Human Leucocyte Antigen alleles associated with asparaginase hypersensitivity in childhood Acute Lymphoblastic Leukemia patients treated with Pegylated asparaginase within Dana Farber Cancer Institute treatment protocols

Kondyli, Maria; Tremblay, David-Étienne; Rezgui, Aziz; Serfaty, Sophie Annaelle; Gagné, Vincent; Ribère, Maïté; Laverdière, Caroline; Leclerc, Jean‐Marie; Tran, Thai Hoa; Sinnett, Daniel; Krajinović, Maja

doi:10.1016/j.leukres.2021.106650

Leukemia Research

2021

DOI: 10.1016/j.leukres.2021.106650

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Human Leucocyte Antigen alleles associated with asparaginase hypersensitivity in childhood Acute Lymphoblastic Leukemia patients treated with Pegylated asparaginase within Dana Farber Cancer Institute treatment protocols

Maria Kondyli

David-Étienne Tremblay

Aziz Rezgui

et al.

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2024

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Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences

Cecconello,

Silva,

de Senna

et al. 2024

Pharmaceutics

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Acute lymphoblastic leukemia represents the most prevalent childhood cancer. Modern chemotherapy has significantly improved outcomes, achieving EFS rates of 80% and OS rates nearing 90% in developed nations, while in developing regions, rates remain below 50%, highlighting disparities, and this difference is due to several factors. Genetic variability plays a role in these drug response disparities, presenting single-nucleotide variations (SNVs). Pharmacogenetic research aims to pinpoint these SNVs early in treatment to predict specific drug responses effectively. This review aims to explore advancements in pharmacogenetics associated with asparaginase (ASNase). ASNase plays a crucial role in the treatment of ALL and is available in three formulations: E. coli, Erwinia, and PEG ASNase. ASNase therapy presents challenges due to adverse effects, like hypersensitivity reactions. Identifying predictive markers for hypersensitivity development beforehand is crucial for optimizing treatments. Several pharmacogenetic studies have investigated the association between SNVs and the risk of hypersensitivity. Key genes include GRIA1, NFATC2, CNTO3, ARHGAP28, MYBBP1A, and HLA. Studies have highlighted associations between SNVs within these genes and hypersensitivity reactions. Notably, most pharmacogenetic investigations of hypersensitivity have focused on patients treated with E. coli, emphasizing the need for broader exploration across different formulations. Future research investigating these variants holds promise for advancing our understanding of ASNase’s pharmacogenetics.

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Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences

Cecconello,

Silva,

de Senna

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

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Human Leucocyte Antigen alleles associated with asparaginase hypersensitivity in childhood Acute Lymphoblastic Leukemia patients treated with Pegylated asparaginase within Dana Farber Cancer Institute treatment protocols

Cited by 1 publication

References 14 publications

Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences

Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences

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