Human herpes virus-8 serology and DNA analysis in recipients of renal allografts showing kaposi's sarcoma and their respective donors

Weigert, André; Pires, Alda F. A.; Adragão, Teresa; Cardoso, E A; Cardoso, Caroline de Souza; Sancho, Rocı́o; Trindade, Hermínio G.; Pimentel, Mark; Casqueiro, A; Machado, Daisy Maria

doi:10.1016/j.transproceed.2004.05.023

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…Twenty skin cancers occurred in nonwhite individuals in our cohort; KS was the most frequent, affecting 8/78 (14%) African/African-Caribbeans compared with 1% of white Europeans. Our data on African OTRs KS are similar to that previously reported in a Portuguese study in which 8/52 (15.4%) Africans developed KS compared with 3/364 (0.8%) white European patients in a cohort of 416 OTRs (50). It also accords with the endemic prevalence of human herpes virus-8 (HHV8) infection in countries of birth (51,52).…”

Section: Scale Of the Skin Cancer Burden In Otrs Is Considerable And supporting

confidence: 90%

A Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22-Year Prospective Study in an Ethnically Diverse Population

Harwood

Mesher

McGregor

et al. 2013

American Journal of Transplantation

139

146

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Skin cancer is a frequent complication of organ transplantation. Current guidelines advise specialist skin surveillance but there are limited data on how these should be implemented. This study determines overall burden of cancer and relevant intervals for strategic surveillance in an ethnically diverse transplant population. Prospective data on time to first and subsequent cancers and cumulative burden with respect to defined risk factors were analyzed in a cohort of 1010 patients in a UK center over 22 years. Among 931 individuals transplanted >6 months (mean 10.3 years), 1820 skin cancers occurred in 267 (29%) individuals and were multiple in 66%. Cumulative incidence at 5, 10, 20 and 30 years was 11%, 25%, 54% and 74%, with median time to second, third and fourth cancers of 24, 14.7 and 8.4 months, respectively. Tumors were overwhelmingly squamous and basal cell carcinomas (73% and 24%, respectively). Skin phototype, ultraviolet radiation exposure, age at transplant and duration of transplant were significant risk predictors and were used to construct clinically relevant surveillance intervals. This study provides a comprehensive, prospective analysis of skin cancer morbidity and risk in an ethnically diverse transplant population from which we derive an evidence-based skin cancer surveillance program.

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Section: Scale Of the Skin Cancer Burden In Otrs Is Considerable And supporting

confidence: 90%

A Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22-Year Prospective Study in an Ethnically Diverse Population

Harwood

Mesher

McGregor

et al. 2013

American Journal of Transplantation

139

146

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“…Determination of individual subtypes has been reported to be helpful as a means of molecular epidemiology . Some studies have demonstrated that in a specific geographical region, a particular subtype (C3) is associated with PT‐KS while another subtype (A4) was associated with AIDS‐related KS . Some subtypes (C1, C3, or A1) have been isolated from samples collected from healthy individuals .…”

Section: Resultsmentioning

confidence: 99%

“…Some studies have demonstrated that in a specific geographical region, a particular subtype (C3) is associated with PT‐KS while another subtype (A4) was associated with AIDS‐related KS . Some subtypes (C1, C3, or A1) have been isolated from samples collected from healthy individuals . In comparison with subtype C, subtypes A and B have been shown to be associated with extra‐dermal extension of KS .…”

Section: Resultsmentioning

confidence: 99%

Post renal transplantation Kaposi's sarcoma: a review of its epidemiology, pathogenesis, diagnosis, clinical aspects, and therapy

Hosseini-Moghaddam

Soleimanirahbar

Mazzulli

et al. 2012

Transplant Infectious Dis

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“…Decreased skin cancer after cessation of immunosuppression therapy has been reported [13]. Remission of Kaposi sarcoma was observed after the reduction of immunosuppression [14]. This patient_s age when he underwent renal transplant was 50 years, and the duration of immunosuppression was more than 20 years.…”

Section: Discussionmentioning

confidence: 78%

2-Deoxy-2-[F-18]Fluoro-d-Glucose Positron Emission Tomography Illustrates Two Visceral Tumors in a Post Kidney Transplant Patient with Multiple Cutaneous Malignancies

et al. 2006

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The success of renal transplantation brings with it the dilemma of managing patients with complications from lifelong immunosuppressive therapy. Immunosuppressed transplant recipients are a special population with significantly increased risk for development of skin cancers. Because malignant tumors are increasing as demonstrated on 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) image, we report the unusual coincidence of multiple cutaneous cancers and two visceral malignancies 20 years after renal transplantation. The malignancies include basal cell and squamous cell carcinomas and malignant fibrous histiocytoma. FDG-PET images show, in this case, visceral masses with increased metabolism: one in the left upper lung and one in the abdomen, corresponding to individual mass lesions observed on computed tomography (CT) images of the chest and abdomen. A fine-needle biopsy of the nodule of the left upper lung lobe yielded a diagnosis of a sarcoma. The mass lesion of the abdomen had caused bowel obstruction, requiring exploratory laparotomy; histopathological findings from the resected mass from the abdomen confirmed the diagnosis malignant fibrous histiocytoma. This long-term immune suppressed transplant recipient developed viscerally located malignant lesions demonstrated by FDG-PET imaging and three types of cutaneous malignancies (skin cancers).

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Human herpes virus-8 serology and DNA analysis in recipients of renal allografts showing kaposi's sarcoma and their respective donors

Cited by 8 publications

References 14 publications

A Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22-Year Prospective Study in an Ethnically Diverse Population

A Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22-Year Prospective Study in an Ethnically Diverse Population

Post renal transplantation Kaposi's sarcoma: a review of its epidemiology, pathogenesis, diagnosis, clinical aspects, and therapy

2-Deoxy-2-[F-18]Fluoro-d-Glucose Positron Emission Tomography Illustrates Two Visceral Tumors in a Post Kidney Transplant Patient with Multiple Cutaneous Malignancies

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