Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

Wang, Yan; Pei, Gang; Cai, Yunxin; Zhao, Zhenlu; Wang, J B.; Jiang, Chaohui; Zheng, Zhiming; Liu, X Y.

doi:10.1097/00001756-199612200-00003

Cited by 27 publications

(18 citation statements)

References 5 publications

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“…Furthermore, this binding of IL-2 to opioid receptor induces a corresponding signal transduction. IL-2 could reduce the intracellular cyclic AMP concentrations of NG108-15 cells, with ‰-opioid receptor only, and HEK 293 cells transfected with ‰-opioid receptor [77]. These results suggest that IL-2 could directly and functionally bind to opioid receptor.…”

Section: Receptor Mechanism Of Analgesic Effect Of Il-2mentioning

confidence: 73%

Interleukin-2 and Its Effects in the Central Nervous System

Jiang

Lu²

1998

Biol Signals Recept

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Interleukin-2 (IL-2) is not only an important immunoregulatory molecule: it is also an important neuroregulatory molecule in the CNS. Investigations in vivo and in vitro have elucidated the following: IL-2 and IL-2 receptors (IL-2R) have been detected in the brain; IL-2 promotes survival and neurite extension of cultured neurons, stimulates oligodendrocyte proliferation and maturation, affects the hypothalamic-pituitary function and produces behavioral and electrocorticogram spectrum changes. Investigations in some laboratories, including ours, have also demonstrated an analgesic effect of IL-2 in the CNS. The molecular structure of the analgesic domain of IL-2 is distinct from the immune domain mediating immunoregulatory effects. A possible mechanism of action of cytokines on the CNS and the immune system or both exists: multiple actions of cytokines could be mediated by distinct domains or functional sites of cytokines interacting with different receptors or receptor subtypes.

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Section: Receptor Mechanism Of Analgesic Effect Of Il-2mentioning

confidence: 73%

Interleukin-2 and Its Effects in the Central Nervous System

Jiang

Lu²

1998

Biol Signals Recept

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“…Some evidence suggests that opioid receptors may be involved [2,3]. Our previous studies [4] showed preliminary evidence for the direct action of IL-2 on opioid receptors.…”

Section: Discussionmentioning

confidence: 86%

“…Otherwise, cytokines play unique roles as signal molecules in the bi-directional communication between the nerve system and the biodefense system. Cumulative evidence exists that several cytokines can modulate nociception [4,17]. Some evidence suggests that opioid receptors may be involved [2,3].…”

Section: Discussionmentioning

confidence: 99%

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Suppression of morphine withdrawal syndrome by interleukin-2 and its gene

Yao²,

Wang³

et al. 2005

NeuroReport

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The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied. The results showed that rIL-2 could signi¢cantly decrease the number of jumps in mice. In rats, rIL-2 signi¢cantly suppressed irritating, diarrhea, weight loss, abnormal posture and salivation.Tendencies towards reductions in teeth chewing and dog-shaking were also observed. Furthermore, pcDNA3-IL-2 (8 mg DNA) had a similar e¡ect as 1 Â 10 4 IU rIL-2 protein on inhibition of morphine withdrawal syndrome in mice, and the expression of rIL-2 protein in spinal cord could be detected for 6 days.These ¢ndings provided further evidence for the neuroregulatory function of an immunological molecule such as IL-2. NeuroReport16:387^391

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“…18 IL-2 is an important immuno-regulatory molecule in the central nervous system (CNS). 19,20 IL-2 and IL-2 receptors are widely distributed in rat CNS 21 and evidence showed that IL-2 had an antinociceptive effect in both central and peripheral nervous system 22 and inhibited nociceptive responses of spinal dorsal horn neurons. 23 Yao et al 24 reported that intrathecal delivery of an adenoviral vector expressing IL-2 produced antinociceptive effects measured by basal nociceptive response and in a model of chronic neuropathic pain induced by sciatic nerve injury.…”

Section: Adenovirus Vectormentioning

confidence: 99%