Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss

Dahl, Mette; Hviid, Thomas Vauvert F.

doi:10.1093/humupd/dmr043

Cited by 78 publications

(62 citation statements)

References 155 publications

(161 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9). Interestingly, it has been found recently that reduced or aberrant HLA-G expression seemed to be associated with certain complications of pregnancy, including the risk of miscarriage or preeclampsia (53)(54)(55)(56)(57)(58)(59). However, when soluble HLA-G isoforms were analyzed late in pregnancy, a low level of sHLA-G5 seemed to be associated with uncomplicated pregnancy, whereas in preeclampsia, the levels of sHLA-G5 were higher (60,61).…”

Section: Discussionmentioning

confidence: 99%

HLA-G5 Induces IL-4 Secretion Critical for Successful Pregnancy through Differential Expression of ILT2 Receptor on Decidual CD4+ T Cells and Macrophages

Lombardelli

Aguerre-Girr

Logiodice

et al. 2013

The Journal of Immunology

View full text Add to dashboard Cite

Successful pregnancy in humans has been associated with production of IL-4 by T cells at the feto–maternal interface. Soluble HLA-G5 produced by trophoblasts potentially controls the decidual T cell cytokine profile. We studied the effect of HLA-G5 on the cytokine profile of purified human macrophages and Ag-specific T cells in vitro. We demonstrated that HLA-G5 increased production of IL-12 by purified peripheral blood macrophages. Although IL-12 production by macrophages is known to induce IFN-γ production by CD4+ T cells, HLA-G5 increased production of IL-4 but not IFN-γ by CD4+ T cells after Ag presentation by macrophages. We found that this apparent paradox was due to the differential expression of the ILT2 HLA-G5 receptor on activated T cells and macrophages. This receptor was upregulated in the former and downregulated in the latter after Ag presentation and activation of both cell types. This observation was confirmed in situ, where decidual macrophages and T cells are continuously exposed to HLA-G5 produced locally and activated by trophoblast alloantigens. Freshly isolated decidua basalis macrophages expressed lower levels of ILT2 than peripheral blood macrophages from the same pregnant women. They did not spontaneously produce IL-12, whereas freshly isolated decidual CD4+ T cells expressed high levels of activation markers (CD25, HLA-DR, and CD69) as well as ILT2 and spontaneously produced IL-4 but not IFN-γ. Therefore, HLA-G5 could be responsible, at least in part, via its interaction with ILT2, for decidual T cell IL-4 production, known to be crucial for successful pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

HLA-G5 Induces IL-4 Secretion Critical for Successful Pregnancy through Differential Expression of ILT2 Receptor on Decidual CD4+ T Cells and Macrophages

Lombardelli

Aguerre-Girr

Logiodice

et al. 2013

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Furthermore McCormick et al, (2009) reported that sHLA-G actually inhibit trophoblast invasion of the maternal deciduas [13]. Dahl and colleagues in 2014 also reported that HLA-G may inhibit trophoblast invasion in concentrationdependent manners [14]. It could be that sHLA-G may not play a role in implantation, but rather in the maintenance of maternal immune tolerance to fetal antigen after implantation, because plasma sHLA-G levels increased with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion in this study.…”

Section: Discussionmentioning

confidence: 99%

Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital

Mubarak¹,

Blebu²,

Mumuni³

et al. 2016

OJI

View full text Add to dashboard Cite

Introduction: Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at immune privileged sites and its ability to inhibit the effectors functions of immune cells has set HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy. Methods: Soluble HLA-G (sHLA-G) levels were measured using a BioVendor sHLA-G ELISA kit following the manufacturer's protocol. The study participants include women undergoing spontaneous abortion, non-pregnant women, males and an archive sample of women who had normal vaginal deliveries without any complications and any history of malaria infection from gestation to delivery. Results: Soluble HLA-G levels were higher among women undergoing spontaneous abortion as compared to women who had normal vaginal delivery and non-pregnant women. Soluble HLA-G levels were also higher in second trimester as compared to first trimester in both women who had spontaneous abortions and women who had normal delivery. Conclusion: Although sHLA-G levels were higher among women undergoing spontaneous abortion as compared to non-pregnant women and women who had normal delivery, this may be playing a role in the maintenance of maternal immune tolerance to fetal antigen, since plasma sHLA-G levels increased with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion.

show abstract

“…This results in the translation of four so-called membrane-bound isoforms (full length HLA-G1, and HLA-G2, -G3, and -G4 smaller forms), as well as three soluble isoforms (HLA-G5, -G6, and -G7). [13][14][15][16] Due to a stop codon in intron 4, these latter forms have neither transmembrane nor cytoplasmic translated domains. As a result, these secreted isoforms exhibit a small tail corresponding to the translated part of intron 4.…”

Section: Hla-g Is Expressed By Fetal-derived Trophoblastmentioning

confidence: 99%

“…[3][4][5][6][7][8] The reader may also refer to previous excellent reviews on the subject. [9][10][11][12][13] …”

mentioning

confidence: 99%

HLA-G in human early pregnancy: Control of uterine immune cell activation and likely vascular remodeling

Bouteiller¹

2015

Biomed J

View full text Add to dashboard Cite

Despite a number of controversies, the functional importance of human leukocyte antigen G (HLA-G) in early human pregnancy is now sustained by a large amount of sound data. Membrane-bound and soluble HLA-G isoforms, either as b2-microglobulin-free or -associated as monomers or dimers, are expressed by different trophoblast subpopulations, the only fetal-derived cells that are directly in contact with maternal cells (maternal-

show abstract

Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss

Cited by 78 publications

References 155 publications

HLA-G5 Induces IL-4 Secretion Critical for Successful Pregnancy through Differential Expression of ILT2 Receptor on Decidual CD4+ T Cells and Macrophages

HLA-G5 Induces IL-4 Secretion Critical for Successful Pregnancy through Differential Expression of ILT2 Receptor on Decidual CD4+ T Cells and Macrophages

Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital

HLA-G in human early pregnancy: Control of uterine immune cell activation and likely vascular remodeling

Contact Info

Product

Resources

About