Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children<sup>1</sup>

Ansari, Asad; Li, Shaobing; Abzug, Mark J.; Weinberg, Adriana

doi:10.3201/eid1008.030788

Cited by 37 publications

(33 citation statements)

References 30 publications

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“…Only one infant with HHV‐6 had a suspected seizure and one had a bulging fontanelle. There were no HPeV or HHV‐6 cases identified with aseptic meningitis or encephalitis, which have been associated previously with these viruses [Ansari et al, ; Felsenstein et al, ].…”

Section: Discussionmentioning

confidence: 84%

Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

Messacar¹,

Breazeale

Wei

et al. 2015

J. Med. Virol.

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Human parechovirus (HPeV) and human herpes virus-6 (HHV-6) are acquired commonly in infancy and associated with central nervous system infection. The prevalence of HPeV and HHV-6 in the cerebrospinal fluid (CSF) of infants tested for enterovirus (EV) and herpes-simplex virus (HSV) is unknown. All stored CSF samples from EV or HSV testing in infants less than 6 months of age at Children's Hospital Colorado between January 1, 2010 and December 31, 2011 were tested for HPeV, HHV-6, EV, and HSV by PCR. Clinical characteristics and epidemiological data were collected using retrospective electronic chart review. Of 239 infants tested, 29 cases of EV (12.1%), 7 cases of HPeV (2.9%), 5 cases of HHV-6 (2.1%), and 5 cases of HSV (2.1%) were identified with no bacterial co-infections. HPeV cases occurred between July and October in infants with median age of 24 days. Infants with HPeV had a median maximum temperature of 39 °C, median fever duration of 3 days and median peripheral white blood cell count of 5.2 × 10(3)/μL. HHV-6 cases occurred in infants with median age of 61 days without seasonality. Five percent of infants less than 6 months of age undergoing testing for EV or HSV have HPeV or HHV-6 in the CSF. Targeting testing of HPeV towards febrile infants less than 2 months of age with leukopenia in the late summer to early fall, and HHV-6 towards older infants may increase diagnostic yield. The clinical and fiscal impact of testing infants for HPeV and HHV-6 needs to be determined.

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Section: Discussionmentioning

confidence: 84%

Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

Messacar¹,

Breazeale

Wei

et al. 2015

J. Med. Virol.

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“…The overall incidence of symptomatic HHV6 infection may be low. DNA PCR found HHV6 in only 3 of 245 CSF samples from children less than 2 months of age with possible sepsis or neurologic symptoms (Ansari et al., 2004). An association with childhood acute lymphoblastic leukemia has not been confirmed (Seror et al., 2008).…”

Section: Primary Hhv6 Infectionmentioning

confidence: 99%

Human herpes virus 6B: A possible role in epilepsy?

et al. 2008

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Summary Human herpes virus 6 (HHV6) infection is nearly ubiquitous in childhood and may include central nervous system invasion. There are two variants, HHV6A and HHV6B. Usually asymptomatic, it is associated with the common, self‐limited childhood illness roseola infantum and rarely with more severe syndromes. In patients with immune compromise, subsequent reactivation of viral activity may lead to severe limbic encephalitis. HHV6 has been identified as a possible etiologic agent in multiple sclerosis, myocarditis, and encephalitis. A preponderance of evidence supports an association between HHV6 and febrile seizures. An ongoing multicenter study is investigating possible links between HHV6 infection, febrile status epilepticus, and development of mesial temporal sclerosis (MTS). Investigation of temporal lobectomy specimens showed evidence of active HHV6B but not HHV6A replication in hippocampal astrocytes in about two‐thirds of patients with MTS but not other causes of epilepsy. It has been suggested that HHV6B may cause “excitotoxicity” by interfering with astrocyte excitatory amino acid transport. Although conventional inflammatory changes are not found in most MTS specimens, inflammatory modulators may play a role in neuronal injury leading to MTS as well. If the link between early viral infection, complex or prolonged febrile seizures, and later development of intractable temporal lobe epilepsy is confirmed, new therapeutic approaches to a common intractable epilepsy syndrome may be possible.

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“…A study by Ansari et al (2004) showed that HHV-6 DNA was found in 2 of 245 CSF samples from pediatric patients with meningitis who lacked evidence of another microbiologic cause. [23]. Interestingly, we had reported three children with HHV-6 DNA in CSF and with meningitis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Presentations of HHV-6 Infection in Infants and Children in Kuwait: A Retrospective Study

Madi

Altawalah²,

Al‐Nakib³

2014

AiM

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Clinical manifestations of human herpesvirus 6 (HHV-6) have not been clearly defined, and the role of HHV-6 in human disease among infants and children in Kuwait remains to be fully elucidated. A retrospective study covering the period between 2008 and 2014 was conducted on infants and children aged from 1 month to 5 years. Blood and CSF samples from infants and children who presented with symptoms suggestive HHV-6 infection were subjected to PCR test for HHV-6. Results showed that 9.3% (n = 42) of infants and children were positive for HHV-6. Fever was the most noticeable symptoms, presenting in 50% (n = 21) of the patients. Also, neutropenia was highly associated with HHV-6 infection, where it presented in 35.8% (n = 15) of infants and children. Our results provided important information about the clinical outcome of HHV-6 infection among infants and children in Kuwait.

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Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children¹

Abstract: Human herpesviruses 6 and 7 were infrequently found in cerebrospinal fluid of children with central nervous system infection.

Cited by 37 publications

References 30 publications

Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

Human herpes virus 6B: A possible role in epilepsy?

Clinical Presentations of HHV-6 Infection in Infants and Children in Kuwait: A Retrospective Study

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Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1

Abstract: Human herpesviruses 6 and 7 were infrequently found in cerebrospinal fluid of children with central nervous system infection.

Cited by 37 publications

References 30 publications

Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus

Human herpes virus 6B: A possible role in epilepsy?

Clinical Presentations of HHV-6 Infection in Infants and Children in Kuwait: A Retrospective Study

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Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children¹