Human Herpesvirus 1 in Wild Marmosets, Brazil, 2008

Longa, Camila S.; Bruno, Sávio Freire; Pires, Amaury R.; Romijn, Phyllis Catharina; Kimura, Leda S.; Costa, Carlos H. C.

doi:10.3201/eid1707.100333

Cited by 25 publications

(24 citation statements)

References 6 publications

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“…Based on the epidemiology of the cases in this study, it was verified that Neotropical primates are highly susceptible to HHV-1 (Melendez et al 1969, Murphy et al 1972, Bruno et al 1997, Juan-Sallés et al 1997, Huemer et al 2002, Matz--Rensing et al 2003, Schrenzel et al 2003, Hatt et al 2004, Lefaux et al 2004, Gozalo et al 2008, Longa et al 2011. This virus causes an acute and fatal disease in marmosets, characterized by multiple skin vesicles and ulcers as well as severe necrotizing meningoencephalitis (Juan-Sallés et al 1997, Hatt et al 2004, Lefaux et al 2004, Longa et al 2011.…”

Section: Discussionmentioning

confidence: 55%

“…This virus causes an acute and fatal disease in marmosets, characterized by multiple skin vesicles and ulcers as well as severe necrotizing meningoencephalitis (Juan-Sallés et al 1997, Hatt et al 2004, Lefaux et al 2004, Longa et al 2011.…”

Section: Discussionmentioning

confidence: 99%

“…In Brazil, few cases of HHV-1 infection in marmosets have been reported (Bruno et al 1997, Longa et al 2011. In this paper, we describe the clinical signs and gross and histopathological lesions of twelve captive marmosets (Callithrix jacchus and C. penicillata) spontaneously infected by HHV-1.…”

Section: Introductionmentioning

confidence: 91%

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Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

et al. 2014

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RESUMO.-[Infecção fatal por Herpesvirus simplex Tipo 1 (HHV-1) em saguis de cativeiro (Callithrix jacchus and Callithrix penicillata) no Brasil: caracterização clínica e patológica.] Infecção fatal por Herpesvirus simplex Tipo 1 (HHV-1) foi diagnosticada em 12 saguis de cativeiro (Callithrix jacchus e Callithrix penicillata) provenientes da região metropolitana de São Paulo, Estado de São Paulo. Os sinais clínicos foram variáveis entres os casos, no entanto, a maioria dos saguis afetados apresentavam sinais associados à replicação viral em epitélios: úlceras na cavidade oral, lín-gua e pele da face e hipersalivação; e no sistema nervoso central: prostração, convulsão e comportamento agressivo. Histologicamente, o principal achado foi meningoencefalite necrosante não supurativa difusa, leve a acentuada com gliose, vasculite e necrose neuronal. Inclusões intranucleares também foram observadas em encéfalo, cavidade oral, pele, glândula adrenal e plexo mioentérico. A imuno-histoquímica anti-HHV-1 confirmou a presença do antígeno viral em associação às lesões em encéfalo, mucosa oral e lingual, pele da face, glândula adrenal e plexo mioentéri-co. Em 7/8 saguis infectados foi detectada a presença de HHV-1 por reação em cadeia da polimerase (PCR) a partir de amostras de encéfalo. Conclui-se que HHV-1 causa uma infecção disseminada e fatal em saguis. Clinical signs were variable among the cases, but most affected marmosets presented signs associated with viral epithelial replication: oral, lingual and facial skin ulcers and hypersalivation, and viral replication in the central nervous system: prostration, seizure and aggressive behavior. Consistent microscopic findings were diffuse mild to severe nonsuppurative necrotizing meningoencephalitis with gliosis, vasculitis and neuronal necrosis. Additionally, in the brain, oral cavity, skin, adrenal gland and myoenteric plexus intranuclear inclusion bodies were present. Immunohistochemistry confirmed the presence of the HHV-1 antigen in association with lesions in the brain, oral and lingual mucosa, facial skin, adrenal gland and myoenteric plexus. HHV-1-specific polymerase chain reaction (PCR) analysis of the brain was carried out and the virus was detected in 7/8 infected marmosets. It is concluded that HHV-1 causes widespread fatal infection in marmosets.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

