study investigated, inter alia, the relationship between Pb, Cd, and Hg contamination of the organs and muscles of sea trout from the river Rega (Poland) and the occurrence of UDN (ulcerative skin necrosis) symptoms. Moreover, the dietary risk of Pb, Cd, and Hg uptake from the muscles of healthy sea trout was assessed based on estimated daily intake (EDI), target hazard quotient (THQ), benchmark dose lower confidence limits (BMDL01 and BMDL10), and tolerable weekly intake (TWI). The metal concentrations varied, depending on the fish organs and the fish condition. A significantly higher amount of Pb was found in the gonads, gills, and muscles, Cd in the kidneys, and Hg in the muscles of sea trout with UDN symptoms. The lowest concentrations of Pb and Cd were detected in the muscles, and of Hg in the gonads. Dietary exposure to Pb, Cd, and Hg accounted for: 0.4% of BMDL01 and 1.0% of BMDL10, 0.56% of TWI, and 16.5% of TWI, respectively. THQs for each metal and the HI value for combined metals were below 1. The weakening of fish due to UDN-like disease probably increased the accumulation of Pb in the gonads, gills, and muscles, and of Cd in the kidneys, of the sea trout. As regards the maximum levels (MRLs), the muscles of healthy sea trout are safe for consumption. The risk assessment suggests no concern for the health of consumers.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 90%

Section: Health Risk Assessment For Fish Consumptionmentioning

confidence: 95%

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Heavy Metals and the Occurrence of Ulcerative Dermal Necrosis (UDN) in Sea Trout from the RIVER REGA, Poland—Consumer Health Assessment

Rajkowska-Myśliwiec

Protasowicki

Tański

et al. 2022

IJERPH

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“…Ahmed et al (2019) have reported bioaccumulation of Pb, Cr, and Cd exceeding the recommended limits in five estuarine fish species. Kumar et al (2020) also validated the presence of hazardous levels of Pb and Cd in L. rohita from Mahananda river, India. The MPI of our studied fish species was found to be ranging from 2.29 to 2.43 mg/kg.…”

Section: Discussionmentioning

confidence: 64%

Heavy metal contamination and potential health risk assessment associated with selected farmed fish in Rajshahi, Bangladesh

2023

JJBS

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The present investigation was conducted with a view to evaluating heavy metal contamination of four selected fish species (Labeo rohita, Catla catla, Cirrhinus cirrhosus, and Hypophthalmichthys molitrix) and the potential health risks of its consumers in Rajshahi, Bangladesh. Twenty-one feed samples and eighty-four fish specimens were collected from seven different farms scattered across the Rajshahi district and subsequent screening of heavy metal was conducted through atomic absorption spectrophotometer (AAS). The heavy metal concentration of Pb, Co, Cr, Cd and Ni was found beyond the permissible limits in fish feed and raw fish with a strong correlative association of heavy metals between them. Metal pollution index revealed that C. cirrhosus was the most polluted species while L. rohita was the least. Health risk assessment was conducted by evaluating estimated daily intake (EDI), health risk index (HRI), target hazard quotient (THQ), hazard index (HI) and target carcinogenic risk (TR). EDI of metal was higher in children, and according to HRI, they were at two to three times more risk compared to the adults. THQ of all the heavy metals across the selected species was found to be less than 1 demonstrating the absence of non-carcinogenic hazard for individual heavy metal intake. However, HI values indicated that the cumulative effect of those heavy metals might impart some degree of non-carcinogenic effect over lifelong exposure. TR values suggested that the carcinogenic effect of Pb remained negligible while Cr, Cd and Ni had low to moderate risk of developing cancer with a greater probability of its occurrence in women than men.

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“…The River Mahananda is a major river in North India and has a vital role in regulating the economy of the adjoining areas [ 22 ]. The river flows through the Himalayan mountains where it originates and descends into the plains in the sub-Himalayan region of Darjeeling district in West Bengal flowing through the Mahananda Wildlife Sanctuary.…”

Section: Methodsmentioning

confidence: 99%

Characterization of a hemolytic and antibiotic-resistant Pseudomonas aeruginosa strain S3 pathogenic to fish isolated from Mahananda River in India

Ghosh,

Mangar,

Choudhury

et al. 2024

PLoS ONE

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Virulent strain Pseudomonas aeruginosa isolated from Mahananda River exhibited the highest hemolytic activity and virulence factors and was pathogenic to fish as clinical signs of hemorrhagic spots, loss of scales, and fin erosions were found. S3 was cytotoxic to the human liver cell line (WRL-68) in the trypan blue dye exclusion assay. Genotype characterization using whole genome analysis showed that S3 was similar to P. aeruginosa PAO1. The draft genome sequence had an estimated length of 62,69,783 bp, a GC content of 66.3%, and contained 5916 coding sequences. Eight genes across the genome were predicted to be related to hemolysin action. Antibiotic resistance genes such as class C and class D beta-lactamases, fosA, APH, and catB were detected, along with the strong presence of multiple efflux system genes. This study shows that river water is contaminated by pathogenic P. aeruginosa harboring an array of virulence and antibiotic resistance genes which warrants periodic monitoring to prevent disease outbreaks.

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Human health risk assessment of heavy metals in major carp (Labeo rohita) of Mahananda river in Northern India

Cited by 4 publications

References 25 publications

Heavy Metals and the Occurrence of Ulcerative Dermal Necrosis (UDN) in Sea Trout from the RIVER REGA, Poland—Consumer Health Assessment

Heavy Metals and the Occurrence of Ulcerative Dermal Necrosis (UDN) in Sea Trout from the RIVER REGA, Poland—Consumer Health Assessment

Heavy metal contamination and potential health risk assessment associated with selected farmed fish in Rajshahi, Bangladesh

Characterization of a hemolytic and antibiotic-resistant Pseudomonas aeruginosa strain S3 pathogenic to fish isolated from Mahananda River in India

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