Human implantation: The complex interplay between endometrial receptivity, inflammation, and the microbiome

Sehring, Jacqueline; Beltsos, Angeline; Jeelani, Roohi

doi:10.1016/j.placenta.2021.12.015

Cited by 47 publications

(35 citation statements)

References 84 publications

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“…The two processes of intravascular trophoblast invasion and helical artery remodeling during gestation in humans are dependent on proper regulation of the maternal immune system ( 20 , 21 ). In early trimester, embryo implantation is a pro-inflammatory state, where pro-inflammatory cytokines released by immune cells as well as the endometrium itself promote tissue remodeling and angiogenesis to assist embryo implantation ( 22 ). However, pregnancy requires regulatory and anti-inflammatory cytokines released by immune cells such as Tregs to control pro-inflammatory cytokines and induce maternal immune tolerance to fetal antigens to ensure a healthy pregnancy ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Wang

Tong

2023

Front. Immunol.

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BackgroundA growing evidence suggests that immune cells play a significant role in the pathogenesis of hypertensive disorders of pregnancy (HDP).Over the past 20 years, several studies have been conducted on the role of immune cells in hypertensive disorders of pregnancy. This study used bibliometric analysis to assess research hotspots and future trends in studies on immune cells in hypertensive disorders of pregnancy.MethodsWe extracted all relevant literature on immune cells and hypertensive disorders of pregnancy from the Web of Science core collection for the period of 2001 to 2021. We used VOS Viewer, CiteSpace, R-bibliometrix and Python for bibliometric analysis.ResultsWe identified 2,388 records published in 593 journals by 9,886 authors from 2,174 universities/institutions in 91 countries/regions. The number of publications tended to increase over time, with the highest number of publications in 2021, up to 205. The USA was the country with the most publications. UNIVERSITY OF MISSISSIPPI was the most influential institution. Lamarca B, Romero R, and Saito S were the most prolific authors. Finally, three research hotspot clusters were identified based on keywords, which reflected the role of immune cells in the development of hypertensive disorders of pregnancy, the current research status,and predicted hot spots for future research.ConclusionsOur study systematically analyzed the role of immune cells in the pathogenesis of hypertensive disorders of pregnancy in the last 20 years. Our results indicated that immune cells, such as T cells, natural killer (NK) cells,and macrophages, and the cytokines released such as TNF-α, IFN-γ in the maternal circulation and at the maternal-fetal interface would influence the development of hypertensive disorders of pregnancy and we need further investigate the role of individual immune cells and translational studies to provide new therapeutic perspectives to mitigate adverse perinatal outcomes due to hypertensive disorders of pregnancy. In conclusion, bibliometric studies provide a general overview of immune cells in the study of hypertensive disorders of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Wang

Tong

2023

Front. Immunol.

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“…Current evidence suggests that inflammatory responses are involved in implantation and early pregnancy [ 48 , 49 ]. In the context of ischemia-reperfusion injury, miR-135a-5p suppresses cardio-cerebral ischemic inflammatory damage [ 21 , 22 ], and it has similarly been shown to hamper NLRP3 inflammasome activation and to attenuate associated inflammatory responses [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion

Zhang

et al. 2022

Reprod Biol Endocrinol

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Background Spontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot be identified in roughly half of SA cases. We found miR-135a-5p to be significantly upregulated in SA-associated villus tissues, yet the function it plays in this context has yet to be clarified. This study explored the function of miR-135a-5p and its potential as a biomarker for unexplained SA. Method RT-qPCR was employed for appraising miR-135a-5p expression within villus tissues with its clinical diagnostic values being assessed using ROC curves. The effects of miR-135a-5p in HTR-8/SVneo cells were analyzed via wound healing, Transwell, flow cytometry, EdU, CCK-8, and tube formation assays. Moreover, protein expression was examined via Western blotting, and interactions between miR-135a-5p and PTPN1 were explored through RIP-PCR, bioinformatics analyses and luciferase reporter assays. Results Relative to normal pregnancy (NP), villus tissue samples from pregnancies that ended in unexplained sporadic miscarriage (USM) or unexplained recurrent SA (URSA) exhibited miR-135a-5p upregulation. When this miRNA was overexpressed in HTR-8/SVneo cells, their migration, proliferation, and cell cycle progression were suppressed, as were their tube forming and invasive activities. miR-135a-5p over-expression also downregulated the protein level of cyclins, PTPN1, MMP2 and MMP9. In RIP-PCR assays, the Ago2 protein exhibited significant miR-135a-5p and PTPN1 mRNA enrichment, and dual-luciferase reporter assays indicated PTPN1 to be a bona fide miR-135a-5p target gene within HTR-8/SVneo cells. Conclusion miR-135a-5p may suppress trophoblast migratory, invasive, proliferative, and angiogenic activity via targeting PTPN1, and it may thus offer value as a biomarker for unexplained SA.

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“…The requirements for embryo adhesion in this process are relatively stringent, requiring both sufficient implantation ability of the embryo and endometrium receptivity. Endometrium receptivity, in particular, requires an appropriate level of inflammation, which first ensures that the embryo is protected from the maternal immune system before implantation, and then requires a maternal endometrial inflammatory response after implantation to promote embryo invasion ( Franasiak et al, 2021 ; Sehring et al, 2022 ). However, the embryo’s implantation ability and the endometrium’s receptivity must be obtained concurrently, which is more difficult.…”

Section: The Role Of Evs In Embryo Implantationmentioning

confidence: 99%

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

Fan

Wang

et al. 2023

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs) have become a research hotspot in recent years because they act as messengers between cells in the physiological and pathological processes of the human body. It can be produced by the follicle, prostate, embryo, uterus, and oviduct in the reproductive field and exists in the extracellular environment as follicular fluid, semen, uterine cavity fluid, and oviduct fluid. Because extracellular vesicles are more stable at transmitting information, it allows all cells involved in the physiological processes of embryo formation, development, and implantation to communicate with one another. Extracellular vesicles carried miRNAs and proteins as mail, and when the messenger delivers the mail to the recipient cell, the recipient cell undergoes a series of changes. Current research begins with intercepting and decoding the information carried by extracellular vesicles. This information may help us gain a better understanding of the secrets of reproduction, as well as assist reproductive technology as an emerging marker and treatment.

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Human implantation: The complex interplay between endometrial receptivity, inflammation, and the microbiome

Cited by 47 publications

References 84 publications

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

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