Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma

Huang, Youqin; Li, J.J.; Zhang, W.C.; Feiner, D; Friedman‐Kien, Alvin E.; Kaplan, Mark H.; Poiesz, Bernard J.; Katabira, Ke

doi:10.1016/s0140-6736(95)90641-x

Cited by 413 publications

(220 citation statements)

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“…HHV-8 is present in all Kaposi's sarcoma lesions and is also associated with the rare AIDS-related body cavity-based B-cell lymphoma, non-AIDS-associated body cavity-based B-cell lymphomas, and multicentric Castleman's disease [Cesarman et al, 1995Boshoff et al, 1995;Huang et al, 1995;Soulier et al, 1995]. HHV-8 was detected in 8% of infants<15 months of age in Zambia, where a linear increase in seroprevalence with age was noticed that reflects the endemic nature of HHV-8 infection (47% in 14-19-year-olds to 71% in persons aged≥50 years) [Kasolo et al, 1997;Olsen et al, 1998].…”

Section: Introductionmentioning

confidence: 99%

HHV‐8 subtypes in South Africa: Identification of a case suggesting a novel B variant

Treurnicht

Engelbrecht

Taylor

et al. 2001

Journal of Medical Virology

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Human herpesvirus 8 (HHV-8) has been identified as the causative agent for all forms of Kaposi's sarcoma and is also associated with the development of body cavity-based B-cell lymphomas and multicentric Castleman's disease. HHV-8 genomes are now classified into five major subtypes (A-E) that reflect sequence heterogeneity in the highly variable open reading frame (ORF) K1. To identify HHV-8 subtypes associated with different forms of Kaposi's sarcoma, we compared the ORF 26 and ORF-K1 gene sequences from South African patients with the prototype strains of the major subtypes, as well as published sequences from other African strains. DNA prepared from Kaposi's sarcoma biopsies and/or peripheral blood lymphocytes were available from 14 patients with postrenal transplant (iatrogenic) Kaposi's sarcoma, six patients with the African endemic form, and one patient with AIDS-related body cavity-based B-cell lymphoma. We identified a B2 subtype in six patients, four of whom also had a novel B5 type ORF 26 polymorphism. Two patients had B2 type patterns for both the ORF 26 and ORF-K1 genes. The ORF-K1 subtype A5 was identified in samples from three patients with a B3/C2 type polymorphism in the ORF 26 gene. A novel ORF-K1 B variant strain was identified in a patient with African endemic Kaposi's sarcoma, who also had a B3/C2 class ORF 26 pattern. In 58.3% of iatrogenic Kaposi's sarcoma patients, a B5-type ORF 26 gene sequence pattern was identified. No association was found among particular subtypes, geographical origin of patients, or clinical presentation.

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Section: Introductionmentioning

confidence: 99%

HHV‐8 subtypes in South Africa: Identification of a case suggesting a novel B variant

Treurnicht

Engelbrecht

Taylor

et al. 2001

Journal of Medical Virology

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“…Furthermore, there is evidence that classical KS was increasing before the AIDS epidemic, with a doubling of incidence in Sweden over 25 years before 1982 (Dictor andAttewell, 1988). In the USA there is now a consistent decrease in the incidence of AIDS-KS (Beral et al, 1990), with a 4-fold fall among a cohort of homosexual men with AIDS between 1983(Katz et al, 1994 Huang et al, 1995;Boshoff et al, 1995;Dupin et al, 1995;Moore and Chang, 1995;Lebbe et al, 1995;Schalling et al, 1995). The agent was also identified in African endemic KS (Huang et al, 1995;Lebbe et al, 1995;Schalling et al, 1995).…”

Section: Epidemiologymentioning

confidence: 97%

“…In the USA there is now a consistent decrease in the incidence of AIDS-KS (Beral et al, 1990), with a 4-fold fall among a cohort of homosexual men with AIDS between 1983(Katz et al, 1994 Huang et al, 1995;Boshoff et al, 1995;Dupin et al, 1995;Moore and Chang, 1995;Lebbe et al, 1995;Schalling et al, 1995). The agent was also identified in African endemic KS (Huang et al, 1995;Lebbe et al, 1995;Schalling et al, 1995). Furthermore viral sequences were found in KS lesions from immunosuppressed transplant recipients (Lebbe et al, 1995;Boshoff et al, 1995) and HIVnegative homosexual men (Boshoff et al, 1995;Moore and Chang, 1995) (Table I).…”

Section: Epidemiologymentioning

confidence: 99%

“…Furthermore viral sequences were found in KS lesions from immunosuppressed transplant recipients (Lebbe et al, 1995;Boshoff et al, 1995) and HIVnegative homosexual men (Boshoff et al, 1995;Moore and Chang, 1995) (Table I). Minor nucleic acid sequence variations have been detected, implying viral polymorphism (Huang et al, 1995;Moore and Chang, 1995). Northern blot analysis of AIDS-KS lesions confirmed that in about 20% of cases the viral orfs were expressed (Huang et al, 1995;Friedman-Kien, 1995).…”

Section: Epidemiologymentioning

confidence: 99%

“…Minor nucleic acid sequence variations have been detected, implying viral polymorphism (Huang et al, 1995;Moore and Chang, 1995). Northern blot analysis of AIDS-KS lesions confirmed that in about 20% of cases the viral orfs were expressed (Huang et al, 1995;Friedman-Kien, 1995). The viral DNA sequences have also been found in peripheral blood mononuclear cells from KS patients, primarily in B-lymphocytes (Ambroziak et al, 1995;Collandre et al, 1995).…”

Section: Epidemiologymentioning

confidence: 99%

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