Human health risk assessment of pesticide residues in honeysuckle samples from different planting bases in China

Wu, Peiling; Wang, Pengsi; Gu, Mengying; Xue, Jiaying; Wu, Xiaoli

doi:10.1016/j.scitotenv.2020.142747

Cited by 56 publications

(34 citation statements)

References 39 publications

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“…Por otro lado, en un estudio en Kenia encontraron que la exposición directa de los agricultores a plaguicidas como el dimetoato, malatión, carbofurano, carbaril y heptacloro les produjo intoxicaciones y encontraron una asociación entre el no uso de equipos de protección, desconocimiento en el uso con las intoxicaciones (Marete et al, 2021); así mismo en una evaluación del riesgo mediante métodos de cociente de peligro, índice de peligro determinaron los riesgos para el ser humano a corto y largo plazo de la exposición de plaguicidas tales como clorpirifos, fipronil y carbofurano, demostrando que el mayor riesgo son las intoxicaciones de las personas adultas (Wu et al, 2021).…”

Section: Discussionunclassified

Riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas: Una revisión sistemática

Mendoza

2021

Pakamuros

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Los seres humanos están expuestos de forma directa e indirecta a diferentes tipos de plaguicidas procedentes de actividades agrícolas, estos plaguicidas por ser tóxicos para la salud humana afectando a los trabajadores agrícolas y residentes cercanos. En ese contexto el objetivo fue analizar el riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas. Se desarrolló mediante una revisión bibliográfica sistemática consultando la base de datos Scienciedirect desde enero a agosto del 2021. Se encontró qué el 52.63% de los artículos científicos estaban relacionados a diferentes tipos de cáncer, el 26.32% a intoxicaciones, el 15.79% a problemas y trastornos mentales y el 5.26% a alteraciones metabólicas y hematológicas, concluyendo que los plaguicidas utilizadas en actividades agrícolas generan en el ser humano un mayor riesgo a tener cáncer de tiroides, tumores, cáncer de pulmón, leucemia linfoblástica/mieloide y cáncer colorrectal, además un mayor riesgo a intoxicaciones por ingestión, inhalación y por vía cutánea siendo mortal muchas veces, también genera un mayor riesgo de retardo del crecimiento y desarrollo en los niños, cefalea intensa, párkinson, preciastrocitoma, meduloblastom y ependimoma, así mismo genera alteraciones del colesterol, hematocito, plaquetas y hemoglobina.

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Section: Discussionunclassified

Riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas: Una revisión sistemática

Mendoza

2021

Pakamuros

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“…Recently, researchers have paid more attention to systematic evaluation and risk analysis of several pesticides in Chinese herbs (Luo et al, 2021;. The hazard quotient (HQ) and hazard index (HI) methods have been applied to evaluate the potential health risk of CHMs in recent research (Wu et al, 2020). However, most of these studies refer to the food model without considering the consumption characteristics of CHMs.…”

Section: Introductionmentioning

confidence: 99%

Levels and Health Risk of Pesticide Residues in Chinese Herbal Medicines

et al. 2022

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In the present study, 168 pesticides in 1,017 samples of 10 Chinese herbal medicines (CHMs) were simultaneously determined by high-performance liquid (HPLC-MS/MS) and gas (GC-MS/MS) chromatography–tandem mass spectrometry. A total of 89.2% of the samples encompassed one or multiple pesticide residues, and the residue concentrations in 60.5% of samples were less than 0.02 mg kg−1, revealing the relatively low residue levels. The hazard quotient and hazard index methods were used to estimate the health risk for consumers. For a more accurate risk assessment, the exposure frequency and exposure duration of CHMs were involved into the exposure assessment, which was obtained from a questionnaire data of 20,917 volunteers. The results of chronic, acute, and cumulative risk assessment indicated that consumption of CHMs is unlikely to pose a health risk to consumers. Ranking the risk of detected pesticides revealed that phorate, BHC, triazophos, methidathion, terbufos, and omethoate posed the highest risk. Our results also showed that pollution of the aboveground medicinal part was more serious. Although exposure to pesticides in tested CHMs was below dangerous levels, more strict controlled management should be carried out for banned pesticides due to the high detection rate and illegal use in the actual planting practice.

