Human IgG xenoreactive antibodies mediate damage to porcine endothelial cells in vitro by both humoral and cellular mechanisms

Cooke, SP; Jd, Pearson; Savage, C. O. S.

doi:10.1016/s0966-3274(97)80024-x

Cited by 29 publications

(18 citation statements)

References 21 publications

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“…This relationship is supported by findings from a study with five individuals with instrumented knee implants and a range of post-operative lower-extremity alignments (Halder et al, 2012). Thirty percent of total knee replacement cases result in postoperative alignment beyond ±3° varus-valgus (Bäthis et al, 2004), while the standard deviations of tibiofemoral alignment are 3° in healthy individuals and 8° in osteoarthritic individuals (Cooke et al, 1997). A 3° difference between model and subject alignment would alter first peak medial contact force predictions by 23% of body-weight and lateral contact force predictions by 14% of body-weight.…”

Section: Discussionmentioning

confidence: 99%

How tibiofemoral alignment and contact locations affect predictions of medial and lateral tibiofemoral contact forces

Lerner

DeMers

Delp

et al. 2015

Journal of Biomechanics

183

164

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Understanding degeneration of biological and prosthetic knee joints requires knowledge of the in-vivo loading environment during activities of daily living. Musculoskeletal models can estimate medial/lateral tibiofemoral compartment contact forces, yet anthropometric differences between individuals make accurate predictions challenging. We developed a full-body OpenSim musculoskeletal model with a knee joint that incorporates subject-specific tibiofemoral alignment (i.e. knee varus-valgus) and geometry (i.e. contact locations). We tested the accuracy of our model and determined the importance of these subject-specific parameters by comparing estimated to measured medial and lateral contact forces during walking in an individual with an instrumented knee replacement and post-operative genu valgum (6°). The errors in the predictions of the first peak medial and lateral contact force were 12.4% and 11.9%, respectively, for a model with subject-specific tibiofemoral alignment and contact locations determined via radiographic analysis, vs. 63.1% and 42.0%, respectively, for a model with generic parameters. We found that each degree of tibiofemoral alignment deviation altered the first peak medial compartment contact force by 51N (r2=0.99), while each millimeter of medial-lateral translation of the compartment contact point locations altered the first peak medial compartment contact force by 41N (r2=0.99). The model, available at www.simtk.org/home/med-lat-knee/, enables the specification of subject-specific joint alignment and compartment contact locations to more accurately estimate medial and lateral tibiofemoral contact forces in individuals with non-neutral alignment.

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Section: Discussionmentioning

confidence: 99%

How tibiofemoral alignment and contact locations affect predictions of medial and lateral tibiofemoral contact forces

Lerner

DeMers

Delp

et al. 2015

Journal of Biomechanics

183

164

View full text Add to dashboard Cite

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“…Cooke et al found that in varus knee OA (a proxy for medial compartment OA) femoral geometry was abnormal (reduced condylar-hip angle) but tibial plateau-ankle geometry was similar to non-OA controls, while in valgus knee OA (a proxy for lateral compartment knee OA) the opposite held, with a finding of abnormal tibial geometry but normal femoral geometry [7]. Furthermore, Gulati et al found in surgical specimens that both tibial and femoral lesions were more posterior in lateral compartment knee OA than in medial, corresponding to sites of T-F contact during extension phase of gait for medial lesions but to flexion angles above those occurring in single leg stance of the gait cycle for lateral lesions [8].…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

Niu

Guermazi

Liu

et al. 2017

Osteoarthritis and Cartilage

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Objective-Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis. The objective of the present study was to characterize MRI abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA.Method-200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade≥2 and joint space narrowing (JSN)>0 in the lateral compartment but JSN=0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10% cartilage area affected, with ≥25% bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values.Results-IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR=135.2 for size of cartilage lesion, 95%CI 42.7-427.4; OR= 145.4 for large size bone marrow lesions (BML), 95%CI 41.5-509.5; OR =176 for meniscal tears, 95%CI 59.8-517.7; IM-ROA: OR=28.4 for size of cartilage lesion, 95%CI 14.7-54.7; OR= 38.1 for size of BML, 95%CI 12.7-114; OR =37.0 for meniscal tears, 95%CI 12-113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur.Conclusion-IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.

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“…For example, varus or valgus malalignment results in degeneration of the medial or lateral tibiofemoral compartment of the knee, respectively. 3,4 Although simple patterns of cartilage lesions are well known clinically, there is a lack of a quantitative method to both classify such patterns and precisely characterize lesion size and location.…”

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confidence: 99%

Topographic Patterns of Cartilage Lesions in Knee Osteoarthritis

et al. 2009

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Objective:Treatments for articular cartilage lesions could benefit from characterization of lesion patterns and their progression to end-stage osteoarthritis. The objective of this study was to identify, quantitatively, topographic patterns of cartilage lesions in the human knee.Design:Photographs were taken of 127 unilateral distal femora (from 109 cadavers and 18 arthroplasty remnants) with full-thickness cartilage lesions. Using digital image analysis, the lesions were localized, and normalized lesion size was determined for the patellofemoral groove (PFG) and the lateral and medial femoral condyles (LFC and MFC, respectively). Samples were classified into patterns using cluster analysis of the lesion size at each compartment. For each pattern, maps showing the extent and frequency of lesions were created.Results:Four main patterns (a-d) were identified (each P < 0.001), with the lesion size varying from small (a) to large in distinct regions (b-d). Pattern b had a predominant lesion (23% area) in the MFC and smaller (<3%) lesions elsewhere. Pattern c had predominant lesions in the LFC (19%) and MFC (10%). Pattern d had a predominant lesion in the PFG (15%) and smaller lesions in the MFC (6%) and LFC (2%). The subpatterns of a (a1-a3) had relatively small lesions, with similarity between a2 and b and between a3 and d.Conclusion:The present methods facilitated quantitative identification of distinct topographic patterns of full-thickness cartilage lesions, based on lesion size and location. These results have implications for stratifying osteoarthritis patients using precise quantitative methods and, with additional longitudinal data, targeting cartilage treatments.

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Human IgG xenoreactive antibodies mediate damage to porcine endothelial cells in vitro by both humoral and cellular mechanisms

Cited by 29 publications

References 21 publications

How tibiofemoral alignment and contact locations affect predictions of medial and lateral tibiofemoral contact forces

How tibiofemoral alignment and contact locations affect predictions of medial and lateral tibiofemoral contact forces

Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

Topographic Patterns of Cartilage Lesions in Knee Osteoarthritis

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