Human immune-cell response towards diverse xenogeneic and allogeneic decellularized biomaterials

Rieder, Erwin; Steinacher-Nigisch, Anneliese; Weigel, Günter

doi:10.1016/j.ijsu.2016.06.042

Cited by 30 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decellularized tissue may expose new protein, and the decellularization protocol may also have a significant impact on the response of human mononuclear cells [59]. Rieder et al [60] reported that decellularized vascular wall elicited more immune cell proliferation than native equivalent, and hence, it proved the above hypothesis. It also hypothesized that opsonization would be the way of inflammation response and can occur through preformed antibody or binding of unspecific plasma protein to the surface.…”

Section: Immunogenicity Against Decmmentioning

confidence: 90%

Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

Yeleswarapu¹,

Chameettachal²,

Bera³

et al. 2020

Xenotransplantation - Comprehensive Study

View full text Add to dashboard Cite

3D bioprinting brings new aspirations to the tissue engineering and regenerative medicine research community. However, despite its huge potential, its growth towards translation is severely impeded due to lack of suitable materials, technological barrier, and appropriate validation models. Recently, the use of decellularized extracellular matrices (dECM) from animal sources is gaining attention as printable bioink as it can provide a microenvironment close to the native tissue. Hence, it is worth exploring the use of xenogeneic dECM and its translation potential for human application. However, extensive studies on immunogenicity, safety-related issues, and animal welfare-related ethics are yet to be streamlined. In addition, the regulatory concerns need to be addressed with utmost priority in order to expedite the use of xenogeneic dECM bioink for 3D bioprinted implantable tissues for human welfare.

show abstract

Section: Immunogenicity Against Decmmentioning

confidence: 90%

Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

Yeleswarapu¹,

Chameettachal²,

Bera³

et al. 2020

Xenotransplantation - Comprehensive Study

View full text Add to dashboard Cite

show abstract

“…Animal-free matrices are very useful for 3D bioprinting of grafts [ 35 ] and decellularized matrices are ideal materials for generating a bioink [ 35 ]. As animal-derived matrices have to deal with xenogenic and ethical issues [ 36 ], plant-derived matrices are a worthy option. Matrices obtainable via plant tissue decellularization [ 37 ] are extremely challenging in the tissue engineering field and scaffolding for 3D cell cultures, however, they could need smart functionalization because of some lack of biochemical mammalian cues [ 38 ].…”

Section: Biomaterials: Overview Of Natural Polymersmentioning

confidence: 99%

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

View full text Add to dashboard Cite

Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

show abstract

“…So far, the only clinical application of xenotransplantation in the field of cardiac repair is the endoventricular injection of a decellularized extracellular porcine myocardial matrix. The outcomes of this trial (NCT02305602) will reveal if this strategy is worth a further pursuit considering that decellularized porcine pulmonary arteries were previously shown to induce a strong immune cell response in vitro 47 .…”

Section: Cell Therapy Of Ischemic Heart Diseasementioning

confidence: 99%

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

Berry

Zhu

Tang

et al. 2019

Circulation Research

View full text Add to dashboard Cite

On March 1 and 2, 2018, the National Institutes of Health 2018 Progenitor Cell Translational Consortium (PCTC) and Cardiovascular Bioengineering Symposium (CVBE) was held at the University of Alabama at Birmingham. Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the meeting. Over 150 attendees were present for more than 40 scientists presenting their latest works on engineering human functional myocardium for disease modeling, drug development, and heart failure research. The scientists, engineers and physicians in the field of cardiovascular sciences, met and discussed on the most recent advances in their works and propose future strategies in overcoming the major roadblocks of cardiovascular bioengineering and therapy. Particular emphasis was given for manipulation and using of stem/progenitor cells, biomaterials, and methods to provide molecular, chemical and mechanical cues to cells in order to influence their identity and fate in vitro and in vivo. Collectively, these works are profoundly impacting and progressing toward deciphering the mechanisms and developing novel treatments for left ventricular dysfunction of failing hearts. Here we present some important perspectives that emerged from this meeting.

show abstract

Human immune-cell response towards diverse xenogeneic and allogeneic decellularized biomaterials

Abstract: Even decellularized or cross-linked xenogenic cardiovascular and reconstructive biomaterials elicit increased human immune responses not seen in the majority of allogenic specimens tested.

Cited by 30 publications

References 29 publications

Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

Contact Info

Product

Resources

About