Human Herpesvirus 8 seroprevalence among blood donors in Mali

Malonga, Gervillien Arnold; Dienta, Sidi; Traoré, Fatoumata Tata; Maiga, Zalihatou; Ba, Alhassane; Faye, Ousmane; Chicaud, Elodie; Marot, Stéphane; Cálvez, Vincent; Marcelin, Anne‐Geneviève; Jary, Aude; Maïga, Almoustapha Issiaka

doi:10.1002/jmv.27850

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…This male superiority, is explained by the many contraindications to blood donation in women (breastfeeding, pregnancy and menstruation). This is in line with several studies carried out at the CNTS [21][22][23][24].…”

Section: Discussionsupporting

confidence: 92%

Gene expression profiling of p53 and c-myc in HTLV-1 positive blood donors in Congo

Iloukou,

Boumba,

Pouki

et al. 2024

Problems of Virology

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Objectives. The HTLV-1 infection persists for life, remaining as asymptomatic viral reservoirs in most patients, ensuring the chain of transmission, but around 4% develop adult T-cell leukemia/lymphoma (ATLL). HTLV-1 is an oncogenic retrovirus that transforms CD4+ T lymphocytes and deregulates the lymphoproliferative pathways that contribute to the development of ATLL. To achieve cell transformation, most oncogenic retroviruses use proto-oncogene capture transduction, with proviral integration disrupting the expression of tumor suppressors or proto-oncogenes. The aim. We conducted this study on the prevalence of HTLV-1 infection in blood donors to expand the HTLV-1 database, assess the risk of transmission via blood products, as well as evaluate the risk of persistent infection or development of neoplastic diseases in HTLV-1 carriers. Materials and methods. This is a cross-sectional study of blood donors of all categories. For this study, 265 blood donors were recruited at the Centre National de Transfusion Sanguine in Brazzaville. After testing for HTLV-1 antibodies by ELISA, proviral DNA was extracted from all ELISA-positive samples for detection by nested PCR, followed by RT qPCR using specific primers p53 and c-myc for gene expression. Results. 20/265 were positive for anti-HTLV-1 antibody, 5 donors were positive for proviral DNA. The prevalence of HTLV-1 was 1.8%. All HTLV-1-positive donors were male (1.8%), with a positive correlation (p = 0.05); the 1.1% of positive donors were regular, with the majority aged between 31 and 45 years (1.5%), and concubine donors were the most frequent (1.1%). All samples showed normal expression of the p53 and c-myc genes. Conclusion. The prevalence, though low, remains a serious problem. No abnormal p53 or c-myc gene expression was detected in HTLV-1-positive donors, which could mean that none of the T lymphocytes in these donors had been transformed by HTLV-1.

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Section: Discussionsupporting

confidence: 92%

Gene expression profiling of p53 and c-myc in HTLV-1 positive blood donors in Congo

Iloukou,

Boumba,

Pouki

et al. 2024

Problems of Virology

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Association between human herpesvirus 8 and lipid profile in northwest China: A cross‐sectional study

Zhang,

Wang,

et al. 2024

Journal of Medical Virology

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Human herpesvirus 8 (HHV‐8) infection shows obvious regional and ethnic differences. Although studies have shown that these differences may be associated with lipid metabolism, to date, no large‐scale studies have explored this. This study explored the seropositivity rate of HHV‐8 among 2516 residents from 10 regions of northwest China and then the correlates of HHV‐8 infection with lipid profile. The HHV‐8 serological positivity rate was 15.6% among all residents. The HHV‐8 seroprevalence ranged 11.2–27.6% among different ethnicities. Across different BMI levels, the positive rates of HHV‐8 were 27.6%, 16.9%, and 13.6% for a BMI < 18.5, 18.5–24.9, and ≥25, respectively. HHV‐8 seropositivity rate was lower for hypertensive people (12.6%) than for non‐hypertensive people (16.7%). Univariate logistic regression analyses revealed that age, hypertension, systolic blood pressure, BMI, total cholesterol, and high‐density lipoprotein cholesterol (HDL‐C) significantly correlated with HHV‐8 seropositivity (p < 0.05). Multivariate logistic regression analysis after adjusting for confounding factors showed that HDL‐C (odds ratio [OR]: 0.132, 95% confidence interval [CI], 0.082–0.212; p < 0.001) and BMI (OR: 0.959, 95% CI 0.933–0.986; p = 0.003) were associated with HHV‐8 seropositivity. Subgroup analyses concerning ethnicity, sex, or age demonstrated a consistent relationship with HDL‐C. The results of HHV‐8 seropositivity and BMI were inconsistent in the subgroups. However, Spearman's correlation analysis between HHV‐8 serum antibody titer and HDL‐C levels showed no linear relationship among HHV‐8 seropositive individuals (ρ = −0.080, p = 0.058). HHV‐8 serum antibody titers were also not significantly correlated with BMI (ρ = −0.015, p = 0.381). Low HDL‐C levels may be an independent risk factor for HHV‐8 infection, but there is no significant correlation between HDL‐C levels and HHV‐8 antibody titers.

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Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar

Zedan,

Elkhider,

Hicazi

et al. 2024

Journal of Infection and Public Health

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Human Herpesvirus 8 seroprevalence among blood donors in Mali

Cited by 4 publications

References 10 publications

Gene expression profiling of <i>p53</i> and <i>c-myc</i> in HTLV-1 positive blood donors in Congo

Gene expression profiling of <i>p53</i> and <i>c-myc</i> in HTLV-1 positive blood donors in Congo

Association between human herpesvirus 8 and lipid profile in northwest China: A cross‐sectional study

Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar

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