Human Indolethylamine N-Methyltransferase: cDNA Cloning and Expression, Gene Cloning, and Chromosomal Localization

Thompson, Michael A.; Moon, Eunpyo; Kim, Ung Jin; Xu, Jun; Siciliano, Michael J.; Weinshilboum, Richard M.

doi:10.1006/geno.1999.5960

Cited by 69 publications

(93 citation statements)

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“…The 5' upstream regions for two non brain-neuron specific genes (INMT and PLP2) were also sequenced. INMT is known to be expressed in several human tissues such as adult thyroid, adult adrenal gland, adult lung, and fetal lung (Thompson et al 1999), and PLP2 is expressed in colonic epithelial cell (Olivia et al 1993).…”

Section: Methodsmentioning

confidence: 99%

Evolutionary Conservation of 5' upstream Sequence of Nine Genes between Human and Great Apes

Kitano

Saitou

2005

Genes Genet. Syst.

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Nucleotide sequences of nine 5' upstream gene regions for human, chimpanzee, gorilla, and orangutan were determined. We estimated nucleotide differences ( d ) for each region between human and great apes. The overall d was 0.027 (ranged from 0.004 to 0.052). Rates of nucleotide substitution were estimated by using d and divergence times of human, chimpanzee, gorilla, and orangutan. The overall rate of nucleotide substitution between human and other hominoids was estimated to be 0.52-0.85 × 10 -9 . This rate in 5' upstream regions was lower than that of synonymous sites, suggesting that 5' upstream regions have evolved under some functional constraints. Because lower rates have been reported for coding sequences in primates compared to rodents, we also estimated the rate (1.17-1.76 × 10 -9 ) of nucleotide substitutions for the corresponding 5' upstream regions in rodents (mouse/rat comparison). Thus the primate rate was lower than rodent rate also for the 5' upstream regions.

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Section: Methodsmentioning

confidence: 99%

Evolutionary Conservation of 5' upstream Sequence of Nine Genes between Human and Great Apes

Kitano

Saitou

2005

Genes Genet. Syst.

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“…The INMT exhibits wide tissue distribution. Human INMT was expressed in the lung, thyroid, adrenal gland, heart, and muscle but not in the brain (Thompson et al, 1999). Since INMT is predominantly present in peripheral tissues, its main physiological function is presumably non-neural.…”

Section: N-methylationmentioning

confidence: 99%

Phase II Drug Metabolism

Jančová¹,

Siller²

2012

Topics on Drug Metabolism

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“…Nicotine N-methylation is catalyzed by amine N-methyltransferase (Crooks and Godin, 1988;Nwosu and Crooks, 1988). The expression of this cytosolic enzyme is highest in human thyroid, adrenal gland, and lung (Thompson et al, 1999). It has some activity toward tryptamine N-methylation, but otherwise its metabolic functions are not characterized.…”

Section: Liver Enzymes Responsible For Nicotine and Cotinine Metabmentioning

confidence: 99%

“…A preliminary report showed markedly impaired urinary excretion of nicotine NЈ-oxide after nicotine chewing gum administration in two siblings with fish-odor syndrome . A few polymorphisms in amine N-methyltransferase gene have been reported, but their functional significance is unknown (Thompson et al, 1999). UGT1A4 gene has alleles with differences in NNAL glucuronidation (Wiener et al, 2004), and one of the UGT1A9 alleles produces substrate-specific alterations in enzyme activity (Villeneuve et al, 2003).…”

Section: Polymorphisms In Other Enzymes Several Polymorphisms Have Bmentioning

confidence: 99%

“…Low levels of FMO3 have been detected in 96 human kidney (Krause et al, 2003). The expression of amine N-methyltransferase is highest in human thyroid, adrenal gland, and lung (Thompson et al, 1999). UGT1A4 is detected in liver, colon, and gastric and biliary tissue but not in respiratory tract or esophagus (Strassburg et al, 1998;Zheng et al, 2002).…”

Section: F Extrahepatic Nicotine Metabolismmentioning

confidence: 99%

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