Human intestinal fatty acid binding protein in peritoneal fluid is a marker of intestinal ischemia

Sonnino, Roberta; Ereso, Glenn L.; Arcuni, Joanna; Franson, Richard C.

doi:10.1016/s0041-1345(00)01225-2

Cited by 24 publications

(17 citation statements)

References 2 publications

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“…Sonnino et al (9) reported that peritoneal fluid levels of I-FABP, a protein that is only present in the villus tips of intestinal mucosa and is not present in the circulation under normal conditions, is strongly correlated with severity of intestinal ischemia (3). It has been shown that functional and structural changes in intestinal mucosa begin with the short-term (5-15 min) disappearance of superior mesenteric artery flow, and then gradually become more severe with time.…”

Section: Discussionmentioning

confidence: 99%

“…This was done by attaching a three-way connector to the end of the transurethral catheter, injecting 25 mL of sterile saline solution into the bladder through one port, and then measuring IAP by attaching a manometer to the other available port. Intraabdominal pressure was measured with the patient in supine position and at the end of expiration, and the mid-axillary line was accepted as the zero point (9). This measurement was taken at four time points: beginning of surgery, end of surgery, 12-hour postoperatively, 24-hour postoperatively.…”

Section: Study Protocolmentioning

confidence: 99%

“…I-FABP is strongly correlated with severity of intestinal ischemia (9). However, there are no data on the IFAP levels in patients undergoing coronary artery bypass surgery (CABG).…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Camkiran¹,

Dönmez²,

Aldemir³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Çalışmamızın amacı, kardiyopulmoner baypas (KPB) uygulanan ve uygulanmayan (OPCAB) hastalarda intestinal iskemi ile intestinal yağ asidi bağlayıcı protein (I-FABP) arasında ilişki olup olmadığını belirlemektir. Yöntemler: Çalışma prospektif, gözlemsel olarak planlandı. Elektif koroner arter baypas greftleme cerrahisi uygulanacak 50-70 yaşları arasında hastalar ardışık olarak çalışmaya alındı. Kardiyopulmoner baypas uygulanan 35 hasta birinci grup (CPB), uygulanmayan 16 hasta ikinci grup (OPCAB) olarak kabul edildi. Gruplar arası ve grup içi karşılaştırmalar Student's t, Mann-Whitney U, Friedman ve Wilcoxon testleri ile analiz edildi. Bulgular: Kardiyopulmoner baypas uygulanan grubun I-FABP düzeylerinde operasyon sonunda, başlangıca göre anlamlı yükselme olurken (p<0.005), postoperatif 12. ve 24. saatlerde operasyon bitişine göre anlamlı düşme görüldü (sırasıyla p<0.001, p<0.001). Kardiyopulmoner baypas uygulanmayan grupta ise operasyon sonunda operasyon başlangıcına göre yükselme görülürken (p<0.001), postoperatif 24. saatte operasyon başlangıcına göre anlamlı düşme görüldü (p<0.001). Her iki grubun I-FABP düzeyleri cerrahi bitiminde preoperatif değerlere göre anlamlı şekilde yükseldi. Sonuç: Çalışmamız sırasında hiçbir hastamızda intestinal iskemi görülmezken, I-FABP düzeylerindeki değişiklik bize açık kalp cerrahisi geçiren hastalarda intestinal iskemi monitörizasyonunda I-FABP'nin kullanılabileceğini düşündürdü. ABSTRACTObjective: The aim of this study was to determine whether serum levels of intestinal type fatty acid binding protein (I-FABP) are related to intestinal ischemia in patients undergoing coronary bypass surgery. Methods: The study was planned as prospective, observational. Elective coronary artery bypass candidate patients between ages of 50 and 70 were consecutively included in the study. Thirty-five patients scheduled for cardiopulmonary bypass (CPB) were identified as the CPB group and 16 patients not scheduled for CPB were identified as the off-pump coronary artery bypass surgery (OPCAB) group. The variables between and within the groups were analyzed with Student's t, Mann-Whitney U, Friedman and Wilcoxon tests respectively. Results: In both CPB and OPCAB groups, I-FABP level at the end of the operation was significantly higher than that noted at the beginning of the operation (p<0.005). In the CPB group, there was a significant drop in I-FABP from the end of the operation to each of the postoperative time points (12 th hour and 24 th hour) (respectively p<0.001, p<0.001). In the OPCAB group, the I-FABP levels at both postoperative time points were lower than that at the end of the operation (p<0.001), and the level at 24-hour post-surgery was significantly lower than at both the end-of-operation I-FABP value (p<0.001) and the 12-hour post-surgery I-FABP value. Conclusion: Since we have not observed any intestinal ischemia through our research, slight changes of I-FABP measurements make us believe that I-FABP would be a valuable way to monitor for intestinal ischemia in patients w...

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Section: Discussionmentioning

confidence: 99%

Section: Study Protocolmentioning

confidence: 99%

See 1 more Smart Citation

Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Camkiran¹,

Dönmez²,

Aldemir³

et al. 2011

Anadolu Kardiyol Derg

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show abstract

“…In clinical settings, I-FABP concentrations measured in peritoneal fluid, plasma and urine are significantly higher in patients with i3 than in healthy controls and patients with other causes of the acute abdomen [66][67][68]. In peritoneal fluid, whose presence reveals late and severe disease, high levels of I-FABP were detected in patients with intestinal diseases [68].…”

Section: Fatty Acid-binding Proteins (Fabp) Biomarkers Of Villi Injurymentioning

confidence: 97%

Diagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far

Peoc’h

Nuzzo

Guedj

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Acute intestinal ischemic injury (i3) is a lifethreatening condition with disastrous prognosis, which is currently difficult to diagnose at the early stages of the disease; a rapid diagnosis is mandatory to avoid irreversible ischemia, extensive bowel resection, sepsis and death. The overlapping protein expression of liver and gut related to the complex physiopathology of the disease, the heterogeneity of the disease and its relative rarity could explain the lack of a useful early biochemical marker of i3. Apart from non-specific biological markers of thrombosis, hypoxia inflammation, and infection, several more specific biomarkers in relation with the gut barrier dysfunction, the villi injury and the enterocyte mass have been used in the diagnosis of acute i3. It includes particularly D-lactate, intestinal fatty acid-binding protein (FABP) and citrulline. Herein, we will discuss leading publications concerning these historical markers that point out the main limitations reagrding their use in routine clinical practice. We will also introduce the first and limited results arising from omic studies, underlying the remaining effort that needs to be done in the field of acute i3 biological diagnosis, which remains a challenge.

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“…[22] Sonnino et al found strong statistical correlation between intestinal ischemia and levels of fatty acid-binding proteins in peritoneal fluid normally found only in intestinal mucosa villus tips, not in the circulatory system. [23] Diagnostic use of inert Xenon (Xe 54 ) gas is promising in early diagnosis of AMIwhen dissolved in salt and injected into the peritoneal cavity, it is absorbed with passive diffusion into the intestine. While tissues with normal perfusion can clean this gas easily, ischemic tissues cannot.…”

Section: Discussionmentioning

confidence: 99%

Role Of Alkaline Phosphatase Intestine-Isomerase In Acute Mesenteric Ischemia Diagnosis

Lapsekili¹,

Menteş

Balkan

et al. 2015

Ulus Travma Acil Cerrahi Derg

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Human intestinal fatty acid binding protein in peritoneal fluid is a marker of intestinal ischemia

Cited by 24 publications

References 2 publications

Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Diagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far

Role Of Alkaline Phosphatase Intestine-Isomerase In Acute Mesenteric Ischemia Diagnosis

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