Human infections due to Staphylococcus pseudintermedius, an emerging zoonosis of canine origin: report of 24 cases

Somayaji, Ranjani; Priyantha, M. A. R.; Rubin, Joseph E.; Church, Deirdre L.

doi:10.1016/j.diagmicrobio.2016.05.008

Cited by 175 publications

(189 citation statements)

References 24 publications

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“…However, reports of zoonotic transmission of meticillin-susceptible and -resistant S. pseudintermedius between dogs and humans have been published [21]. Guardabassi et al [22] have investigated the occurrence of S. pseudintermedius in infected dogs, their owners and subjects with no daily contact with dogs.…”

Section: Discussionmentioning

confidence: 99%

Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner

et al. 2017

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Introduction. Staphylococcus pseudintermedius, an opportunistic pathogen of dogs and cats, is rarely reported to cause infection in humans. Here, we describe a case of severe skin infection caused by S. pseudintermedius, in a 47-year-old male, a dog owner; to the best of our knowledge, this is the first such case reported from Scotland.Case presentation. The patient presented with a short history of a severe ecthyma-like lesion on his forehead, with smaller lesions on his abdomen and legs. Bacterial culture revealed Clostridium perfringens, thought to be colonizing the wound, and a Staphylococcus species, identified as S. pseudintermedius by matrix-assisted laser desorption/ionization-time of flight MS and confirmed by molecular methods using a PCR-RFLP approach. The patient was treated with flucloxacillin, penicillin V and Fucibet cream, and recovered fully. Zoonotic infection was considered likely; however, screening swabs from his dogs grew S. pseudintermedius of a different clonal type. Both patient and dog strains carried Staphylococcus intermedius exfoliative toxin and leucocidin I, closely related to Panton–Valentine leucocidin, possibly contributing to the severity of the infection. S pseudintermedius, although coagulase positive, is normally negative by rapid slide clumping and latex agglutination tests routinely used to identify Staphylococcus aureus. Hence, S. pseudintermedius may easily be misidentified as a coagulase-negative staphylococcus and considered insignificant.Conclusion. This is, to the best of our knowledge, the first reported case of a human S. pseudintermedius infection in Scotland. Zoonotic transmission of S. pseudintermedius between pets and owners has been shown. However, in this case zoonosis could not be confirmed.

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Section: Discussionmentioning

confidence: 99%

Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner

et al. 2017

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“…In addition to canine health problems, MRSP infection is increasing in humans, especially those with close relationships with dogs (SOMAYAJI et al, 2016;ROBB et al, 2017) Furthermore, antimicrobial resistance surveillance to inform evidence-based empiric therapeutic selection suggested that a new clonal population of MRSP, resistant to most therapeutically antibiotics, is emerging (PRIYANTHA; GAUNT & RUBIN, 2016;VIDELA, 2017). According to KASAI et al (2016), the incidence of MRSP has been increasing worldwide, limiting treatment options.…”

Section: Antibiotic ----------------------------------------------Dismentioning

confidence: 99%

“…In Brazil, a high incidence of MRSP in dogs with pyoderma has been reported over the last few years (LOPES et al, 2015;BOTONI et al, 2016;BOURGUIGNON et al, 2016). Moreover, this microorganism has been increasingly implicated in human infections (SOMAYAJI et al, 2016;ROBB et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Frequency and antimicrobial susceptibility of Staphylococcus pseudintermedius in dogs with otitis externa

et al. 2018

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Infections by Staphyloccocus pseudintermedius in the skin of dogs have been object of studies, since such microorganisms often present multiple resistance to antibiotics. This study aimed to identify and evaluate the antimicrobial susceptibility of Staphylococcus pseudintermedius (SP) strains isolated from dogs with otitis. Swabs from both ears of 52 dogs with otitis (n=104) were included. Bacteria were cultured using Muller-Hinton agar (supplemented with 5% equine blood and incubated at 37°C for 24 to 48 hours. All colonies underwent biochemical evaluation for identification of staphylococci. The identity of colonies as SP was confirmed by polymerase chain reaction. The antimicrobial susceptibility of SP strains was evaluated by disk diffusion. The presence of the gene mecA was evaluated in all SP isolates by PCR. Forty-four SP strains were isolated from swabs of 31 dogs (31/52, 59.6%). Seventy-five percent of the strains were susceptible to cephalexin and 93.2% to amoxicillin plus clavulanic acid. Less than 23% of the strains were susceptible to penicillin. For non-beta-lactam antimicrobials, 63.6% of the strains showed resistance to sulfamethoxazole-trimethoprim, 61.4% to tetracycline, and 38, 64% to enrofloxacin. Aminoglycoside resistance rate was 27.3% for gentamicin. Resistance to oxacillin in vitro was detected in 13 of the 44 strains (29, 55%). A total of 12 strains (27.3%) were positive for mecA gene and five of these 12 strains were susceptible to in vitro oxacillin. Twenty-six (59, 1%) strains were resistant to three or more classes of antimicrobials, and classified as multi resistant. Our results showed high frequency of SP and multi resistant isolates to antimicrobials commonly used in veterinary.

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“…Isolated case reports have identified S. pseudintermedius as a cause of a wound infection in an immunocompromised patient (isolated from pus sample),6 a postoperative infection of a frontal sinus (isolated from pus sample),7 in patients with infections of recently implanted cardiac defibrillator devices (isolated from pus samples)8 9 and a vascular catheter line infection in a bone marrow transplant patient (isolated from blood culture taken from line) 10. More recently, a case series has identified S. pseudintermedius as a cause of infection in several superficial soft-tissue infections, a prosthetic knee and a dialysis vascular access fistula 11. Most of these cases had epidemiological exposure of the patient to dogs.…”

Section: Discussionmentioning

confidence: 99%

A spinal infection withStaphylococcus pseudintermedius

Darlow¹,

Paidakakos

Sikander

et al. 2017

BMJ Case Reports

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We present a case of a 60-year-old woman with an invasive spinal infection with associated with a 15-year-old spinal fixation device and epidemiological contact with dogs. It was confirmed on blood culture and culture from pus from the epidural abscess and successfully treated using similar treatment as for a infection 6 weeks of intravenous flucloxacillin 2 g four times daily with a 6 week follow-on course of oral clindamycin 450 mg three times daily. This case represents the first reported deep abscess forming infection with this recently discovered organism. This case highlights that (1) has a potential for invasive zoonotic infection, (2) treatment as for appears adequate for resolution of the case, (3) the increased use of the matrix-assisted laser desorption/ionisation time-of-flight identification technique is leading to more specific identification of previously unrecognised organisms.

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Human infections due to Staphylococcus pseudintermedius, an emerging zoonosis of canine origin: report of 24 cases

Cited by 175 publications

References 24 publications

Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner

Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner

Frequency and antimicrobial susceptibility of Staphylococcus pseudintermedius in dogs with otitis externa

A spinal infection withStaphylococcus pseudintermedius

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