Human immunodeficiency virus exanthem

Hulsebosch, H. J.; Claessen, F. A. P.; Ginkel, C.J.W. van; Kuiters, G.R.R.; Goudsmit, Jaap; Lange, Joep M. A.

doi:10.1016/0190-9622(90)70245-d

Cited by 46 publications

(20 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Skin involvement consisted predominantly of a maculopapular rash and disseminated urticaria [3,8,10,35]. No roseolalike or vesicular exanthema like that previously described [1, 2, 9, 36] was noted.…”

Section: Discussionmentioning

confidence: 94%

Symptomatic Primary Infection Due to Human Immunodeficiency Virus Type 1: Review of 31 Cases

Loés

Saussure

Saurat

et al. 1993

Clinical Infectious Diseases

142

View full text Add to dashboard Cite

In this series of 31 patients with acute infection due to human immunodeficiency virus (HIV) type 1, the male-to-female ratio was 3.4:1 and the mean age was 31.3 years. Sexual transmission accounted for 83.9% of cases; 45.2% of the patients were homosexual and 38.7% were heterosexual. The mean duration of symptoms and signs was 21 days (range, 5-60 days). Fever (87.1%) and skin rash (67.7%) were most commonly reported. Physical examination findings were abnormal for 96% of the patients; the oral cavity (76.7%) and the skin (73.3%) were the most frequently involved sites. Thirteen of 25 patients with sexually acquired infection had genital or oral ulcers, whereas five intravenous drug users had none (P = .052). Thrombocytopenia was the most common hematologic abnormality and was detected in 17 of 23 patients tested. P24 antigenemia, an initially negative screening test for HIV antibody, and a low CD4+ lymphocyte count were noted in 23 of 29, 23 of 30, and 14 of 21 tested patients, respectively.

show abstract

Section: Discussionmentioning

confidence: 94%

Symptomatic Primary Infection Due to Human Immunodeficiency Virus Type 1: Review of 31 Cases

Loés

Saussure

Saurat

et al. 1993

Clinical Infectious Diseases

142

View full text Add to dashboard Cite

show abstract

“…A few studies have reported histopathological findings of skin eruptions associated with primary HIV infection (4, 7–11). Lymphocyte perivascular infiltration in the upper dermis and exocytosis in the epidermis are most commonly observed.…”

Section: Discussionmentioning

confidence: 99%

A Case of Symptomatic Primary HIV Infection

Kobayashi

Segawa

Kawashima

et al. 2005

The Journal of Dermatology

View full text Add to dashboard Cite

A 30-year-old homosexual Japanese man had fourteen days of fever, malaise, appetite loss, sore throat, and four days of diarrhea and slightly congested eyes before he developed a skin eruption. He presented with measles-like exanthems on his face, trunk, and extremities. Deep red enanthems were seen on his left buccal mucosa opposite the premolar teeth, and whitish enanthems were seen on the buccal and gingival mucosa. HIV RNA was detected at the high concentration of 5.8 x 10(6) copies /ml in his serum. Cerebrospinal fluid examination revealed aseptic meningitis with 5,488 copies /ml of HIV RNA. Anti-HIV 1 antibodies against Gp160 and p24 tested by Western blot assay showed seroconversion on day 5 of his admission, seven days after he developed the skin eruptions. The fever lasted for three weeks from the initial onset, and the skin eruptions lasted for twelve days. Histopathologically, a mononuclear cell infiltration was seen mainly in the upper dermis surrounding small vessels and sweat ducts, with CD8+ cytotoxic T lymphocytes predominant. Additionally, CD1a+ putative interdigitating dendritic cells had also infiltrated perivascularly, and were surrounded by CD8+ and CD4+ T cells. In situ hybridization study failed to detect HIV products in skin biopsy specimens. Our findings suggested that CD8+ T cells and their interaction with CD1a+ dendritic cells in the skin may be important in inducing skin manifestations in acute HIV infections.

show abstract

“…It is known that this can either be due to a direct cytotoxic effect of the virus, as in varicella, or the result of aT-ceIl-mediated immunoreaction, as in rubella. Secondary syphilis is the main differential diagnosis of the HIV exanthema [6], such as pityriasis rosea, and other viral or drug-induced exanthemas. It must be emphasised that the histopathological features of HIV exanthema are not diagnostic for HIV infection, as the histology is the same as in many other virus infections [8].…”

Section: Acute Exanthema In Hiv Diseasementioning

confidence: 99%

Skin Diseases Associated with HIV Infection

Innocenzi

2001

Current Topics in Pathology

View full text Add to dashboard Cite

Human immunodeficiency virus exanthem

Cited by 46 publications

References 6 publications

Symptomatic Primary Infection Due to Human Immunodeficiency Virus Type 1: Review of 31 Cases

Symptomatic Primary Infection Due to Human Immunodeficiency Virus Type 1: Review of 31 Cases

A Case of Symptomatic Primary HIV Infection

Skin Diseases Associated with HIV Infection

Contact Info

Product

Resources

About