Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis

Rosenthal, David G.; LeBoit, Philip E.; Klumpp, Lesley; Berger, Timothy G.

doi:10.1001/archderm.1991.01680020074008

Cited by 169 publications

(62 citation statements)

References 17 publications

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“…These results indicate that the remis sion of EPF is correlated with the increased serum concen tration of IFN-y. Treatment with indomethacin is known to be very effec tive in this condition [3,4] EPF has been reported in association with human immu nodeficiency virus (HIV) infection [12, 13|, although EPF seen in patients with HIV infection is clinically distinct from classical EPF (Ofuji's disease) [3,13]. It is unclear why a condition similar to EPF often occurs in patients with HIV infection.…”

Section: Discussionmentioning

confidence: 99%

Ofuji’s Disease and Cytokines: Remission of Eosinophilic Pustular Folliculitis Associated with Increased Serum Concentrations of Interferon Gamma

Teraki

Imanishi²,

Shiohara³

1996

Dermatology

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Background and Objective: Eosinophilic pustular folliculitis (EPF) is a distinct inflammatory dermatosis of unknown etiology. The aim of this study is to evaluate the serum levels of cytokines in 3 patients with EPF before and after treatment with indomethacin. Results: Serum levels of interleukin 4 (IL-4) were elevated in patients with EPF. The remission of EPF was associated with increased serum concentrations of interferon γ with no essential change of serum levels of IL-4. Conclusion: These results suggest that subtle changes in serum levels of cytokines are involved in the remission of EPF and that indomethacin may provide the remission of EPF by altering cytokine production in patients with EPF

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Section: Discussionmentioning

confidence: 99%

Ofuji’s Disease and Cytokines: Remission of Eosinophilic Pustular Folliculitis Associated with Increased Serum Concentrations of Interferon Gamma

Teraki

Imanishi²,

Shiohara³

1996

Dermatology

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“…The cause of eosinophilic folliculitis is obscure. It is considered to be related to eosinophilia, elevated IgE level, low CD4 count [23]and some microorganisms such as Pityrosporum [20, 21]and Demodex [20]. All 3 of the present cases showed fungal spores and it is possible that this skin flora plays some pathogenic role.…”

Section: Discussionmentioning

confidence: 82%

Mucocutaneous Manifestations in Japanese HIV-Positive Hemophiliacs

et al. 2000

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Background: Although various mucocutaneous manifestations have been reported in patients infected with HIV by sexual transmission or intravenous drug use, the prevalence and characteristics of skin disorders in HIV-positive hemophiliacs coinfected with hepatitits C virus (HCV) have rarely been described. Objective: The purpose of this study was to clarify the characteristics of skin disorders in HIV-positive hemophiliacs and to identify differences in comparison with other HIV-positive groups. Methods: A prospective study of the prevalence of mucocutaneous manifestations in 110 Japanese hemophiliacs (53 HIV-positive hemophiliacs including 24 AIDS and 57 HIV-negative hemophiliacs) was performed from July 1997 to July 1998. Result: None of the hemophiliacs developed Kaposi’s sarcoma or sexually transmitted skin diseases. Eosinophilic folliculitis was observed in 3 AIDS patients. The incidence of folliculitis, common warts, seborrheic dermatitis, generalized eczema, oral candidiasis and herpes zoster was higher in HIV-positive than in HIV-negative hemophiliacs (p < 0.05). Although anti-HCV antibody was positive in all HIV-positive hemophiliacs, HCV-related dermatoses such as lichen planus and porphyria cutanea tarda were not observed. Conclusion: Although Kaposi’s sarcoma and sexually transmitted skin diseases such as molluscum contagiosum, condyloma, and scabies are frequently associated with HIV, they were not found in the HIV-positive hemophiliacs in our study. HIV infection-related mucocutaneous manifestations are influenced not only by the presence of HIV but also by other factors such as the mode of transmission and sexual habit.

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“…Furthermore, some patients with Ofuji’s disease were HIV positive [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20]. For these reasons, both serological and molecular methods were used to detect evidence of infection from HTLVs or related retroviruses in this patient.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Retroviral Involvement in an Italian Patient with Ofuji’s Disease

et al. 1999

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Ofuji’s disease, also known as ‘eosinophilic pustular folliculitis’, is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji’s disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46I) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.

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Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis

Cited by 169 publications

References 17 publications

Ofuji’s Disease and Cytokines: Remission of Eosinophilic Pustular Folliculitis Associated with Increased Serum Concentrations of Interferon Gamma

Ofuji’s Disease and Cytokines: Remission of Eosinophilic Pustular Folliculitis Associated with Increased Serum Concentrations of Interferon Gamma

Mucocutaneous Manifestations in Japanese HIV-Positive Hemophiliacs

Evidence of Retroviral Involvement in an Italian Patient with Ofuji’s Disease

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