Human Herpesvirus 6 in Serum and Spinal Fluid of Patients With Multiple Sclerosis?—Reply

Álvarez‐Lafuente, Roberto; Heras, Virginia de las; Arroyo, Rafael

doi:10.1001/archneur.60.4.639-a

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…have not (148,(155)(156)(157)(158). One group reported detecting cell-free HHV-6A/B DNA in about 20% of CSF from patients with MS (159), but other groups have not (160,161).…”

Section: Viral Dna Rna and Antigens In Plaques And Csfmentioning

confidence: 99%

“…Viral load in the blood. Several groups have found cell-free viral DNA in serum more frequently in patients with MS than in healthy controls, predominantly HHV-6A (152,(163)(164)(165)(166)(167)(168)(169); others have not been able to confirm this finding (155)(156)(157)170). For example, one study found cell-free DNA in 60.2% of 78 patients with either relapsingremitting MS (RRMS) or secondary progressive MS (SPMS) compared to 14.6% of 123 healthy control subjects (169).…”

Section: Viral Dna Rna and Antigens In Plaques And Csfmentioning

confidence: 99%

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Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation

2020

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SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B), collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans from an early age. Although most people infected with these viruses appear to suffer no ill effects, the viruses are a well-established cause of encephalitis in immunocompromised patients. In this review, we summarize the evidence that the viruses may also be one trigger for febrile seizures (including febrile status epilepticus) in immunocompetent infants and children, mesial temporal lobe epilepsy, multiple sclerosis (MS), and, possibly, Alzheimer’s disease. We propose criteria for linking ubiquitous infectious agents capable of producing lifelong infection to any neurologic disease, and then we examine to what extent these criteria have been met for these viruses and these diseases.

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“…have not (148,(155)(156)(157)(158). One group reported detecting cell-free HHV-6A/B DNA in about 20% of CSF from patients with MS (159), but other groups have not (160,161).…”

Section: Viral Dna Rna and Antigens In Plaques And Csfmentioning

confidence: 99%

Section: Viral Dna Rna and Antigens In Plaques And Csfmentioning

confidence: 99%

Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation

2020

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Human herpesvirus 6 infection of the central nervous system

Caserta

2004

Curr Infect Dis Rep

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Human herpesvirus (HHV) 6 infects all children, usually during the first year of life. High fever is the hallmark of primary infection, with febrile seizures the most common complication. After primary infection, HHV-6 remains latent or persistent at multiple sites, with intermittent reactivation. Many disorders of the central nervous system (CNS) have been linked to HHV-6 reactivation, including chronic seizure disorders, encephalitis, and demyelinating disorders including multiple sclerosis. Although multiple studies have pieced together an understanding of the molecular organization, viral characteristics, immunology, and epidemiology of HHV-6, the true role of this virus in diseases of the CNS is still unfolding.

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