Human Herpesviruses 6 and 7

Cleach, Laurence Le; Fillet, Anne Marie; Agut, Henri; Chosidow, Olivier

doi:10.1001/archderm.134.9.1155

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Cited by 16 publications

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“…These results show that HHV-7 can provide a transacting function mediating HHV-6 reactivation from latency. Le Cleach et al[ 13] suggested that HHV-7 would also be a good candidate to play a key role during an adverse drug reaction, because of its similarities with HHV-6, EBV and CMV.…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Hypersensitivity Syndrome due to Carbamazepine Associated with Reactivation of Human Herpesvirus 7

Hara¹,

Kobayashi²,

Yokoyama³

et al. 2005

Dermatology

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We report a 63-year-old Japanese man with epilepsy who developed skin eruptions, liver dysfunction, high fever, leukocytosis and atypical lymphocytosis 4 weeks after he had started taking carbamazepine. Titers of human herpesvirus 7 (HHV-7)-specific IgG antibodies were significantly increased and HHV-7 DNA was detected in his serum by polymerase chain reaction. These findings suggested that reactivation of HHV-7 could contribute to the development of drug-induced hypersensitivity syndrome.

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Section: Discussionmentioning

confidence: 99%