Human Leptospira interrogans serogroup icterohaemorrhagiae infection (Weil's disease) acquired from pet rats

Gaudie, C.; Featherstone, C. A.; Phillips, W. S.; McNaught, R.; Rhodes, P. M.; Errington, Jane; Fearnley, Catherine; Fenner, Jackie; Pritchard, G. C.

doi:10.1136/vr.163.20.599

Cited by 23 publications

(17 citation statements)

References 10 publications

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“…The carcases were submitted to VLA — Thirsk for postmortem examination, and pathogenic leptospiral DNA was subsequently detected by real-time PCR (Fearnley and others 2008) from the kidney of rat C, while tissue from rat B was negative. This technique is not specific for L icterohaemorrhagiae but, as with the incident described by Gaudie and others (2008), denaturing high-performance liquid chromatography subsequently showed it to be a member of the interrogans group, and one of five strains including icterohaemorrhagiae.…”

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confidence: 68%

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Weil's disease associated with the adoption of a feral rat

Strugnell¹,

Featherstone²,

Gent

et al. 2009

Veterinary Record

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confidence: 68%

“…The incident was investigated collaboratively by the West Yorkshire Health Protection Unit (WYHPU), the Veterinary Laboratories Agency (VLA)—Thirsk, and the Department of Infection and Travel Medicine, St James's University Hospital, Leeds. It follows the publication by Gaudie and others (2008) of a similar case of Weil's disease acquired from a pet rat.…”

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confidence: 99%

Weil's disease associated with the adoption of a feral rat

Strugnell¹,

Featherstone²,

Gent

et al. 2009

Veterinary Record

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“…Rats are important as carriers and transmitters of a number of pathogens to humans and livestock as well as pet animals thereby posing public health hazards to humans [5, 16, 35, 36]. It was therefore of epidemiological relevance that the rats trapped in the current study which were from as many as 44 locations across the island of Trinidad were positive for E. coli , Salmonella spp., and Campylobacter spp.…”

Section: Discussionmentioning

confidence: 96%

Frequency of Detection ofEscherichia coli,Salmonellaspp., andCampylobacterspp. in the Faeces of Wild Rats (Rattusspp.) in Trinidad and Tobago

Nkogwe

Raletobana

Stewart-Johnson

et al. 2011

Veterinary Medicine International

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The study was conducted to determine the frequency of isolation of Salmonella, Campylobacter and E. coli O157 in the faecal samples of rats trapped across the regional corporations in Trinidad and to assess their resistance to antimicrobial agents. A total of 204 rats were trapped for the detection of selected bacteria. Standard methods were used to isolate Salmonella, Campylobacter and E. coli O157. Characterization of E. coli was done on sorbitol MacConkey agar to determine non-sorbitol fermentation, blood agar to determine haemolytic and mucoid colonies and by using E. coli O157 antiserum to determine O157 strain. The disc diffusion method was used to determine resistance to nine antimicrobial agents. Of the 204 rats, 4 (2.0%), 7 (3.4%) and 171 (83.8%) were positive for Salmonella spp., Campylobacter spp. and E. coli, respectively. Of the 171 isolates of E. coli tested 0 (0.0%), 25 (14.6%) and 19 (11.1%) were haemolytic, mucoid and non-sorbitol fermenters, respectively. All isolates were negative for the O157 strain. The frequency of resistance to the 9 antimicrobial agents tested was 75% (3 of 4) for Salmonella, 85.7% (6 of 7) of Campylobacter spp. and 36.3% (62 of 171) for E. coli (P < .05; χ2).

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“…Animals of different species, including rodents, act as maintenance hosts for different serovars of Leptospira (38). Several studies show that wild rodents are common carriers of leptospires, including feral rodents (39), rodents on farms (40), and rodent pets (41). A high proportion of sewer rats in Copenhagen were recently found to be infected with serovars Pomona, Sejroe, and Icterhaemorrhagiae (42).…”

Section: Rodents As Carriers Of Zoonotic Diseasementioning

confidence: 99%

Rodents on pig and chicken farms – a potential threat to human and animal health

Backhans

Fellström

2012

Infection Ecology & Epidemiology

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Rodents can cause major problems through spreading various diseases to animals and humans. The two main species of rodents most commonly found on farms around the world are the house mouse (Mus musculus) and the brown rat (Rattus norvegicus). Both species are omnivorous and can breed year-round under favourable conditions. This review describes the occurrence of pathogens in rodents on specialist pig and chicken farms, which are usually closed units with a high level of bio-security. However, wild rodents may be difficult to exclude completely, even from these sites, and can pose a risk of introducing and spreading pathogens. This article reviews current knowledge regarding rodents as a hazard for spreading disease on farms. Most literature available regards zoonotic pathogens, while the literature regarding pathogens that cause disease in farm animals is more limited.

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Human Leptospira interrogans serogroup icterohaemorrhagiae infection (Weil's disease) acquired from pet rats

Cited by 23 publications

References 10 publications

Weil's disease associated with the adoption of a feral rat

Weil's disease associated with the adoption of a feral rat

Frequency of Detection ofEscherichia coli,Salmonellaspp., andCampylobacterspp. in the Faeces of Wild Rats (Rattusspp.) in Trinidad and Tobago

Rodents on pig and chicken farms – a potential threat to human and animal health

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