Human Herpesvirus 8 Infection Among Adolescents in the REACH Cohort

Casper, Corey; Meier, Amalia; Wald, Anna; Morrow, Rhoda Ashley; Corey, Lawrence; Moscicki, Anna Barbara

doi:10.1001/archpedi.160.9.937

Cited by 16 publications

(18 citation statements)

References 46 publications

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“…2 Since the virus was more prevalent in sexually active men, its sexual mode of transmission was hypothesized. 3,4 However, it has also been reported that HHV-8 can be transmitted through nonsexual routes. 5 In addition, familial clustering of HHV-8 has been observed in highly endemic regions.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males

Munawwar

Sharma

Gupta

et al. 2014

AIDS Research and Human Retroviruses

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In India Kaposi's sarcoma is rarely seen in AIDS patients. Hence the current belief is that the incidence of human herpesvirus-8 (HHV-8) is very low in this subcontinent, most probably due to the heterosexual route of HIV transmission. However, there is a scarcity of data on the prevalence of HHV-8 in India. In India the primary mode of HIV transmission is the heterosexual route. Therefore we aimed to determine the prevalence of antibodies against HHV-8 in North Indian HIV-infected men naive of antiretroviral therapy (ART). In a prospective study, 165 Indian adult males were recruited from an ART clinic. Blood samples were collected before administering any antiretroviral drug. The sera were tested for antibodies against HHV-8 using a commercial enzyme-linked immunosorbent assay (ELISA) kit, which detects IgG antibodies to lytic antigens of HHV-8. All positive samples were confirmed for the presence of anti-HHV-8 antibodies using an indirect immunofluorescence assay (IFA). The IFA kit is intended to detect primary, latent, persistent, or reactivated infection of HHV-8. Of the 165 males, 43 (26.06%) were positive by ELISA while 26 (15.8%) were also positive by IFA. Seroprevalence decreased with increasing age ( p < 0.05). Factors independently associated with HHV-8 infection were younger age group and alcohol consumption. These findings suggest that even in a heterosexual population, HHV-8 can be transmitted frequently.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males

Munawwar

Sharma

Gupta

et al. 2014

AIDS Research and Human Retroviruses

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“…2 KS in HIV-negative MSM is rare despite seroprevalence studies showing that 15-30% have the causative virus, human herpes virus 8 (HHV-8). 3,4 There are a number of cases of HIV-negative men presenting with genital lesions of KS, but only a small portion of these report homosexual activity and none have been reported to have been treated with imiquimod. We describe the case of an HIV-negative homosexual man presenting with KS lesions located on the penis that responded rapidly to treatment with topical imiquimod 5% cream.…”

Section: Introductionmentioning

confidence: 99%

Topical imiquimod 5% as a treatment for localized genital Kaposi's sarcoma in an HIV-negative man: a case report

et al. 2012

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We report a case of Kaposi's sarcoma (KS) in an HIV-negative man who has sex with men (MSM) that was successfully treated by topical application of imiquimod 5% cream (Aldara). Our case highlights a potentially effective and non-invasive method of treatment of Kaposi's sarcoma in the shortest timeframe yet recorded. The location of the lesions on the patient's penis also highlights the need for a non-invasive treatment.

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“…The Reaching for Excellence in Adolescent Care and Health (REACH) study evaluated youth ages 13-18 years who were at high risk for HIV or were already infected with HIV. The study demonstrated that 11.2% of enrolled youth were HHV-8 antibody positive with no statistically significant difference between those with and without HIV infection [10]. These studies demonstrate a higher than expected seroprevalence for children in select populations living in the United States.…”

mentioning

confidence: 67%

A Review of Human Herpesvirus 8, the Kaposi's Sarcoma-Associated Herpesvirus, in the Pediatric Population

Dow

Cunningham

Buchanan

2013

Journal of the Pediatric Infectious Diseases Society

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Human Herpesvirus 8 Infection Among Adolescents in the REACH Cohort

Abstract: Human herpesvirus 8 is common among US adolescents practicing high-risk sexual behaviors. Sexual identity, race, and sexual behavior may influence the risk of infection with HHV-8 in women.

Cited by 16 publications

References 46 publications

Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males

Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males

Topical imiquimod 5% as a treatment for localized genital Kaposi's sarcoma in an HIV-negative man: a case report

A Review of Human Herpesvirus 8, the Kaposi's Sarcoma-Associated Herpesvirus, in the Pediatric Population

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