Human immunodeficiency virus (HIV)-associated duodenal lymphoma

Nakazuru, Shoichi; Yoshio, Toshiyuki; Ogawa, Yoshiyuki; Yuguchi, Kiyonori; Hasegawa, Harumi; Sakakibara, Yuko; Kodama, Y; Uehira, Tomoko; Mita, Eiji

doi:10.1055/s-0030-1256940

Cited by 2 publications

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“…The study showed that abdominal pain and weight loss were the two most common symptoms [10] . Nakazuru et al [11] reported an unusual case of a HIV-associated duodenal lymphoma, which presented with melena. Gynaecological occurrences of lymphoma in HIV positive patients are less common although there is a case report of a HIV-associated lymphoma of the ovary [12] .…”

Section: Discussionmentioning

confidence: 99%

Right iliac fossa lymphoma in an HIV positive patient: A diagnostic dilemma

Sinnott

Natin

Foster

2016

International Journal of Surgery Case Reports

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HighlightsAn association has been established between HIV and lymphoma.Lymphoma can present with non-specific or unusual symptoms.Lymphoma can also present in patients with well-controlled HIV.Lymphoma in HIV patients is an important differential but is often diagnosed at a late stage in the UK.It is important that suspicion of lymphoma is raised in patients with HIV.It is important that a multidisciplinary approach to diagnosis is taken early on to allow prompt management of this condition

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Section: Discussionmentioning

confidence: 99%

Right iliac fossa lymphoma in an HIV positive patient: A diagnostic dilemma

Sinnott

Natin

Foster

2016

International Journal of Surgery Case Reports

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Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYCrearrangements: Case report and literature review

Tanaka

Nagata²,

Mine³

et al. 2013

WJG

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Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-year-old homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139(th) day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases.

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Human immunodeficiency virus (HIV)-associated duodenal lymphoma

Cited by 2 publications

References 0 publications

Right iliac fossa lymphoma in an HIV positive patient: A diagnostic dilemma

Right iliac fossa lymphoma in an HIV positive patient: A diagnostic dilemma

Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYCrearrangements: Case report and literature review

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