Human herpesvirus-8-unrelated primary effusion lymphoma of the elderly not associated with an increased serum lactate dehydrogenase level: A benign sub-group of effusion lymphoma without chemotherapy

Abstract

Human herpesvirus-8-unrelated primary effusion lymphoma characterized by lymphomatous effusion without nodal lesions occasionally exhibits spontaneous remission. To elucidate the factors associated with a good prognosis, this study analyzed the clinical parameters of four patients treated in the department and 109 patients reported in case reports. The median age was 71 years and the median overall survival was 20 months. Patients possessing two independent favorable factors, an elderly status (≥ 70 years) and low serum lactate dehydrogenase (< 500 IU/L) showed a markedly higher 1-year survival than patients lacking either of the two factors in the absence of chemotherapy (94% vs 20%, p = 3 × 10(-5)), which was similarly observed in the chemotherapy group (94% vs 51%, p = 0.002). The use of rituximab was also a strong predictor of survival (89% vs 49%, p = 7 × 10(-6)). Elderly patients not exhibiting an increased lactate dehydrogenase may represent a benign sub-group of effusion lymphoma, which do not require chemotherapy to achieve remission.

Aggressive genomic features in clinically indolent primary HHV8-negative effusion-based lymphoma

“…Thus far, a limited number of HHV8-negative EBL cases have been reported. [2][3][4][5] In these documented cases, treatment varied from drainage alone to chemotherapy and stem cell transplantation, with remarkable good outcome in those treated with drainage only. This underpins the importance of distinguishing HHV8-negative EBL from secondary effusion of DLBCL, which has a poor prognosis and requires an essentially different therapeutic approach.…”

“…This underpins the importance of distinguishing HHV8-negative EBL from secondary effusion of DLBCL, which has a poor prognosis and requires an essentially different therapeutic approach. 6 Genomic data of a limited number of HHV8-negative EBL have been reported that do not show a consistent or characteristic pattern, [2][3][4][5] precluding conclusions on their role in oncogenesis. In this study, we aimed to delineate the genomic landscape of HHV8-negative EBL using established next-generation sequencing procedures.…”

“…These findings are in line with classical karyotyping and comparative genomic analysis in the reported HHV8-negative EBL cases. [2][3][4][5] The copy number landscape of HHV8-negative EBL showed a remarkable enrichment of focal CNAs. Specifically, focal deletions at 3p14.2 and 6q21 were present in 6/8 cases (supplemental Figure 2; supplemental Table 3).…”

Human herpesvirus 8‑negative effusion‑based lymphoma with indolent clinical behavior in an elderly patient: A case report and literature review

“…HHV8-negative effusion-based lymphoma exhibits a less aggressive clinical course compared with PEL (17). Zaimoku et al (17) reported a markedly higher survival rate in patients with HHV8-negative effusion-based lymphoma (1-year survival rate, 60.1%) compared with those with PEL (1-year survival rate, 39.3%). Notably, the present case demonstrated no progression of disease over 1 year without chemotherapy.…”

HO-1/EBP interaction alleviates cholesterol-induced hypoxia through the activation of the AKT and Nrf2/mTOR pathways and inhibition of carbohydrate metabolism in cardiomyocytes

“…We suggest that cholesterol may destroy the balance of the TCA cycle and induce the excessive accumulation of Acyl-CoA by downregulation of Aco2 expression and upregulation of MDH2 and PDHE-1β expression. Otherwise, LDH catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis (46). The expression level of LDH was significantly decreased in the H9c2 cells treated with cholesterol.…”