Human Immunodeficiency Virus Reverse Transcriptase

Wendeler, Michaela; Miller, Jennifer T.; Grice, Stuart F. J. Le

doi:10.1007/b135974_19

Cited by 2 publications

(3 citation statements)

References 195 publications

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“…12.10) (Sarafianos et al 2009; Wendeler et al 2009). During the synthesis of minus-strand DNA, the RNase H cleaves the RNA strand of the resulting RNA–DNA duplex at multiples sites.…”

Section: 3 Reverse Transcriptase (Rna-dependent Dna Polymerase)mentioning

confidence: 99%

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Viral Polymerases

Choi

2011

Advances in Experimental Medicine and Biology

106

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Viral polymerases play a central role in viral genome replication and transcription. Based on the genome type and the specific needs of particular virus, RNA-dependent RNA polymerase, RNA-dependent DNA polymerase, DNA-dependent RNA polymerase, and DNA-dependent RNA polymerases are found in various viruses. Viral polymerases are generally active as a single protein capable of carrying out multiple functions related to viral genome synthesis. Specifically, viral polymerases use variety of mechanisms to recognize initial binding sites, ensure processive elongation, terminate replication at the end of the genome, and also coordinate the chemical steps of nucleic acid synthesis with other enzymatic activities. This review focuses on different viral genome replication and transcription strategies, and the polymerase interactions with various viral proteins that are necessary to complete genome synthesis.

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“…12.10) (Sarafianos et al 2009; Wendeler et al 2009). During the synthesis of minus-strand DNA, the RNase H cleaves the RNA strand of the resulting RNA–DNA duplex at multiples sites.…”

Section: 3 Reverse Transcriptase (Rna-dependent Dna Polymerase)mentioning

confidence: 99%

“…( e ) dsDNA synthesis. Ligation of a circular intermediate produces a linear dsDNA with terminal repeats containing R and promoter regions (U3 and U5) at both ends (Wendeler et al 2009)…”

Section: Fig 121mentioning

confidence: 99%

Viral Polymerases

Choi

2011

Advances in Experimental Medicine and Biology

106

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“…Research on retroviruses got an enormous boost in the mid-1980s after AIDS became one of the main focus of research in virology and medicine. Obviously, most of the research on RT over the last four decades has been dominated by studies of the RT of human immunodeficiency virus (HIV) [91]. RT of HIV is one of key targets for the some of the drugs which are being tried against AIDS.…”

Section: Rdrp Of Rna Viruses and Rna Replicationmentioning

confidence: 99%

Template-Directed Biopolymerization: Tape-Copying Turing Machines

Sharma

Chowdhury

2012

Biophys. Rev. Lett.

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DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear polymer as the corresponding template. The machine utilizes input chemical energy to move along the template which also serves as a track for the movements of the machine. In the Alan Turing year 2012, it is worth pointing out that these machines are "tape-copying Turing machines". We review the operational mechanisms of the polymerizer machines and their collective behavior from the perspective of statistical physics, emphasizing their common features in spite of the crucial differences in their biological functions. We also draw attention of the physics community to another class of modular machines that carry out a different type of template-directed polymerization. We hope this review will inspire new kinetic models for these modular machines. * Contribution in the Alan Turing year 2012

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Human Immunodeficiency Virus Reverse Transcriptase

Cited by 2 publications

References 195 publications

Viral Polymerases

Viral Polymerases

Template-Directed Biopolymerization: Tape-Copying Turing Machines

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