Human<i>Borrelia miyamotoi</i>Infection in the United States

Krause, Peter J.; Narasimhan, Sukanya; Wormser, Gary P.; Rollend, Lindsay; Fikrig, Erol; Lepore, Timothy J.; Barbour, Alan G.; Fish, Durland

doi:10.1056/nejmc1215469

Cited by 226 publications

(164 citation statements)

References 5 publications

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“…Initially the public health significance of B. miyamotoi was poorly understood; however, recent studies in Russia have demonstrated that Old World strains of B. miyamotoi, transmitted by I. persulcatus, cause an influenza-like illness with relapsing fever (Platonov et al 2011). In North America, meningoencephalitis was recently described in an elderly immunocompromised patient and from results of a serosurvey of patients from southern New England and New York, B. miyamotoi infection can cause a viral-like illness (Krause et al 2013). These studies support the contention that B. miyamotoi is yet another of the guild of pathogens, which includes the agents of Lyme disease, anaplasmosis, babesiosis, Powassan virus, and the Ehrlichia muris-like agent, associated with blacklegged ticks in North America (Chowdri et al 2013).…”

Section: Potential Tick-borne Bacterial Pathogensmentioning

confidence: 99%

The Biological Survey of Canada: A Personal History

Danks¹

2017

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Section: Potential Tick-borne Bacterial Pathogensmentioning

confidence: 99%

The Biological Survey of Canada: A Personal History

Danks¹

2017

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“…Lyme disease, caused by Borrelia burgdorferi, represents the most frequently reported tick-borne illness (14). Other bacterial agents, such as Anaplasma, Ehrlichia, Rickettsia, and other Borrelia species, as well as the protozoan Babesia contribute to the overall spectrum of tick-borne disease (1,6,7,(14)(15)(16). Conversely, viral causes are diagnosed in only a fraction of tick-borne disease cases (14).…”

mentioning

confidence: 99%

Virome Analysis of Amblyomma americanum, Dermacentor variabilis, and Ixodes scapularis Ticks Reveals Novel Highly Divergent Vertebrate and Invertebrate Viruses

Tokarz

Williams

Sameroff

et al. 2014

J Virol

195

214

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A wide range of bacterial pathogens have been identified in ticks, yet the diversity of viruses in ticks is largely unexplored. In the United States, Amblyomma americanum, Dermacentor variabilis, and Ixodes scapularis are among the principal tick species associated with pathogen transmission. We used high-throughput sequencing to characterize the viromes of these tick species and identified the presence of Powassan virus and eight novel viruses. These included the most divergent nairovirus described to date, two new clades of tick-borne phleboviruses, a mononegavirus, and viruses with similarity to plant and insect viruses. Our analysis revealed that ticks are reservoirs for a wide range of viruses and suggests that discovery and characterization of tickborne viruses will have implications for viral taxonomy and may provide insight into tick-transmitted diseases. IMPORTANCETicks are implicated as vectors of a wide array of human and animal pathogens. To better understand the extent of tick-borne diseases, it is crucial to uncover the full range of microbial agents associated with ticks. Our current knowledge of the diversity of tick-associated viruses is limited, in part due to the lack of investigation of tick viromes. In this study, we examined the viromes of three tick species from the United States. We found that ticks are hosts to highly divergent viruses across several taxa, including ones previously associated with human disease. Our data underscore the diversity of tick-associated viruses and provide the foundation for further studies into viral etiology of tick-borne diseases.

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“…16 Clinical manifestations include a viral-like illness, although meningoencephalitis has been reported. 17,18 Although diagnostic testing for this organism is not routinely available, serology and PCR testing can be performed in certain labs. Doxycycline and/ or ceftriaxone are effective treatments.…”

Section: B Miyamotoimentioning

confidence: 99%

Diseases from North America: focus on tick-borne infections

Nathavitharana

Mitty

2015

Clinical Medicine

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Tick-borne infections are seen throughout the United States, with varying geographical locations. Many of these infections are also increasingly seen in Europe. Certain ticks (eg Ixodes) can transmit more than one infection. Diagnosis, particularly in early infection, can be challenging and therefore knowledge of the distinguishing clinical features and epidemiology of these diseases is important. Testing for Lyme disease often causes confusion for patients and medical providers, as serological tests may be negative in early infection and conversely may be positive for years after infection. Newer tests, such as the C6 ELISA, may play a role in Lyme diagnosis. Additionally, the value of a simple blood fi lm should not be underestimated for diagnosing babesiosis and anaplasmosis. In certain situations, empiric therapy may be required for tick-borne infections as severe illness with multiorgan failure can occur, particularly in older and immunocompromised hosts. This review describes the more commonly seen tick-borne infections: Lyme, babesiosis, anaplasmosis and Rocky Mountain Spotted Fever. More recently identifi ed tick-borne infections, such as southern tick-associated rash illness and Borrelia miyamotoi, are also covered.Tick-borne infections are seen throughout the United States, with varying geographical locations. Diagnosis, particularly in early infection, can be challenging and severe illness can occur. In addition, certain ticks (eg Ixodes scapularis) can transmit more than one infection. This review describes the more commonly seen tick-borne infections. Lyme diseaseIn the United States, Lyme disease is the most common reportable vector-borne disease. 1 It is caused by Borrelia burgdorferii, which is transmitted by the Ixodes tick. This is in contrast to Lyme disease in Europe and Asia that is primarily caused by B afzelii and B garinii. In the US, the Centers for Disease Control and Prevention (CDC) estimates the incidence of Lyme disease to be as high as 300,000 cases per year. 2 The ABSTRACT Authors:

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HumanBorrelia miyamotoiInfection in the United States

Cited by 226 publications

References 5 publications

The Biological Survey of Canada: A Personal History

The Biological Survey of Canada: A Personal History

Virome Analysis of Amblyomma americanum, Dermacentor variabilis, and Ixodes scapularis Ticks Reveals Novel Highly Divergent Vertebrate and Invertebrate Viruses

Diseases from North America: focus on tick-borne infections

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