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“…Regarding herbal medicines, however, equivalent MRLs are only specified for 33 pesticides (CP, 2020 version) [ 1 ]. Many studies monitoring pesticides have been conducted in China to assess the exposure risk of humans to pesticide residues in vegetables, fruits, and crops [ 18 ]. So far, there are only some reports on the establishment of detection methods or the determination of pesticide residues in CX, with low sample sizes and small production areas.…”

Section: Introductionmentioning

confidence: 99%

“…Anastassiades et al developed an all-purpose pretreatment method for multi-residue pesticide analysis in foodstuffs, named the QuEChERS method (quick, easy, cheap, effective, rugged, and safe) [ 19 ]. So far, the QuEChERS method has been modified and applied in the pretreatment of different environmental and food samples, as well as herbal medicines, such as Chuanxiong Rhizoma, honeysuckle, Corydalis Rhizoma, Angelicae sinensis radix [ 14 , 15 , 16 , 18 , 20 ]. Tandem mass spectrometry has become prevalent because of its high degree of assurance in identification and quantification in multi-residue pesticide analysis.…”

Section: Introductionmentioning

confidence: 99%

“…The Chinese Pharmacopoeia (CP, 2020 version) [ 1 ] and the list of prohibited and restricted pesticides from the Ministry of Agriculture of China were used as the evaluation standards. The present status of pesticide residues in CX in China was systematically studied, and the exposure and potential health risks of 37 pesticide residues detected in CX were calculated using the hazard factor (HQ) and hazard index (HI) methods [ 18 , 22 , 23 ], providing a reference for the quality and safety evaluation. Compared with previous studies, our samples represented more collection sites, a larger sample size, and had stronger representativeness.…”

Section: Introductionmentioning

confidence: 99%

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Detection and Risk Assessments of Multi-Pesticides in Traditional Chinese Medicine Chuanxiong Rhizoma by LC/MS-MS and GC/MS-MS

Zhang

Gou

et al. 2022

Molecules

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With the internationalization of traditional Chinese medicines (TCMs) and the increasing use of herbal medicines around the world, there are concerns over their safety. In recent years, there have been some sporadic reports of pesticide residues in Chuanxiong Rhizoma (CX), although the lack of systematic and comprehensive analyses of pesticide residues and evaluations of toxicological risks in human health has increased the uncertainty of the potential effects of pesticides exposure in humans. This study aimed to clarify the status of pesticide residues and to determine the health risks of pesticide residues in CX. The findings of this study revealed that 99 batches of CX samples contained pesticide residues ranging from 0.05 to 3013.17 μg/kg. Here, 6–22 kinds of pesticides were detected in each sample. Prometryn, carbendazim, dimethomorph, chlorpyrifos, chlorantraniliprole, pyraclostrobin, and paclobutrazol were the most frequently detected pesticides, with detection rates of 68.69–100%. Insecticides and fungicides accounted for 43.23% and 37.84% of the total pesticides detected, respectively. Here, 86.87% of the pesticide content levels were lower than 50 μg/kg, and a small number of samples contained carbofuran, dimethoate, and isofenphos-methyl exceeding the maximum residue levels (MRLs). A risk assessment based on the hazard quotient/hazard index (HQ/HI) approach revealed that the short-term, long-term, and cumulative risks of pesticide residues in CX are well below the levels that may pose a health risk. Worryingly, six banned pesticides (carbofuran, phorate sulfone, phorate-sulfoxide, isofenphos-methyl, terbufos-sulfone, and terbufoxon sulfoxide) were detected. This study has improved our understanding of the potential exposure risk of pesticide multi-residues in CX. The results of the study will have a positive impact on improving the quality and safety of CX and the development of MRLs for pesticide residues.

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Human health risk assessment of pesticide residues in honeysuckle samples from different planting bases in China

Cited by 56 publications

References 39 publications

Riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas: Una revisión sistemática

Riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas: Una revisión sistemática

Levels and Health Risk of Pesticide Residues in Chinese Herbal Medicines

Detection and Risk Assessments of Multi-Pesticides in Traditional Chinese Medicine Chuanxiong Rhizoma by LC/MS-MS and GC/MS-MS

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