et al. 2014

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“…Although HSV-1 and HSV-2 infection of humans is mostly asymptomatic or associated with mild symptoms, these viruses can induce a lethal disease in certain NHPs, including marmosets (Callithrix jacchus) Hatt et al, 2004;Imura et al, 2014;Longa et al, 2011;Mätz-Rensing et al, 2003). Conversely, transmission of BV from macaques to humans via bites, scratches or exposure to contaminated urine and feces can cause encephalitis (Elmore and Eberle, 2008;Hilliard, 2007;Huff and Barry, 2003).…”

Section: Introductionmentioning

confidence: 99%

Detection systems for antibody responses against herpes B virus

et al. 2017

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Abstract. Herpes B virus (BV) infection is highly prevalent among adult Asian macaques and rarely causes severe disease in infected animals. In contrast, BV infection of humans can induce fatal encephalitis in the absence of treatment. Therefore, the development of diagnostic tests for specific and sensitive detection of antibodies against BV is an important task. The cross-reactivity of antibodies against BV with related simplex viruses of other primates may afford an opportunity to obtain sensitive detection systems without the need to work with the highly pathogenic BV. Moreover, it has been proposed that use of recombinant viral glycoproteins may allow for a detection of antibody responses against BV with high specificity. However, limited data are available for both approaches to BV diagnostic. Here, we report that simian agent 8 (SA8; infects African green monkeys)-and herpesvirus papio 2 (HVP-2; infects baboons)-infected cells allow for a more sensitive detection of antibody responses against BV in macaques than lysates of herpes simplex virus type 1 and 2 (HSV-1/2; infect humans)-infected cells and a commercial HSV ELISA (Enzygnost ® Anti-HSV/IgG). In addition, we show that sera from BV-infected macaques frequently contain antibodies against the recombinant BV glycoprotein gD (BV gD) that has been previously proposed as a diagnostic target for discriminating BV-and HSV-induced antibodies. However, we found that antibodies of some HSV-infected human patients also reacted with BV gD. In contrast, only sera of HSV-1-and HSV-2-infected humans, but not sera from BV-infected macaques, reacted with HSV-1/2 gG. Collectively, these results suggest that both SA8 and HVP-2 allow for sensitive and comparable detection of BVdirected antibody responses in macaques and that the combination of BV gD and HSV-1/2 gG needs to be complemented by a least one additional viral glycoprotein for reliable discrimination between antibody responses against BV and HSV-1/2 in humans.

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“…The death of introduced marmosets 556 (Callithrix spp.) infected with human herpesvirus 1 in a Brazilian nature reserve illustrates how 557 proximity to humans can risk the survival of wild primate populations (Longa et al, 2011). The 558 risk of epizootic disease transmission is particularly serious for those primates living near or 559 within regions inhabited by dense human populations, such as in most of Indonesia, where 560 Streptococcus equi caused high mortality among long-tailed macaques in 1994 (Soedarmanto et 561 al., 1996).…”

mentioning

confidence: 99%

Peer Review #2 of "Primates in peril: the significance of Brazil, Madagascar, Indonesia and the Democratic Republic of the Congo for global primate conservation (v0.1)"

2018

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Human Herpesvirus 1 in Wild Marmosets, Brazil, 2008

Cited by 25 publications

References 6 publications

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Detection systems for antibody responses against herpes B virus

Peer Review #2 of "Primates in peril: the significance of Brazil, Madagascar, Indonesia and the Democratic Republic of the Congo for global primate conservation (v0.1)"

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Human Herpesvirus 1 in Wild Marmosets, Brazil, 2008

Cited by 25 publications

References 6 publications

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Detection systems for antibody responses against herpes&#160;B virus

Peer Review #2 of "Primates in peril: the significance of Brazil, Madagascar, Indonesia and the Democratic Republic of the Congo for global primate conservation (v0.1)"

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Detection systems for antibody responses against herpes B virus