Human herpesvirus 8 (HHV‐8) infection in healthy urban employees from Greece: Seroprevalence and associated factors

Sypsa, Vana; Petrodaskalaki, Maria; Kalapothaki, V.; Whitby, Denise; Hatzakis, Angelos

doi:10.1002/jmv.20812

Cited by 22 publications

(18 citation statements)

References 40 publications

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“…Subjects aged 20–50 and > 50 had 63.3% and 144.5% higher risk for KSHV than those aged < 20 ( P = 0.009 and < 0.001, respectively). These results are consistent with those of several other studies, which described an increase of seroprevalence of KSHV with age in different populations [Baillargeon et al, 2001; Sitas et al, 1999; Sitas et al, 2001; Stein et al, 2004; Zavitsanou et al, 2007]. …”

Section: Discussionsupporting

confidence: 93%

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus and risk factors in Xinjiang, China

Sun

et al. 2009

Journal of Medical Virology

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Xinjiang, China is an endemic area for Kaposi's sarcoma (KS) but the seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) and risk factors remain undefined. In this study, antibodies to one KSHV latent protein (ORF73) and two KSHV lytic proteins (ORF65 and ORF-K8.1) were examined in 2,228 subjects from the general population and 37 subjects infected with HIV-1 in Xinjiang, and 560 subjects from the general population in Hubei, a low KS incidence region. The serostatus of a serum sample was defined based on positive results in any one of the three serologic assays. The seroprevalence of KSHV in the general population was higher in Xinjiang than in Hubei (19.2% vs 9.5%; odds ratios [OR], 2.28; 95% confidence interval [CI], 1.68-3.08; P < 0.001). Among the ethnic groups in Xinjiang, 68 (15.8%) Han, 182 (20.7%) Uygur, 140 (19.9%) Hazakh, 9 (33.3%) Xibo, and 29 (16.8%) Hui were KSHV-seropositive, respectively. Compared to the Han, the latter groups had an increase in the risk of KSHV of 62.2%, 63.8%, 180.1% and 30.2% (P = 0.003, 0.004, 0.018, and 0.286, respectively). Subjects aged < 20, 20-50, and > 50 had a seroprevalence of KSHV of 11.8%, 17.9% and 24.6%, respectively. Compared to subjects aged < 20, the latter groups had an increase in the risk of KSHV of 63.3% and 144.5% (P = 0.009 and < 0.001, respectively). Subjects infected with HIV-1 in Xinjiang had a seroprevalence of KSHV of 43.2%, and a 220% increase in the risk of KSHV compared to the general population (P < 0.001). Similar results were obtained when the seroprevalence of KSHV was analyzed with any single or two of the three serologic assays alone. Genotyping identified 3 unique sequences clustered in the A clade. This study indicates that Xinjiang has a high seroprevalence of KSHV. Geographic location, ethnicity, age and HIV-1 infection are risk factors. Serologic and genotyping results suggest the introduction of KSHV into Xinjiang by specific ethnic groups.

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Section: Discussionsupporting

confidence: 93%

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus and risk factors in Xinjiang, China

Sun

et al. 2009

Journal of Medical Virology

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“…All the above mentioned data triggered the study of the seroprevalence of HHV-8 in healthy blood donors in Greece. It has been previously reported that the prevalence of HHV-8 in the general population in Greece is 7.6% and that the seropositivity for HHV-8 was associated with a history of endoscopic procedures and HBsAg positivity [8]. Nevertheless, we found no blood donor tested positive for HHV-8 IgG antibodies.…”

Section: Discussioncontrasting

confidence: 56%

Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

Politou

Koutras

Kaparos

et al. 2014

Virol J

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BackgroundHerpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in endemic and not endemic areas. HHV-6 and HHV-8 seroprevalence and viral load among blood donors have been reported from different countries. The aim of our study was to assess the seroprevalence of HHV-8 and HHV-6 in volunteer blood donors from Greece which is unknown.FindingsSerum samples from 179 healthy blood donors were tested for the presence of IgG antibodies against HHV-6 and HHV-8 with ELISA. None of the 179 donors of Greek origin tested was positive for HHV-8. HHV-6 seropositivity was assessed in 160 blood donors’ samples and was found to be 78.75% (126/160). The HHV-6 seroprevalence did not differ either between males and females or among different decade age groups.ConclusionsThe fact, that no blood donor was positive for HHV-8 IgG antibodies indicates that the risk for transfusion related HHV-8 transmission in Greece, if any, is negligible and does not warrant broad testing for HHV-8. Definitely further studies are needed, in order to clarify the potential risk of HHV-6 transmission.

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“…Further analysis of the risk factors associated with KSHV indicated that KSHV infection was associated with advancing age, low education level, and stationary population status. These results are consistent with those of several other studies, which described an increase in seroprevalence of KSHV with age in different populations (Baillargeon et al, 2001;Zavitsanou et al, 2007;. This correlation may be related to the natural aging process, and hypoimmunity may be a promoting agent for KSHV infection.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China

et al. 2017

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Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.

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Human herpesvirus 8 (HHV‐8) infection in healthy urban employees from Greece: Seroprevalence and associated factors

Cited by 22 publications

References 40 publications

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus and risk factors in Xinjiang, China

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus and risk factors in Xinjiang, China

Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China

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