2021
DOI: 10.3390/bioengineering8120223
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Human iPSC-Derived Vascular Smooth Muscle Cells in a Fibronectin Functionalized Collagen Hydrogel Augment Endothelial Cell Morphogenesis

Abstract: Tissue-engineered constructs have immense potential as autologous grafts for wound healing. Despite the rapid advancement in fabrication technology, the major limitation is controlling angiogenesis within these constructs to form a vascular network. Here, we aimed to develop a 3D hydrogel that can regulate angiogenesis. We tested the effect of fibronectin and vascular smooth muscle cells derived from human induced pluripotent stem cells (hiPSC-VSMC) on the morphogenesis of endothelial cells. The results demons… Show more

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Cited by 12 publications
(17 citation statements)
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“…To realize their full therapeutic potential, there remains a need to optimize culture conditions to improve cell survival, and paracrine secretion 28 . We and others have used functionalized biomaterials to enhance stem cell survival, and paracrine secretion both in vitro and in vivo 16,37–39 . Spheroids with a 3D tissue‐like architecture have been shown to improve cell‐survival, paracrine secretion, and improved regenerative potential 4,6,8,14,16,21,28 …”
Section: Discussionmentioning
confidence: 99%
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“…To realize their full therapeutic potential, there remains a need to optimize culture conditions to improve cell survival, and paracrine secretion 28 . We and others have used functionalized biomaterials to enhance stem cell survival, and paracrine secretion both in vitro and in vivo 16,37–39 . Spheroids with a 3D tissue‐like architecture have been shown to improve cell‐survival, paracrine secretion, and improved regenerative potential 4,6,8,14,16,21,28 …”
Section: Discussionmentioning
confidence: 99%
“…A pure population of hiPSC‐VSMC was generated using a previously established protocol 1,37–39 . In brief, hiPSCs were cultured in feeder‐free conditions until reaching 80% confluency.…”
Section: Methodsmentioning
confidence: 99%
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